Results 61 to 70 of about 3,708 (156)

Regulation of Insulin-Regulated Membrane Aminopeptidase Activity by Its C-Terminal Domain

Biochemistry, 2011
The development of inhibitors of insulin-regulated aminopeptidase (IRAP), a membrane-bound zinc metallopeptidase, is a promising approach for the discovery of drugs for the treatment of memory loss such as that associated with Alzheimer's disease. There is, however, no consensus in the literature about the mechanism by which inhibition occurs. Sequence
Ascher, David B., Cromer, Brett A., Morton, Craig J., Volitakis, Irene, Cherny, Robert A., Albiston, Anthony L., Chai, Siew Yeen, Parker, Michael W.   +7 more
openaire   +6 more sources

Genetic Parameters and Genome‐Wide Association Studies for Fertility and Reproduction Traits in U.S. Katahdin Sheep Based on the Single‐Step GBLUP Methodology

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Sheep production contributes to a secure and diverse food and fibre supply in the United States, with growing ethnic diversity strengthening demand. Katahdin is a composite hair‐type sheep breed developed in the United States that has become the most popular breed in many regions of the country and the first one to have genomic selection ...
Alejandra Toro Ospina, Ronald M. Lewis, Bradley A. Freking, Joan M. Burke, Thomas W. Murphy, Carrie S. Wilson, Luiz F. Brito   +6 more
wiley   +1 more source

INSULIN AND INSULIN RESISTANCE: NEW MOLECULE MARKERS AND TARGET MOLECULE FOR THE DIAGNOSIS AND THERAPY OF DISEASES OF THE CENTRAL NERVOUS SYSTEM

Бюллетень сибирской медицины, 2013
The review summarizes current data on the role of insulin in the regulation of t glucose metabolism in the central nervous system at physiologic and pathologic conditions.
A. B. Salmina, N. A. Yauzina, N. V. Kuvacheva, M. M. Petrova, T. Ye. Taranushenko, N. A. Malinovskaya, O. L. Lopatina, A. V. Morgun, Ye. A. Pozhilenkova, O. S. Okuneva, G. A. Morozova, S. V. Prokopenko   +11 more
doaj   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, Volume 293, Issue 13, Page 3899-3953, July 2026.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma

eFood, Volume 7, Issue 3, June 2026.
Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie, Wei Fang, Zean Song, Zhang Yu, Ying Zhu, Shaoping Liu   +5 more
wiley   +1 more source

Mast cell-mediated inflammation relies on insulin-regulated aminopeptidase controlling cytokine export from the Golgi

, 2023
International audienceBackground: Upon activation, mast cells rapidly release preformed inflammatory mediators from large cytoplasmic granules via regulated exocytosis.
Carvalho, Caroline, Weimershaus, Mirjana, van Endert, Peter, Maciel, Thiago Trovati, Rignault, Rachel, Waeckel-Enee, Emmanuelle, Dussiot, Michael, Hermine, Olivier   +7 more
core   +1 more source

Structural basis for dimerization, catalytic regulation, and substrate selectivity of the chloroplast S9D CGEP protease in Arabidopsis thaliana

Protein Science, Volume 35, Issue 6, June 2026.
Abstract S9 proteases are widely distributed across the tree‐of‐life and play essential roles in protein processing. However, the structural and mechanistic basis for protease activity in the S9D subfamily, restricted to photosynthetic eukaryotes (e.g., plants), cyanobacteria, proteobacteria and flavobacteria, is unknown. Here, we report the first high‐
Jacqueline J. Ehrlich, Pratyush Routray, Louis Enns, Klaas J. van Wijk, Toshimitsu Kawate   +4 more
wiley   +1 more source

Discovery of Selective Nanomolar Inhibitors for Insulin-Regulated Aminopeptidase Based on α‑Hydroxy-β-amino Acid Derivatives of Bestatin

, 2022
The oxytocinase subfamily of M1 zinc aminopeptidases comprises emerging drug targets, including the ER-resident aminopeptidases 1 and 2 (ERAP1 and ERAP2) and insulin-regulated aminopeptidase (IRAP); however, reports on clinically relevant inhibitors are ...
Ioannis Temponeras (13044466), Efstratios Stratikos (340662), Despoina Koumantou (3777826), Victoria Magrioti (448335), Athanasios Papakyriakou (375921), Petros Giastas (2942250), Ioannis Mavridis (67428), Dionisios Vourloumis (1396891), Anastasia Mpakali (3127524), Alexandros Athanasoulis (13044463), Jacqueline Leib (13044469), Peter van Endert (13044472)   +11 more
core   +3 more sources

Recent Advances in Egg White Biotechnology, Microbiology, and Quality

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT International trade in egg products has increased in recent decades to meet the rising demands of a global population, the food industry, and consumers. Egg white is a rich source of proteins and peptides suitable for various food applications. Processing egg whites is important in the food industry.
Insa Mannott, Ramona Bosse, Monika Gibis
wiley   +1 more source

Bioactive Peptide‐Enriched Requeson: A Functional Dairy Product From Whey Fermentation

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
This study presents the production of functional Requeson from whey using lactic fermentation. Proteolysis induced by Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus thermophilus promotes the generation of bioactive peptides. The product is evaluated for antioxidant, ACE‐inhibitory, DPP‐IV inhibitory, mineral chelating, and antimicrobial ...
Luis‐Fernando Patlan‐Velázquez, Luis‐Guillermo González‐Olivares, Mariano García‐Garibay, Sergio Alatorre‐Santamaría, Lorena Gómez‐Ruiz, Gabriela Rodríguez‐Serrano, Ulises Carrasco‐Navarro, Alma Cruz‐Guerrero   +7 more
wiley   +1 more source