Results 21 to 30 of about 12,977 (200)

Proteomic Analysis of Regulated Dendritic Cell Endosomes Reveals Dynamic Adaptation to Antigen Uptake and Cross-Presentation. [PDF]

Eur J Immunol
Phagocytosis of yeast activates recruitment of proteases and trafficking factors from the secretory and endosomal pathways to the IRAP compartment and subsequently phagosomes, promoting cross‐presentation. In the absence of Sec22b, IRAP endosome and phagosome maturation to late endosomes is accelerated.
Senni A, Grumbach L, Ceccacci S, Frechin M, Goudin N, Guerrera IC, Bertocci B, van Endert P.   +7 more
europepmc   +2 more sources

The ECJ’s Remarkable Decision on IRAP

, 2007
The prejudicial question: IRAP as tax with the characteristics of “turnover tax ” in breach of Article 33 of the Sixth Directive. General criticisms concerning the theory of incompatibility of IRAP with the Sixth Directive. Error in perspective: the need for a iure communitatis assessment.
CONTRINO, Angelo
openaire   +3 more sources

Comparing delayed matching to sample with three variations of the training-IRAP for establishing derived relations. [PDF]

J Exp Anal Behav
Abstract A common method for studying derived relations is the matching‐to‐sample (MTS) preparation. However, certain aspects of its training format potentially hinder the emergence of new relations. The training version of the implicit relational assessment procedure (training‐IRAP) may present an alternative.
Silvestre MH, Harte C, Passarelli DA, de Rose JC.   +3 more
europepmc   +2 more sources

Benzylhydroxamic acids as inhibitors of insulin regulated aminopeptidase (IRAP)

European Journal of Medicinal Chemistry Reports
With the objective of finding new classes of cognitive enhancers with potential for the treatment of neurodegenerative disorders, such as Alzheimer's disease, small molecule inhibitors of insulin-regulated aminopeptidase (IRAP) were designed and ...
Julia Beveridge, Marcus Söderström, Rubén Prieto-Díaz, Hugo Gutierrez-de-Teran, Luke R. Odell, Mathias Hallberg, Mats Larhed, Johan Gising   +7 more
doaj   +2 more sources

Discovery of Selective Inhibitor Leads by Targeting an Allosteric Site in Insulin-Regulated Aminopeptidase

Pharmaceuticals, 2021
Insulin-Regulated aminopeptidase (IRAP) is a zinc-dependent aminopeptidase with several important biological functions and is an emerging pharmaceutical target for cognitive enhancement and immune system regulation.
Ioannis Temponeras, Lykourgos Chiniadis, Athanasios Papakyriakou, Efstratios Stratikos   +3 more
doaj   +1 more source

Insulin-regulated aminopeptidase contributes to setting the intensity of FcR-mediated inflammation

Frontiers in Immunology, 2022
The function of intracellular trafficking in immune-complex triggered inflammation remains poorly understood. Here, we investigated the role of Insulin-Regulated Amino Peptidase (IRAP)-positive endosomal compartments in Fc receptor (FcR)-induced ...
Manuela Bratti, Manuela Bratti, Shamila Vibhushan, Shamila Vibhushan, Cyril Longé, Despoina Koumantou, Despoina Koumantou, Gaël Ménasché, Marc Benhamou, Marc Benhamou, Nadine Varin-Blank, Ulrich Blank, Ulrich Blank, Loredana Saveanu, Loredana Saveanu, Sanae Ben Mkaddem, Sanae Ben Mkaddem   +16 more
doaj   +1 more source

Reciprocal Expression Patterns of Placental Leucine Aminopeptidase/Insulin-Regulated Aminopeptidase and Vasopressin in the Murine Brain

Frontiers in Molecular Biosciences, 2020
Placental leucine aminopeptidase/insulin-regulated aminopeptidase (P-LAP/IRAP) regulates vasopressin and oxytocin levels in the brain and peripheral tissues by controlled degradation of these peptides.
Yoshikuni Goto, Takahiro J. Nakamura, Kenji Ogawa, Akira Hattori, Masafumi Tsujimoto   +4 more
doaj   +1 more source

Inhibition of insulin-regulated aminopeptidase confers neuroprotection in a conscious model of ischemic stroke

Scientific Reports, 2023
Stroke is a leading cause of mortality and morbidity with a paucity of effective pharmacological treatments. We have previously identified insulin-regulated aminopeptidase (IRAP) as a potential target for the development of a new class of drugs for the ...
Jonathon Telianidis, Andrew Hunter, Robert Widdop, Barbara Kemp-Harper, Vi Pham, Claudia McCarthy, Siew Yeen Chai   +6 more
doaj   +1 more source

Improvement Of Road Safety Conditions Based on IRAP Star Rating and Road Safety Inspection (Case Study Kopo – Soreang Provincial Road)

Jurnal Teknik Sipil, 2023
The iRAP Star Rating Methodology and Road Safety Inspection (RSI) have similar objectives to improve road safey condition but with different approaches.
Dhuha Ahdika Husnudzon, Aine Kusumawati, Widyarini Weningtyas   +2 more
doaj   +1 more source

The Role of Insulin Regulated Aminopeptidase in Endocytic Trafficking and Receptor Signaling in Immune Cells

Frontiers in Molecular Biosciences, 2020
Insulin regulated aminopeptidase (IRAP) is a type II transmembrane protein with broad tissue distribution initially identified as a major component of Glut4 storage vesicles (GSV) in adipocytes.
Delphyne Descamps, Irini Evnouchidou, Irini Evnouchidou, Vivien Caillens, Carole Drajac, Sabine Riffault, Peter van Endert, Peter van Endert, Peter van Endert, Loredana Saveanu   +9 more
doaj   +1 more source