Results 131 to 140 of about 31,611 (205)

BRCA1 deficiency induces NFκB-dependent type-I interferon signaling in fallopian tube epithelial cells. [PDF]

Neoplasia
Madaan V, Kollara A, Spaner D, Brown TJ.
europepmc   +1 more source

Control of poorly immunogenic tumors with systemic STING agonist‐loaded liposomes targeting cross‐presenting dendritic cells

Clinical &Translational Immunology, Volume 15, Issue 6, 2026.
WH‐peptide‐functionalised liposomes encapsulating STING or RIG‐I agonists target intra‐tumoral Clec9A+ cDC1 and pDC, triggering release of type 1 IFN, presentation of CD4 and CD8 endogenous tumor epitopes, expansion of CTL with help from CD4 T cells in spleen, and tumor cell killing.
Bijun Zeng, Meghna Talekar, Thais Aragao‐Horoiwa, Amy Cameron, Guangzu Zhao, Yulia Zybina, Wendy Blumenschein, Karyn van de Mark, Wittaya Suwakulsiri, Gretchen A Baltus, Riccardo Dolcetti, Ranjeny Thomas   +11 more
wiley   +1 more source

Characterization of a transmembrane-activating STING agonist using genetically humanized mice. [PDF]

Cell Rep
Mizuno N, Abraham J, Jimenez-Perez K, Rose I, Springgay L, Boehm D, Ando T, Streblow D, Ward J, Miller S, Pandey U, Junaid A, Joyner D, Muir R, Haddad EK, Burkhart D, Rasheed O, DeFilippis VR.   +17 more
europepmc   +1 more source

Glutathione peroxidase 3 preserves hepatocyte mitochondrial quality control to enhance macrophage pro‐regenerative phenotype during liver regeneration

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
(1) GPX3 inhibits VDAC1 oligomerisation by directly binding to it. (2) The loss of GPX3 leads to VDAC1 oligomerisation, resulting in dysregulation of mitochondrial quality control, characterised by enhanced fission, weakened fusion and impaired autophagy.
Yuechen Wang, Jian Xu, Zeyu Zhu, Ye Zhang, Haoran Hu, Yiyun Gao, Yuting Tao, Feifan Yao, Suiqing Zhou, Weizhe Zhong, Zhuqing Rao, Haoming Zhou, Xuehao Wang   +12 more
wiley   +1 more source

Neural Crest-Derived Stem Cell Secretomes and Extracellular Vesicles Disrupt Glioblastoma through Dual-Pathway Inflammatory Rebalancing. [PDF]

Stem Cell Rev Rep
Asadpour A, Ozsoy N, Napier L, Cox K, Needs S, Taylor KA, Brown H, Pivoriūnas A, Stephens P, Dash P, Cottrell GS, Widera D.   +11 more
europepmc   +1 more source

Radiolabeled Coordination Polymer‐Loaded Microneedles for Synergistic Melanoma Brachytherapy–Immunotherapy via STING Activation and Pyroptosis

Exploration, Volume 6, Issue 3, June 2026.
We developed a dissolvable microneedle patch that locally delivers a radiolabeled coordination polymer designed to simultaneously destroy tumor cells and stimulate antitumor immunity through STING activation and pyroptosis. This strategy significantly inhibited melanoma growth and improved the effectiveness of immune checkpoint therapy, highlighting a ...
Pian Yu, Shijun Xiang, Lu Hao, Jessica C. Hsu, Kaixuan Li, Rongxuan Yan, Ming Zhou, Yongxiang Tang, Ying Peng, Weibo Cai, Cong Peng, Peng Liu, Shuo Hu   +12 more
wiley   +1 more source

Porcine hemagglutinating encephalomyelitis virus nucleocapsid protein targets RIG-I and IRF3 to evade IFN immunity. [PDF]

J Virol
Mu S, Bai Y, Qiu R, Zhang F, Shi J, Lan Y, Gao F, He W, Li Z.   +8 more
europepmc   +1 more source

Spleen Tyrosine Kinase (SYK) is Necessary for cGAS‐STING Signaling in Müller Glia and Visual Function Deficits in Diabetic Mice

Glia, Volume 74, Issue 6, June 2026.
Hyperglycemic conditions increased mitochondrial membrane permeability and inflammatory signaling in Müller cells via cGAS‐STING activation. SYK was necessary for cGAS–STING activation and increased cytokine expression in Müller cells. Müller glia‐specific SYK deletion reduced glial activation and attenuated inflammatory cytokine expression in the ...
Esma I. Yerlikaya, Siddharth Sunilkumar, Sandeep M. Subrahmanian, Allyson L. Toro, Clay T. Yeager, Kashif A. Shaikh, Edward W. Harhaj, Alistair J. Barber, Michael D. Dennis   +8 more
wiley   +1 more source

Lactobacillus plantarum extracellular vesicles inhibit avian reovirus replication via activation of the STING-IRF3 signaling pathway. [PDF]

Poult Sci
Qu G, Zhang X, Zhang S, Ji X, Song Y, Shan X, Wang A, Wang Y, Sun Y, Hu J.   +9 more
europepmc   +1 more source

Interferon Regulatory Factor 3 as a Mediator and Therapeutic Target in Innate Immune-Driven Corneal Stromal Inflammation and Opacity. [PDF]

Invest Ophthalmol Vis Sci
Lee SH, Lee SJ, Yun YI, Koh A, Song H, Lee Y, Yoon CH, Kim KH, Kim KW.   +8 more
europepmc   +1 more source