Results 111 to 120 of about 3,708 (156)

Angiotensin IV Receptors in the Rat Prefrontal Cortex: Neuronal Expression and NMDA Inhibition

Biomedicines
Background: N-methyl-D-aspartate type glutamate receptors (NMDARs) are fundamental to neuronal physiology and pathophysiology. The prefrontal cortex (PFC), a key region for cognitive function, is heavily implicated in neuropsychiatric disorders ...
Zsolt Tamás Papp, Polett Ribiczey, Erzsébet Kató, Zsuzsanna E. Tóth, Zoltán V. Varga, Zoltán Giricz, Adrienn Hanuska, Mahmoud Al-Khrasani, Ákos Zsembery, Tibor Zelles, Laszlo G. Harsing, László Köles   +11 more
doaj   +1 more source

Disulfide Cyclized Tripeptide Analogues of Angiotensin IV as Potent and Selective Inhibitors of Insulin-Regulated Aminopeptidase (IRAP)

, 2016
The insulin-regulated aminopeptidase (IRAP) localized in areas of the brain associated with memory and learning is emerging as a new promising therapeutic target for the treatment of memory dysfunctions.
Hanna Andersson (1408987), Mathias Hallberg (1656958), Anders Karlén (1281249), Gunnar Lindeberg (492163), Anders Hallberg (585061), Heidi Demaegdt (470499), Georges Vauquelin (2136157), Máté Erdélyi (1364241)   +7 more
core   +1 more source

Putative Involvement of Endocrine Disruptors in the Alzheimer's Disease Via the Insulin-Regulated Aminopeptidase/GLUT4 Pathway. [PDF]

Curr Neuropharmacol, 2021
Ramírez-Expósito MJ, Martínez-Martos JM, Cantón-Habas V, Del Pilar Carrera-González M.   +3 more
europepmc   +1 more source

Potent Macrocyclic Inhibitors of Insulin-Regulated Aminopeptidase (IRAP) by Olefin Ring-Closing Methatesis

, 2011
Macrocyclic analogues of angiotensin IV (Ang IV, Val1-Tyr2-Ile3-His4-Pro5-Phe6) targeting the insulin-regulated aminopeptidase (IRAP) have been designed, synthesized, and evaluated biologically.
Demaegdt, H, Karlén, Anders, Erdelyi, Mate,, Lindeberg, G, Hallberg, Anders, Andersson, Hanna, ´Vaquelin, G, Hallberg, Matthias, Johansson, Anja   +8 more
core  

Synthesis of Insulin-Regulated Aminopeptidase (IRAP) inhibitors

, 2015
The need for alternative cognitive enhancers has risen due to the fact that clinical trial results of the drugs currently approved for treating these disorders have not been satisfactory. IRAP has become a possible drug target for treating cognitive impairment brought about by Alzheimer’s disease, head trauma or cerebral ischemia, among others.
openaire   +1 more source

Molecular characterization of insulin-regulated aminopeptidase (IRAP)

, 2006
© 2006 Dr. Siying YeCentral infusion of the hexapeptide angiotensin IV (Ang IV) and its analogs have been demonstrated to markedly enhance memory retention and retrieval in rats using a range of learning and memory paradigms.
Ye, Siying
core  

Novel macrocyclic peptidomimetics targeting the insulin-regulated aminopeptidase (IRAP): design, synthesis and evaluation. [PDF]

RSC Med Chem
Olaniran Håkansson E, Balestri LJI, Puthiyaparambath S, Moes S, Henschel H, Sköld C, Hallberg M, Larhed M, Skillinghaug B, Odell LR.   +9 more
europepmc   +1 more source

Insulin-regulated aminopeptidase deficiency impairs cardiovascular adaptations and placental development during pregnancy. [PDF]

Clin Sci (Lond), 2020
Walton SL, Mirabito Colafella KM, Ansari A, Chai SY, Denton KM.   +4 more
europepmc   +1 more source

Quantum Mechanics/Molecular Mechanics Simulations Distinguish Insulin-Regulated Aminopeptidase Substrate (Oxytocin) and Inhibitor (Angiotensin IV) and Reveal Determinants of Activity and Inhibition. [PDF]

J Chem Inf Model
Hanževački M, Twidale RM, Lang EJM, Gerrard W, Wright DW, Stojevic V, Mulholland AJ.   +6 more
europepmc   +1 more source

Electroosmotic Perfusion-Microdialysis Probe Created by Direct Laser Writing for Quantitative Assessment of Leucine Enkephalin Hydrolysis by Insulin-Regulated Aminopeptidase in Vivo. [PDF]

Anal Chem, 2020
Wilson RE, Jaquins-Gerstl A, Chen J, Rerick M, Weber SG.   +4 more
europepmc   +1 more source