Results 131 to 140 of about 37,349 (239)

Inflammation causes insulin resistance in mice via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels

Nature Communications
Obesity-induced inflammation causes metabolic dysfunction, but the mechanisms remain elusive. Here we show that the innate immune transcription factor interferon regulatory factor (IRF3) adversely affects glucose homeostasis through induction of the ...
Shuai Yan, Anna Santoro, Micah J. Niphakis, Antonio M. Pinto, Christopher L. Jacobs, Rasheed Ahmad, Radu M. Suciu, Bryan R. Fonslow, Rachel A. Herbst-Graham, Nhi Ngo, Cassandra L. Henry, Dylan M. Herbst, Alan Saghatelian, Barbara B. Kahn, Evan D. Rosen   +14 more
doaj   +1 more source

IRF3-p300 axis controls global acetylation and mitotic progression

Accurate mitotic progression depends on precisely regulated post-translational modifications, including lysine acetylation, but the upstream mechanisms governing acetylation during mitosis remain unclear.
Kim, WJ, Lee, JH, Ko, EB, Lim, SB, Basit, A, Shim, J, Heo, Y   +6 more
core   +1 more source

A Pathogen Independent T-cell Intrinsic role for IRF3 [PDF]

, 2018
IRF3 has been recognized as a crucial transcription factor for the activation of innate immune responses. Recent studies have implicated IRF3 in regulating IL17A production of the CD4+ subset, Th17.
Dankar, Amay
core  

A bioinspired catalytic nanoplatform for ferroptosis‐immunotherapy synergy in metastatic cancer

BMEMat, EarlyView.
The bioinspired nanoplatform MnMSN@MnP‐PEG co‐delivers manganese peroxidase and manganese ions to synergistically induce immunogenic ferroptosis and activate the cGAS‐STING pathway, eliciting potent antitumor immunity against primary and metastatic tumors.
Panpan Xue, Hai Cai, Ying Sun, Yaxin Ma, Siyuan Liu, Jinying Zhu, Yan Chen, Xuemei Zeng, Shuangqian Yan   +8 more
wiley   +1 more source

Activation of the cGAS‐STING‐IRF3 Axis by Type I and II Interferons Contributes to Host Defense

Advanced Science
Interferons (IFNs) activate JAK‐STAT pathways to induce downstream effector genes for host defense against invaded pathogens and tumors. Here both type I (β) and II (γ) IFNs are shown that can activate the transcription factor IRF3 in parallel with STAT1.
Zhen Tong, Jia‐Peng Zou, Su‐Yun Wang, Wei‐Wei Luo, Yan‐Yi Wang   +4 more
doaj   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Electrochemical Valence‐Regulated Biomimetic Nanozymes for Breast Cancer Metabolism Inhibition and Potentiated Catalytic Immunotherapy

Exploration, EarlyView.
MnOx nanozymes face low tumoricidal activity and PD‐L1‐mediated immune attenuation. Electrochemically regulated M‐MnOx with high oxidase activity was TCM‐wrapped into TMO. TMO targets tumors, triggers ICD, activates cGAS‐STING, antagonizes PD‐L1, and suppresses tumor recurrence, providing new insights for Mn‐based nanomaterials.
You Pan, Wei Cai, Meng Suo, Xiangqin Meng, Shengxin Ye, Yuping Tan, Xianqing Wei, Mingpu Yang, Pengyuan Qi, Zihang Yu, Kelong Fan, Shipeng Ning   +11 more
wiley   +1 more source

Interferon Regülatör Faktör 3 (Irf3) Geninin Genetik Analizi

, 2014
Interferon Regulating Factor 3 (IRF3) protein is a member of IRF (Interferon Regulating Factors) family. Most of IRFs play an important role in the constitution of responses to pathogens, differentiation hematopoietic cells, regulation of gene expression,
Mosayyebi, Solmaz
core  

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Activation of IRF3 in cardiomyocytes impairs mitochondrial oxidative function through PGC-1α inhibition and drives heart failure

Nature Communications
Heightened sterile inflammation and mitochondrial metabolic dysfunction drives the pathophysiology of heart failure in ischemic cardiomyopathy. Yet, the transcriptional regulators within cardiomyocytes driving crosstalk between inflammation and energy ...
Manju Kumari, Ioannis Evangelakos, Anushka Deshpande, Kirstie A. De Jong, Nesrin Schmiedel, Nicolàs Palacio-Escat, Adriano de Britto Chaves-Filho, Roberto Carlos Frias-Soler, Glynis Klinke, Hyun Cheol Roh, Luisa Lange, Michael Berlin, Marceline M. Fuh, Jakob Johannes Buss, Tian Tian, Carolin Lerchenmüller, Marc Freichel, Almut Schulze, Viacheslav O. Nikolaev, Thomas Eschenhagen, Evan D. Rosen, Ludger Scheja, Ashraf Yusuf Rangrez, Joerg Heeren, Norbert Frey   +24 more
doaj   +1 more source