Results 101 to 110 of about 3,708 (156)

Potent Macrocyclic Inhibitors of Insulin-Regulated Aminopeptidase (IRAP) by Olefin Ring-Closing Metathesis

, 2016
Macrocyclic analogues of angiotensin IV (Ang IV, Val1-Tyr2-Ile3-His4-Pro5-Phe6) targeting the insulin-regulated aminopeptidase (IRAP) have been designed, synthesized, and evaluated biologically.
Hanna Andersson (1408987), Mathias Hallberg (1656958), Anders Karlén (1281249), Gunnar Lindeberg (492163), Anders Johnsson (2193301), Anders Hallberg (585061), Heidi Demaegdt (470499), Georges Vauquelin (2136157), Máté Erdélyi (1364241)   +8 more
core   +1 more source

Sexual and Metabolic Differences in Hippocampal Evolution: Alzheimer’s Disease Implications

Life
Sex differences in brain metabolism and their relationship to neurodegenerative diseases like Alzheimer’s are an important emerging topic in neuroscience.
José Manuel Martínez-Martos, Vanesa Cantón-Habas, Manuel Rich-Ruíz, María José Reyes-Medina, María Jesús Ramírez-Expósito, María del Pilar Carrera-González   +5 more
doaj   +1 more source

Cognitive-enhancing effects of angiotensin IV

BMC Neuroscience, 2008
Angiotensin IV is a derivative of the potent vasoconstrictor angiotensin II and it has been shown to enhance acquisition, consolidation and recall in animal models of learning and memory when administered centrally or peripherally.
Gard Paul R
doaj   +1 more source

Insulin-regulated aminopeptidase inhibitors do not alter glucose handling in normal and diabetic rats

, 2017
Insulin-regulated aminopeptidase (IRAP) co-localizes with the glucose transporter 4 (GLUT4) in GLUT4 storage vesicles (GSV) in insulin-responsive cells.
Cacador, M, Anthony L Albiston, Chai, Siew Yeen, Siew Yeen Chai, Albiston, Anthony, Burns, P, Peta Burns, Sinnayah, Puspha, Burns, Peta, Puspha Sinnayah, Mauricio Cacador, Cacador, Mauricio, Chai, SY   +12 more
core   +1 more source

Binding to and Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Macrocyclic Disulfides Enhances Spine Density

, 2016
Angiotensin IV (Ang IV) and related peptide analogues, as well as non-peptide inhibitors of insulin-regulated aminopeptidase (IRAP), have previously been shown to enhance memory and cognition in animal models.
Lundback, Thomas, Hallberg, Mathias,, Nylander, Erik,, Pham, Vi, Engen, Karin,, Larhed, Mats,, Diwakarla, Shanti,, Sävmarker, Jonas,, Åqvist, Johan,, Grönbladh, Alfhild,, Andersson, Hanna,, Rosenström, Ulrika,, Gutierrez-de-Teran, Hugo,, Shamsudin Khan, Yasmin,, Jenmalm-Jensen, Annika, Reddy Vanga, Sudarsana,, Ng, Leelee, Yeen Chai, Siew   +17 more
core   +1 more source

Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP)

, 2003
Angiotensin IV (Ang IV) exerts profound effects on memory and learning, a phenomenon ascribed to its binding to a specific AT4 receptor. However the AT4 receptor has recently been identified as the insulin-regulated aminopeptidase (IRAP).
Siying Ye (13094898), R Lew (13471534), S Chai (9882683), T Mustafa (13733881), S McDowall (13733884), A Albiston (13732981)   +5 more
core  

Fetal pancreas size and maternal serum biomarkers glycated albumin and insulin-regulated aminopeptidase provide no potential for early prediction of gestational diabetes mellitus. [PDF]

Arch Gynecol Obstet, 2023
Guleroglu FY, Ozmen AB, Bakirci IT, Dogu SY, Yılmaz I, Cetin A.   +5 more
europepmc   +1 more source

Inhibitors Targeting Insulin-Regulated Aminopeptidase (IRAP) : Identification, Synthesis and Evaluation

, 2020
Insulin-regulated aminopeptidase (IRAP) has emerged as a potential new therapeutic target for treatment of cognitive disorders. Inhibition of the enzymatic activity facilitates cognition in rodents.
Engen, Karin
core  

Disulfide Cyclized Tripeptide Analogues of Angiotensin IV as Potent and Selective Inhibitors of Insulin-Regulated Aminopeptidase (IRAP)

, 2010
The insulin-regulated aminopeptidase (IRAP) localized in areas of the brain associated with memory and learning is emerging as a new promising therapeutic target for the treatment of memory dysfunctions.
Karlén, Anders,, Lindeberg, Gunnar,, Anders Hallberg, Hallberg, Mathias,, Heidi Demaegdt, Georges Vauquelin, Hallberg, Anders,, Gunnar Lindeberg, Andersson, Hanna,, Erdélyi, Máté, Hanna Andersson, Vauquelin, Georges,, Mathias Hallberg, Máté Erdélyi, Anders Karlén, Demaegdt, Heidi,   +15 more
core   +1 more source

Insulin-regulated aminopeptidase inhibitor C9 restores cellular activity in methadone-damaged primary cell cultures

Insulin-regulated aminopeptidase (IRAP) is emerging as a pharmaceutical target for treatment of neurotoxic- and neurodegenerative symptoms commonly seen in cognitive impairments.
Stam, Frida, Olaniran Håkansson, Esther, Lind, Sara Florén, Grönbladh, Alfhild, Larhed, Mats, Hallberg, Mathias, Nylander, Erik, Odell, Luke R., Gising, Johan   +8 more
core   +1 more source