Results 151 to 160 of about 31,611 (205)

Ursodeoxycholic acid inhibits feline infectious peritonitis virus infection through activating JAK-STAT signaling pathway-induced type I interferon. [PDF]

Microbiol Spectr
Zhong Y, Sun Z, Song Z, Ding J, Song Y, Li Y, Liao G, Wang X, Zeng Y, Hu N, Zhang X, Song Z.   +11 more
europepmc   +1 more source

An Engineered Nano‐Bridging Strategy Remodels the Immune Microenvironment of Esophageal Squamous Cell Carcinoma via STING Pathway Activation

MedComm, Volume 7, Issue 6, June 2026.
HA1@diABZI–HMGB1 serves as a synergistic immunomodulator for dismantling the immunosuppressive microenvironment of esophageal squamous cell carcinoma (ESCC), it integrates ESCC‐targeted recognition, HMGB1‐mediated macrophage–tumor cell bridging, and diABZI‐driven STING activation.
Chaofan Huang, Xin Tang, Yixiao Zhao, Dafu Xu, Congyong Sun, Chenlong Wang, Fei Xie, Fangyi Xu, Chao Luo, Li Zhang, Qilong Wang   +10 more
wiley   +1 more source

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, Volume 2, Issue 2, Page 280-308, June 2026.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source

Pestivirus bovine viral diarrhea virus infection induces ROS-HIF-1a axis-driven glycolytic reprogramming, which increases viral replication by impairing RIG-I-dependent type I interferon response. [PDF]

J Virol
Li Y, Zhou J, Wang J, Yan K, Guan Y, Wang M, Xiang J, Liu Y, Yu H, Jia S, Yang W, Xu Y.   +11 more
europepmc   +1 more source

Inflammation, Immunity, and Cardiovascular Diseases

Med Research, Volume 2, Issue 2, Page 343-370, June 2026.
Cardiovascular stress signals (e.g., hemodynamic shear, oxidized lipids, and ischemia) act on endothelial and immune cells to activate and amplify inflammation through NF‐κB, the NLRP3 inflammasome, and JAK/STAT signaling, inducing proinflammatory cytokines/chemokines (IL‐6, IL‐1β, TNF‐α, and CCL2) and self‐amplifying circuits; clinically, inflammatory
Dezhi Guo, Yan Liao, Rui Zhao, Zhaoyu Li, Kaikai Wang, Haoling Zhang, Pingxin Sun, Yadong Guo, Wangzheqi Zhang   +8 more
wiley   +1 more source

Harnessing Trace Elements: Novel Radiosensitization Strategies for Enhanced Cancer Radiotherapy

Rare Metals, Volume 45, Issue 6, June 2026.
ABSTRACT Radiotherapy (RT) is one of the core methods of comprehensive cancer treatment. Globally, more than 40% of cancer patients rely on radiotherapy to achieve tumor control, cure or palliative relief. However, radiation resistance, immunosuppression and normal tissue injury limit its clinical application.
Yuhuan Zhang, Yizhi Ge, Hongguang Xiang, Ji Liu, Yu Tian, Yan Shen, Dan Zong   +6 more
wiley   +1 more source

<i>Escherichia coli JNL-EC1</i> enhances type I IFN-mediated antiviral response during DNA and RNA virus infection. [PDF]

Front Microbiol
Li R, Pan Z, Wang N, Zhang S, Geng X, Yu Y, Shi J, Liu C, Jin C, Shang L, Wu H, Wu N.   +11 more
europepmc   +1 more source

Mn²⁺-Mediated Antiviral Activity Through Both the cGAS-STING-IFN and ROS-Apoptosis Pathways in Porcine Alveolar Macrophage Cells. [PDF]

Vet Sci
Zheng W, Chang Y, Liu A, Zhang C, Hao W, Chen T, Lu Q, Wang Z, Wang W, Chen N, Zhu J.   +10 more
europepmc   +1 more source

Magnetic Reprogramming of Macrophages Stimulates Phagocytosis of Breast Cancer Cells via a TRPC1‐STING Inflammatory Axis

Smart Medicine, Volume 5, Issue 3, June 2026.
Magnetic fields modulate macrophage‐cancer crosstalk through the STING‐TRPC1 axis. Exposure reprograms macrophages toward the anti‐cancer phenotype. Exposing cancer cells modulates cancer secretome to promote polarization and selective recruitment of M1‐tumoricidal macrophages, enhancing cancer immunogenicity.
Viresh Krishnan Sukumar, Yee Kit Tai, Jan Nikolas Iversen, Olivia Yeo, Anisha Praiselin Paul, Kwan Yu Wu, Lina Hsiu Kim Lim, Alfredo Franco‐Obregón   +7 more
wiley   +1 more source

Porcine reproductive and respiratory syndrome virus N protein-mediated viral replication enhancement via interaction with host caspase-6. [PDF]

J Virol
Zhu D, Fu C, Dong Y, Zhang Q, Li H, Sun Y, Zhang G, Wang H.   +7 more
europepmc   +1 more source