Comparative study of Dapagliflozin versus Glimepiride effect on insulin regulated aminopeptidase (IRAP) and interleukin-34 (IL-34) in patient with type 2 diabetes mellitus [PDF]
Scientific Reports, 2023 Type 2 diabetes mellitus (T2DM) is one of the most common diseases, that managed by several medications such as Glimepiride and Dapagliflozin. This study aims to compare the effects of Dapagliflozin versus Glimepiride on glycemic control, insulin ...
Rania Zekry +3 more
doaj +2 more sources
Inhibition of Insulin-Regulated Aminopeptidase by Imidazo [1,5-α]pyridines—Synthesis and Evaluation [PDF]
International Journal of Molecular SciencesInhibition of Insulin-regulated Aminopeptidase (IRAP) has been shown to improve cognitive functions in several animal models. Recently, we performed a screening campaign identifying novel small-molecule based compounds acting as inhibitors of the ...
Karin Engen +2 more
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Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase. [PDF]
BMC Neurosci, 2008 The peptides angiotensin IV and LVV-hemorphin 7 were found to enhance memory in a number of memory tasks and reverse the performance deficits in animals with experimentally induced memory loss. These peptides bound specifically to the enzyme insulin-regulated aminopeptidase (IRAP), which is proposed to be the site in the brain that mediates the memory ...
Chai SY +6 more
europepmc +9 more sources
Therapeutic targeting of insulin-regulated aminopeptidase: Heads and tails?
Pharmacology & Therapeutics, 2007 Insulin-regulated aminopeptidase, IRAP, is an abundant protein that was initially cloned from a rat epididymal fat pad cDNA library as a marker protein for specialized vesicles containing the insulin-responsive glucose transporter GLUT4, wherein it is thought to participate in the tethering and trafficking of GLUT4 vesicles.
Albiston, Anthony L +5 more
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The effects of insulin-regulated aminopeptidase inhibition with HA08 on recognition memory acquisition and spatial working memory under reversed circadian conditions in male rats [PDF]
IBRO Neuroscience ReportsIn 1995, a new M1 aminopeptidase member was discovered in fat and muscle cells, the insulin regulated aminopeptidase (IRAP; oxytocinase; placental leucine aminopeptidase).
Frida Stam +7 more
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Conformational Changes in Insulin Regulated Aminopeptidase
, 2021 Global disease burden due to age related cognitive decline and dementias, especially Alzheimer’s disease, are a growing public health problem. Current treatments fail to completely prevent or cure dementia. A target of interest is the Insulin Regulated Aminopeptidase (IRAP) enzyme, inhibitors of IRAP have shown promise in preventing and reversing ...
Moes, Sebastian
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Targeting the insulin-regulated aminopeptidase/AT4 receptor for cognitive disorders
Drug News & Perspectives, 2009 The insulin-regulated aminopeptidase/AT(4) receptor has recently emerged as a new target for pharmaceutical agents aimed at treating various cognitive disorders such as Alzheimer's disease. There is an unmet need for metabolically stable drug-like angiotensin (Ang) IV analogues that exert actions mimicking the powerful memory-enhancing effects of Ang ...
Halberg, M., Hallberg, Mathias,
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Effects of ligands or substrate of insulin‐regulated aminopeptidase (IRAP) on trophoblast invasion
Journal of Peptide Science, 2008 AbstractInsulin‐regulated aminopeptidase (IRAP) activity increases during placentation and in the invasive tumor cell of trophoblast suggesting a role for this peptidase in the invasiveness of normal and malignant trophoblast. To investigate this hypothesis, we studied the effects of substrate (OT) and inhibitors (angiotensin peptides and LVV‐H7) of ...
Cohen, Marie-Benoîte +3 more
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Affinity between TBC1D4 (AS160) phosphotyrosine-binding domain and insulin-regulated aminopeptidase cytoplasmic domain measured by isothermal titration calorimetry [PDF]
BMB Reports, 2012 Uptake of circulating glucose into the cells happens via the insulin-mediated signalling pathway, which translocates the glucosetransporter 4 (GLUT4) vesicles from the intracellular compartmentto the plasma membrane.
SangYoun Park*, Keon Young Kim, Sunmin Kim & Young Seok Yu
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Insulin-regulated aminopeptidase is required for water excretion in response to acute hypotonic stress [PDF]
American Journal of Physiology - Renal Physiology, 2023 Yvonne Zuchowski +2 more
exaly +2 more sources