Results 171 to 180 of about 37,349 (239)

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, Volume 13, Issue 55, 5 October 2026.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

G3BP1 methylation by PRMT5 facilitates its recruitment of TBK1 for IRF3 activation during host response to foreign ribonucleic acids. [PDF]

Front Immunol
Song W, Kim SS, Yam C, Teo J, Lim JY, Bi X, Lim HH, Lam KP.   +7 more
europepmc   +1 more source

ER Stress Regulates HIV Tat and Alcohol‐Induced NLRP6 Activation in Astrocytes

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
HIV Tat and ethanol synergistically induce ER stress in astrocytes, activating an ER stress‐NLRP6 inflammasome axis that drives caspase‐1 activation and IL‐1β/IL‐18 release. Targeting ER stress or NLRP6 effectively suppresses astrocytic neuroinflammation, identifying a novel therapeutic pathway for alcohol‐exacerbated NeuroHIV.
Seema Singh, Elias Horanieh, Shilpa Buch, Palsamy Periyasamy   +3 more
wiley   +1 more source

AIM2 Lactylation Regulates Radiotherapy Sensitivity in Triple-Negative Breast Cancer. [PDF]

Breast Cancer (Dove Med Press)
Chen J, Zhao Z, Xing Y, Li X, Liu D, Liu L, Yang M, Zhou H, Wang J, Wu Q.   +9 more
europepmc   +1 more source

FBXO11 and FBXO32 synergistically activate innate immunity against hepatitis B virus in a NEDD8-dependent manner. [PDF]

Front Immunol
Li L, Tao S, Zhang Y, Zeng Z, Li L, Zhang J.   +5 more
europepmc   +1 more source

Dual Antiviral and Immunomodulatory Effects of Phytochemicals in Influenza A Virus Infection: Targeting Key Host Signaling Pathways

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Influenza A virus modulates host innate immune pathways, including TLR, RIG‐I, MAPK, and NF‐κB signaling, to support replication and drive inflammatory pathology. Plant‐derived phytocompounds target these interconnected pathways, offering a potential host‐directed immunomodulatory approach complementary to conventional antivirals.
Dibakar Chowdhury, Hillary A. Vanderven, Phurpa Wangchuk, Subir Sarker   +3 more
wiley   +1 more source

NAT10 is critical to block RNA sensing-induced IFN-β transactivation in viral infection. [PDF]

mBio
Park Y, Liu Y, He J, Eleya S, Wu Z, Fiches GN, Zhou D, Watters EG, He ZM, Shanaka KASN, Lepcha TT, Yount JS, Santoso NG, Zhu J.   +13 more
europepmc   +1 more source

Posttranslational Modifications of p62/SQSTM1 in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Schematic illustration of p62 as a posttranslational modifications (PTMs)‐programmed integrator in homeostasis, pathogenesis, and therapeutic targeting. (Left) Homeostasis: In physiological states, p62, through various PTMs such as phosphorylation, ubiquitination, and acetylation, coordinates essential cellular functions.
Weikai Wang, Xin Jiang, Runing Qiu, Chandra Sugiarto Wijaya, Miaoqin Chen, Jin Wang, Liyuan Zhu, Hongchuan Jin, Lifeng Feng   +8 more
wiley   +1 more source

Plakophilin 1 suppresses keratinocyte innate immune responses through DExD/H helicases. [PDF]

Cell Mol Immunol
Keil R, Misiak D, Hüttelmaier S, Tellkamp F, Krüger M, Hatzfeld M.   +5 more
europepmc   +1 more source

Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 10, October 2026.
Skeletal muscle aging is driven by coordinated local breakdown across myofibers, stem and stromal cells, immune and vascular compartments, and neuromuscular control. These mechanisms promote mitochondrial dysfunction, inflammation, senescence, impaired regeneration, fibrosis, myosteatosis, denervation, and functional decline.
Ting Liu, Yaomin Hu
wiley   +1 more source