Results 141 to 150 of about 3,708 (156)

Social behaviour is altered in the insulin-regulated aminopeptidase knockout mouse

Behavioural Brain Research, 2019
Oxytocin, and the closely related neuropeptide, vasopressin, are both known to modulate social behaviours. The pro-social effects of oxytocin are well-documented and have generated much interest into its suitability as a therapeutic for disorders characterised by social dysfunction.
James D Mcfadyen, Anthony L Albiston, Vi Pham   +2 more
exaly   +3 more sources

Insulin-regulated aminopeptidase and its compartment in dendritic cells

Molecular Immunology, 2013
Peptide epitopes presented by MHC class I molecules are produced through sequential proteolysis, frequently terminating with an aminoterminal trimming step. While the trimming enzymes processing endogenous MHC class I ligands in the endoplasmic reticulum have by now been characterized extensively, we have only recently identified an endosomal enzyme ...
Loredana, Saveanu, Joël, Babdor, Myriam, Lawand, Peter, van Endert   +3 more
openaire   +2 more sources

The insulin-regulated aminopeptidase a companion and regulator of GLUT4

Frontiers in Bioscience, 2003
The insulin-regulated membrane aminopeptidase (IRAP) was originally identified in fat and muscle cells as a major protein in intracellular vesicles that also harbor the insulin-responsive glucose transporter GLUT4. IRAP, like GLUT4, predominantly localizes to these intracellular vesicles under basal conditions.
openaire   +2 more sources

Insulin stimulates placental leucine aminopeptidase/oxytocinase/insulin-regulated membrane aminopeptidase expression in BeWo choriocarcinoma cells

Regulatory Peptides, 2004
Placental leucine aminopeptidase (P-LAP), a cystine aminopeptidase that is identical to insulin-regulated membrane aminopeptidase, hydrolyzes oxytocin, which results in the loss of oxytocin activity. We previously isolated genomic clones containing the human P-LAP promoter region, which included two sites homologous to the 10-bp-insulin responsive ...
Masayuki, Nakata, Seiji, Nomura, Yoko, Ikoma, Seiji, Sumigama, Fumi, Shido, Tomomi, Ito, Mayumi, Okada, Fumitaka, Kikkawa, Masafumi, Tsujimoto, Shigehiko, Mizutani   +9 more
openaire   +2 more sources

Distinct distribution of GLUT4 and insulin regulated aminopeptidase in the mouse kidney

Regulatory Peptides, 2011
The physiological importance of the insulin responsive glucose transporter GLUT4 in adipocytes and muscle in maintaining glucose homeostasis is well established. A key protein associated with this process is the aminopeptidase IRAP which co-localizes with GLUT4 in specialized vesicles, where it plays a tethering role. In this study, we investigated the
Albiston, Anthony L, Yeatman, Holly R, Pham, Vi, Fuller, Stephanie J, Diwakarla, Shanti, Fernando, Ruani N, Chai, Siew Yeen   +6 more
openaire   +2 more sources

Cyclic insulin‐regulated aminopeptidase (IRAP)/AT₄ receptor ligands

Journal of Peptide Science, 2006
AbstractThe angiotensin IV receptor (AT4 receptor) is the insulin‐regulated aminopeptidase enzyme (IRAP, EC 3.4.11.3). This membrane‐spanning enzyme belongs to the M1 family of zinc‐dependent metallo‐peptidases. It has been proposed that AT4 receptor ligands exert their physiological effects by binding to the active site of IRAP and thereby inhibiting ...
Axen, A., Lindberg, G., Demaegdt, Heidi, Vauquelin, Georges, Karlen, A., Hallberg, M.   +5 more
openaire   +3 more sources

Reproduction and maternal behavior in insulin-regulated aminopeptidase (IRAP) knockout mice

Peptides, 2009
During human pregnancy, a circulating form of insulin-regulated aminopeptidase (IRAP EC 3.4.11.3), often termed oxytocinase or placental leucine aminopeptidase (PLAP), is present in plasma. It is proposed that circulating IRAP plays an important role in regulating the circulating levels of oxytocin and/or vasopressin during pregnancy.
Vi, Pham, Peta, Burns, Anthony L, Albiston, Holly R, Yeatman, Leelee, Ng, Shanti, Diwakarla, Siew Yeen, Chai   +6 more
openaire   +2 more sources

Identification of modulating residues defining the catalytic cleft of insulin-regulated aminopeptidase

Biochemistry and Cell Biology, 2008
Inhibition of insulin-regulated aminopeptidase (IRAP) has been demonstrated to facilitate memory in rodents, making IRAP a potential target for the development of cognitive enhancing therapies. In this study, we generated a 3-D model of the catalytic domain of IRAP based on the crystal structure of leukotriene A4 hydrolase (LTA4H).
Ye, Siying, Chai, Siew Yeen, Lew, Rebecca A, Ascher, David B, Morton, Craig J, Parker, Michael W, Albiston, Anthony L   +6 more
openaire   +3 more sources

Cystinyl aminopeptidase, oxytocinase and insulin-regulated aminopeptidase

2004
Seiji Nomura, Masafumi Tsujimoto, Shigehiko Mizutani   +2 more
openaire   +1 more source

Insulin-regulated aminopeptidase: a novel target for antiepileptic drugs?

2008
OBJECTIVES: Investigation of the potential of insulin-regulated aminopeptidase (IRAP) as a novel target for antiepileptic drugs. BACKGROUND: The neuropeptide somatostatin is an important regulator of hippocampal excitability and several lines of evidence implicate its involvement in temporal lobe epilepsy.
De Bundel, Dimitri, Loyens, Ellen, Aourz, Najat, Stragier, Bart, Michotte, Yvette, Smolders, Ilse Julia   +5 more
openaire   +1 more source