Results 131 to 140 of about 3,708 (156)

Mechanisms of Allosteric Inhibition of Insulin-Regulated Aminopeptidase

Journal of Molecular Biology
Inhibition of Insulin-Regulated Aminopeptidase is being actively explored for the treatment of several human diseases and several classes of inhibitors have been developed although no clinical applications have been reported yet. Here, we combine enzymological analysis with x-ray crystallography to investigate the mechanism employed by two of the most ...
Anastasia Mpakali, Ioanna Barla, Liying Lu   +2 more
exaly   +5 more sources

Presence and regulation of insulin-regulated aminopeptidase in mouse macrophages [PDF]

JRAAS - Journal of the Renin-Angiotensin-Aldosterone System, 2014
Introduction: The insulin-regulated aminopeptidase (IRAP) is expressed in several cell types, where it is mainly located in specialized secretory endosomes that are quickly recruited to the cell surface upon cell type-specific activation.
Alexandros Nikolaou, Benoit Stijlemans, Damya Laoui   +2 more
exaly   +4 more sources

Vasopressin is a physiological substrate for the insulin-regulated aminopeptidase IRAP [PDF]

American Journal of Physiology - Endocrinology and Metabolism, 2007
Insulin-regulated aminopeptidase (IRAP) is a membrane aminopeptidase and is homologous to the placental leucine aminopeptidase, P-LAP. IRAP has a wide distribution but has been best characterized in adipocytes and myocytes. In these cells, IRAP colocalizes with the glucose transporter GLUT4 to intracellular vesicles and, like GLUT4, translocates from ...
Susanna R Keller
exaly   +3 more sources

Mutational analysis of the active site of human insulin-regulated aminopeptidase [PDF]

FEBS Journal, 2001
Insulin‐regulated aminopeptidase (IRAP) is a type II integral membrane protein belonging to the gluzincin family of metallopeptidases identified by the characteristic Zn2+‐coordination sequence element, HEXXH‐(18–64X)‐E. A second conserved sequence element, the GXMEN motif, positioned 22–32 amino acids N‐terminal to the Zn2+‐coordination sequence ...
Søren Vang
exaly   +5 more sources

Role of the Insulin-Regulated Aminopeptidase IRAP in Insulin Action and Diabetes

Biological and Pharmaceutical Bulletin, 2004
The insulin-regulated aminopeptidase (IRAP) is a member of the family of zinc-dependent membrane aminopeptidases. It is the homolog of the human placental leucine aminopeptidase (P-LAP). IRAP is expressed in different cell types but has been best characterized in two major insulin target cells, muscle and fat.
exaly   +4 more sources

Antidepressant-like effects of oxytocin in mice are dependent on the presence of insulin-regulated aminopeptidase

International Journal of Neuropsychopharmacology, 2013
Oxytocin is a neuromodulator with antidepressant-like effects. In vitro, oxytocin is rapidly cleaved by insulin-regulated aminopeptidase (IRAP). Oxytocin metabolites are known to exert strong central activities that are different from the effects of the ...
Ellen Loyens, Dimitri De Bundel, Heidi Demaegdt   +2 more
exaly   +2 more sources

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Vasopressin inactivation: Role of insulin-regulated aminopeptidase

2020
The physiological importance of vasopressin inactivation has long been appreciated, but the mechanisms and potential pathophysiologic roles of this process remain active subjects of research. Human Placental Leucine Aminopeptidase (P-LAP, encoded by the LNPEP gene) is an important determinant of vasopressinase activity during pregnancy and is ...
Don T, Li, Estifanos N, Habtemichael, Jonathan S, Bogan   +2 more
openaire   +2 more sources

Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures

ACS Chemical Neuroscience, 2016
The zinc metallopeptidase insulin regulated aminopeptidase (IRAP), which is highly expressed in the hippocampus and other brain regions associated with cognitive function, has been identified as a high-affinity binding site of the hexapeptide angiotensin
Shanti Diwakarla, Sudarsana Reddy Vanga, Yasmin Shamsudin   +2 more
exaly   +2 more sources

Insulin-Regulated Aminopeptidase

2004
Although insulin-regulated aminopeptidase (IRAP) was first described as a marker protein for specialized vesicles containing the insulin-responsive glucose transporter, GLUT4, the protein has subsequently been shown to be identical to oxytocinase or the AT4 receptor.
Siew Yeen Chai, Ruani Fernando, Siying Ye, Grantley R. Peck, Anthony L. Albiston   +4 more
openaire   +1 more source