Results 51 to 60 of about 3,708 (156)

Stabilization of the open conformation οf insulin-regulated aminopeptidase by a novel substrate-selective small-molecule inhibitor. [PDF]

Protein Sci
Insulin-regulated aminopeptidase (IRAP) is an enzyme with important biological functions and the target of drug-discovery efforts. We combined in silico screening with a medicinal chemistry optimization campaign to discover a nanomolar inhibitor of IRAP ...
Mpakali A, Georgaki G, Buson A, Findlay AD, Foot JS, Mauvais FX, van Endert P, Giastas P, Hamprecht DW, Stratikos E.   +9 more
europepmc   +2 more sources

Insulin-regulated aminopeptidase in adipocyte is Cys-specific and affected by obesity [PDF]

Journal of Molecular Endocrinology, 2015
Insulin-regulated aminopeptidase (IRAP, EC 3.4.11.3) in adipocytes is well known to traffic between high (HDM) and low (LDM) density microsomal fractions toward the plasma membrane (MF) under stimulation by insulin. However, its catalytic preference for aminoacyl substrates with N-terminal Leu or Cys is controversial.
Rafaela Fadoni, Alponti, Luciana Godoy, Viana, Norma, Yamanouye, Paulo Flavio, Silveira   +3 more
openaire   +2 more sources

Proteomic Analysis of Regulated Dendritic Cell Endosomes Reveals Dynamic Adaptation to Antigen Uptake and Cross-Presentation. [PDF]

Eur J Immunol
Phagocytosis of yeast activates recruitment of proteases and trafficking factors from the secretory and endosomal pathways to the IRAP compartment and subsequently phagosomes, promoting cross‐presentation. In the absence of Sec22b, IRAP endosome and phagosome maturation to late endosomes is accelerated.
Senni A, Grumbach L, Ceccacci S, Frechin M, Goudin N, Guerrera IC, Bertocci B, van Endert P.   +7 more
europepmc   +2 more sources

Intrathecal injections of non-peptide oxytocin receptor agonists, WAY 267,464 and TC OT 39, induce significant anti-hyperalgesia in both male and female rats with inflammatory pain [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Hyperalgesia is a clinical condition related to chronic pain in which patients experience increased nociceptive sensitivity. Intrathecal oxytocin has been shown to induce significant anti-hyperalgesia in both rodents and humans. However, in
Lok-Hi Chow, Yuan-Hao Chen, Ying-Jie Chen, Pin-Chen Lin, Eagle Yi-Kung Huang   +4 more
doaj   +1 more source

Insulin and glucose play a role in foam cell formation and function

Cardiovascular Diabetology, 2006
Background Foam cell formation in diabetic patients often occurs in the presence of high insulin and glucose levels. To test whether hyperinsulinemic hyperglycemic conditions affect foam cell differentiation, we examined gene expression, cytokine ...
Keller Susanna R, Huo Yuqing, Rissing Benjamin A, Miller Yury I, Jain Nitin, Shashkin Pavel N, Vandenhoff George E, Nadler Jerry L, McIntyre Thomas M   +8 more
doaj   +1 more source

Anti-Inflammatory and Antitumor Effects of Hydroxytyrosol but Not Oleuropein on Experimental Glioma In Vivo. A Putative Role for the Renin-Angiotensin System

Biomedicines, 2018
Functional roles of the angiotensin peptides of the renin-angiotensin system (RAS) cascade can be analyzed through their corresponding proteolytic regulatory enzymes aspartyl aminopeptidase (ASAP), aminopeptidase A (APA), aminopeptidase B (APB ...
María Jesús Ramírez-Expósito, José Manuel Martínez-Martos   +1 more
doaj   +1 more source

Crystal structure of insulin-regulated aminopeptidase with bound substrate analogue provides insight on antigenic epitope precursor recognition and processing

, 2015
Aminopeptidases that generate antigenic peptides influence immunodominance and adaptive cytotoxic immune responses. The mechanisms that allow these enzymes to efficiently process a vast number of different long peptide substrates are poorly understood ...
Papakyriakou, Athanasios, Stratikos, Efstratios, Harlos, Karl, Zhao, Yuguang, Georgiadis, Dimitris, Mpakali, Anastasia, Saridakis, Emmanuel, Kokkala, Paraskevi   +7 more
core   +1 more source

The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation

Frontiers in Immunology, 2022
The Endoplasmic Reticulum Aminopeptidase 1 and 2 (ERAP1 and ERAP2) and Insulin Regulated Aminopeptidase (IRAP) are three M1 zinc metalloproteases whose role in antigen processing is the refining of peptidome either in the Endoplasmic reticulum (ERAP1 and
Benedetta Mattorre, Valentina Tedeschi, Giorgia Paldino, Maria Teresa Fiorillo, Fabiana Paladini, Rosa Sorrentino   +5 more
doaj   +1 more source

Serum IRAP, a Novel Direct Biomarker of Prediabetes and Type 2 Diabetes?

Frontiers in Molecular Biosciences, 2021
Insulin resistance (IR), currently called prediabetes (PD), affects more than half of the adult population worldwide. Type 2 diabetes (T2D), which often follows in the absence of treatment, affects more than 475 million people and represents 10–20% of ...
Candice Trocmé, Nicolas Gonnet, Margaux Di Tommaso, Hanen Samouda, Jean-Luc Cracowski, Jean-Luc Cracowski, Jean-Luc Cracowski, Claire Cracowski, Stéphanie Lambert-Porcheron, Stéphanie Lambert-Porcheron, Martine Laville, Martine Laville, Martine Laville, Estelle Nobécourt, Chiraz Gaddhab, Allan Le Lay, Torsten Bohn, Christine Poitou, Christine Poitou, Karine Clément, Karine Clément, Fahd Al-Mulla, Milad S. Bitar, Milad S. Bitar, Serge P. Bottari, Serge P. Bottari, Serge P. Bottari, Serge P. Bottari   +27 more
doaj   +1 more source

From biology to biotechnology: Host‐regulation factors from parasitoid wasps are a source of bioactive molecules with translational potential

Insect Molecular Biology, EarlyView.
Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto, Andrew A. Walker, Glenn F. King   +2 more
wiley   +1 more source