Results 71 to 80 of about 3,708 (156)

Angiotensin IV displays only low affinity for native insulin-regulated aminopeptidase (IRAP).

, 2012
<p>Radioligand binding studies revealed that Ang IV binds to insulin-regulated aminopeptidase (IRAP)/&#39;AT(4) receptors&#39; with high affinity.
E. Szemenyei, D. Tourwé, G. Vauquelin, J.P. De Backer, A. Lukaszuk, G. Tóth, H. Demaegdt   +6 more
core   +1 more source

Peri‐Microvascular Glycogen and Lactate Regulate Capillary Constrictions and Ischemia Outcome in Mice

Journal of Neurochemistry, Volume 170, Issue 4, April 2026.
Disruption of astrocytic glycogen metabolism, induced by glycogen phosphorylase inhibition (DAB) or genetic deficiency of GYS1 (GYS1Nestin‐KO and GYS1Gfap‐KO), reduces lactate availability to pericytes and impairs microvascular function. This metabolic deficit leads to pericyte‐associated capillary constriction, reduced cerebral blood flow, and ...
Gokhan Uruk, Buket Donmez‐Demir, Sinem Yilmaz‐Ozcan, Canan Cakir‐Aktas, Aslihan Taskiran‐Sag, Gokce Gurler, Jordi Duran, Joan J. Guinovart, Otto Baba, Tsuyoshi Morita, Hulya Karatas, Turgay Dalkara, Muge Yemisci   +12 more
wiley   +1 more source

On‐Demand Chemically Degradable Hydrogels for Biological Applications

ChemBioChem, Volume 27, Issue 6, 27 March 2026.
This review explores the mechanisms and kinetics of chemically induced on‐demand degradation in hydrogels designed for painless dressing removal and traceless dissolution across various biological applications. Covalent bond cleavage and noncovalent disruption triggers are compared, highlighting opportunities for load‐bearing scaffolds with faster ...
Xinyi Sheng, Justin Kim
wiley   +1 more source

The clinical course and pathophysiological investigation of adolescent gestational diabetes insipidus: a case report

BMC Endocrine Disorders, 2018
Background Gestational diabetes insipidus (GDI) is a rare endocrine complication during pregnancy that is associated with vasopressinase overproduction from the placenta.
Tatsuya Kondo, Miwa Nakamura, Sayaka Kitano, Junji Kawashima, Takeshi Matsumura, Takashi Ohba, Munekage Yamaguchi, Hidetaka Katabuchi, Eiichi Araki   +8 more
doaj   +1 more source

Sex Difference in Oxytocin-Induced Anti-Hyperalgesia at the Spinal Level in Rats with Intraplantar Carrageenan-Induced Inflammation. [PDF]

PLoS ONE, 2016
Previously, we demonstrated intrathecal administration of oxytocin strongly induced anti-hyperalgesia in male rats. By using an oxytocin-receptor antagonist (atosiban), the descending oxytocinergic pathway was found to regulate inflammatory hyperalgesia ...
Lok-Hi Chow, Yuan-Hao Chen, Wan-Chuan Wu, En-Pei Chang, Eagle Yi-Kung Huang   +4 more
doaj   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, Volume 15, Issue 10, 13 March 2026.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Development of a sandwich ELISA to detect circulating, soluble IRAP as a potential disease biomarker

Scientific Reports, 2023
There is growing interest in the use of the enzyme, insulin regulated aminopeptidase (IRAP), as a biomarker for conditions such as cardio-metabolic diseases and ischemic stroke, with upregulation in its tissue expression in these conditions.
Anika Vear, Claudia Thalmann, Kristina Youngs, Natalie Hannan, Tracey Gaspari, Siew Yeen Chai   +5 more
doaj   +1 more source

Evidence That the Angiotensin IV (AT4) Receptor Is the Enzyme Insulin-regulated Aminopeptidase [PDF]

Journal of Biological Chemistry, 2001
Central infusion of angiotensin IV or its more stable analogues facilitates memory retention and retrieval in normal animals and reverses amnesia induced by scopolamine or by bilateral perforant pathway lesions. These peptides bind with high affinity and specificity to a novel binding site designated the angiotensin AT(4) receptor. Until now, the AT(4)
A L, Albiston, S G, McDowall, D, Matsacos, P, Sim, E, Clune, T, Mustafa, J, Lee, F A, Mendelsohn, R J, Simpson, L M, Connolly, S Y, Chai   +10 more
openaire   +2 more sources

Non‐cognate CD8 Binding to MHC I Promotes Positive Selection of an MHC‐E Restricted CD8 T Cell Population

European Journal of Immunology, Volume 56, Issue 3, March 2026.
Mouse Qa1b‐restricted T cells show promiscuous requirements for positive selection. Using in vivo tetramer enrichment, in vitro APC engineering, and in vitro thymocyte stimulation, we demonstrate that a Qa1b‐restricted T cell population can be selected by both Qa1b and H2‐T11, and depends on non‐cognate CD8‐MHC I binding.
Xiaokun Yang, Melissa A. Colden, Rachel Coombs, Kathya Arana, Dan Tran, Michael Manoharan Valerio, Ellen A. Robey, Laurent Coscoy   +7 more
wiley   +1 more source

Ligand-induced conformational change of Insulin-regulated aminopeptidase: insights on catalytic mechanism and active site plasticity

, 2017
Insulin-regulated aminopeptidase (IRAP) is an enzyme with several important biological functions that is known to process a large variety of different peptidic substrates although the mechanism behind this wide specificity is not clearly understood.
Giastas, P, Kokkala, P, Georgiadis, Dimitris, Anastasia Mpakali, Georgiadis, D, Karl Harlos, Zhao, Y, Mpakali, A, Giastas, Petros, Paraskevi Kokkala, Harlos, Karl, Yuguang Zhao, Dimitris Georgiadis, Emmanuel Saridakis, Kokkala, Paraskevi, Athanasios Papakyriakou, Petros Giastas, Papakyriakou, Athanasios, Stratikos, Efstratios, Papakyriakou, A, Harlos, K, Saridakis, E, Efstratios Stratikos, Zhao, Yuguang, Mpakali, Anastasia, Saridakis, Emmanuel, Stratikos, E   +26 more
core   +2 more sources