Results 91 to 100 of about 3,708 (156)

Early Nutritional Programing: Unlocking the Potential of Fish for Sustainable Aquaculture

Aquaculture Nutrition, Volume 2026, Issue 1, 2026.
Nutritional programing, which explores the link between early nutritional conditions and their long‐term effects on animals, is a developing field within fish biology. Suboptimal nutritional status during early life is strongly associated with a higher risk of metabolic consequences later in life, including permanent growth retardation, impaired neural
Shivendra Kumar, Aditi Banik, Maneesh Kumar Dubey, Prem Prakash Srivastava, Zsuzsanna J. Sandor, Jianguang Qin   +5 more
wiley   +1 more source

Sites of glucose transporter-4 vesicle fusion with the plasma membrane correlate spatially with microtubules.

PLoS ONE, 2012
In adipocytes, vesicles containing glucose transporter-4 (GLUT4) redistribute from intracellular stores to the cell periphery in response to insulin stimulation.
Jennine M Dawicki-McKenna, Yale E Goldman, E Michael Ostap   +2 more
doaj   +1 more source

Is There an Interplay Between the Functional Domains of IRAP?

Frontiers in Cell and Developmental Biology, 2020
As a member of the M1 family of aminopeptidases, insulin regulated aminopeptidase (IRAP) is characterized by distinct binding motifs at the active site in the C-terminal domain that mediate the catalysis of peptide substrates.
Anika Vear, Tracey Gaspari, Philip Thompson, Siew Yeen Chai   +3 more
doaj   +1 more source

[H-3]IVDE77, a novel radioligand with high affinity and selectivity for the insulin-regulated aminopeptidase

, 2013
The hexapeptide angiotensin IV (Ang IV) induces diverse biological effects such as memory enhancement and protection against ischemic stroke. Studies on the mechanism of Ang IV however are hampered by its instability and its lack of selectivity. The high-
Tourwé, Dirk, Vanderheyden, Patrick M. L., Van Den Eynde, Isabelle, Tóth, Géza, Vauquelin, Georges, Nikolaou, Alexandros, Mallareddy, Jayapal Reddy   +6 more
core   +1 more source

Grape Exosome–Like Nanovesicles Reverse the Prediabetic State in Mice

Journal of Diabetes Research, Volume 2026, Issue 1, 2026.
Objective This research explored the effect of grape exosome–like nanovesicles (GELNs) on reversing prediabetic conditions in mice and investigated the underlying mechanisms via metabolomic and gut microbiota analyses. Methods Twenty‐four C57BL/6J mice were divided into four groups: normal control, prediabetic model, GELN intervention, and nutrient ...
Zao-Ling Liu, Shu-Ya Cai, Aerna Qiayimaerdan, Zulipia Zunon, Ya-Le Yu, Xiao-Die Ma, Hannah Wesley   +6 more
wiley   +1 more source

Angiotensin II type 1 receptor blocker losartan prevents and rescues cerebrovascular, neuropathological and cognitive deficits in an Alzheimer’s disease model

Neurobiology of Disease, 2014
Angiotensin II (AngII) receptor blockers that bind selectively AngII type 1 (AT1) receptors may protect from Alzheimer’s disease (AD). We studied the ability of the AT1 receptor antagonist losartan to cure or prevent AD hallmarks in aged (~18 months at ...
Brice Ongali, Nektaria Nicolakakis, Xin-Kang Tong, Tahar Aboulkassim, Panayiota Papadopoulos, Pedro Rosa-Neto, Clotilde Lecrux, Hans Imboden, Edith Hamel   +8 more
doaj   +1 more source

The effect of insulin resistance on amygdale glucose metabolism alterations in experimental Alzheimer’s disease

Бюллетень сибирской медицины, 2018
Purpose. Glucose metabolism is tightly regulated in the brain. Aberrant glucose metabolism is an important feature of neurodegenerative diseases, as inAlzheimer’s disease.
Ya. V. Gorina, Yu. K. Komleva, O. L. Lopatina, A. I. Chernykh, A. B. Salmina   +4 more
doaj   +1 more source

Discovery of Selective Nanomolar Inhibitors for Insulin-Regulated Aminopeptidase Based on α-Hydroxy-β-amino Acid Derivatives of Bestatin

, 2023
The oxytocinase subfamily of M1 zinc aminopeptidases comprises emerging drug targets, including the ER-resident aminopeptidases 1 and 2 (ERAP1 and ERAP2) and insulin-regulated aminopeptidase (IRAP); however, reports on clinically relevant inhibitors are ...
Papakyriakou, Athanasios, Stratikos, Efstratios, Giastas, Petros, van Endert, Peter, Koumantou, Despoina, Magrioti, Victoria, Athanasoulis, Alexandros, Mpakali, Anastasia, Mavridis, Ioannis, Vourloumis, Dionisios, Leib, Jacqueline, Temponeras, Ioannis   +11 more
core   +1 more source

Trafficking Kinetics of the Insulin-Regulated Membrane Aminopeptidase in 3T3-L1 Adipocytes

Biochemical and Biophysical Research Communications, 1997
In fat and muscle cells insulin causes the marked translocation of the glucose transporter GLUT4 from its intracellular location to the plasma membrane. We and others have discovered an insulin-regulated membrane aminopeptidase (designated IRAP) that colocalizes with intracellular GLUT4 and also translocates markedly in response to insulin.
S A, Ross, J J, Herbst, S R, Keller, G E, Lienhard   +3 more
openaire   +2 more sources

Potent Macrocyclic Inhibitors of Insulin-Regulated Aminopeptidase (IRAP) by Olefin Ring-Closing Metathesis

, 2011
Macrocyclic analogues of angiotensin IV (Ang IV, Val1-Tyr2-Ile3-His4-Pro5-Phe6) targeting the insulin-regulated aminopeptidase (IRAP) have been designed, synthesized, and evaluated biologically.
Karlén, Anders,, Lindeberg, Gunnar,, Anders Hallberg, Hallberg, Mathias,, Heidi Demaegdt, Erdélyi, Máté,, Anders Johnsson, Georges Vauquelin, Hallberg, Anders,, Gunnar Lindeberg, Johnsson, Anders,, Andersson, Hanna,, Hanna Andersson, Vauquelin, Georges,, Mathias Hallberg, Máté Erdélyi, Anders Karlén, Demaegdt, Heidi,   +17 more
core   +1 more source