Results 181 to 190 of about 37,349 (239)

The bidirectional immunoregulatory effects of Traditional Chinese Medicine on the cGAS-STING signaling pathway and their translational prospects. [PDF]

Chin Med
Yang Y, Sun Y, Cheng Y, Pan Z, Zhou J.
europepmc   +1 more source

Targeting the DNA Damage Response in Cancer

MedComm, Volume 7, Issue 10, October 2026.
Targeting the DNA damage response (DDR) reshapes both tumor vulnerability and antitumor immunity. DNA lesions and DDR inhibitors can promote cytosolic nucleic‐acid sensing, antigen presentation, and immune activation, but can also induce adaptive immune escape.
Yihuan Qiao, Boyu Kang, Jian Zhang, Rui Zhang, Jipeng Li   +4 more
wiley   +1 more source

The APC/C subunit APC7 exerts antiviral effects by targeting the adaptor protein MAVS. [PDF]

Front Immunol
Su R, Sun A, Niu Y, Zhao T, Wang H.
europepmc   +1 more source

Bruton's Tyrosine Kinase Inhibitors: Mechanisms, Efficacy, Toxicities and Applications for the Treatment of Human Diseases

MedComm, Volume 7, Issue 10, October 2026.
BTK inhibitors suppress malignant B‐cell signaling while simultaneously reshaping immune regulation through effects on T cells and the tumor microenvironment. These mechanisms support combination immunotherapy strategies and also underlie the expanding application of BTK inhibitors in solid tumors, autoimmune and inflammatory diseases.
Miao Sun, Dengju Li, Jia Wei
wiley   +1 more source

A <i>TBK1</i> mutation disrupting IRF3 activation is associated with familial recurrent myopericarditis. [PDF]

Front Immunol
Peet CJ, Orchard T, Cruz CHB, Hernandez-Cordero A, Omoyinmi E, Mahil SK, Lachmann HJ, Fraternali F, Capon F.   +8 more
europepmc   +1 more source

Alveolar Macrophages: Development, Respiratory Homeostasis, Signal Pathways, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
Alveolar macrophages: development, respiratory homeostasis, signal pathways, diseases, and therapeutic opportunities: During embryonic development, fetal progenitors migrate to the developing lungs via a CX3CR1‐dependent mechanism to establish the TrAM pool.
Sihan Yang, Ruomeng Li, Chuanjiang Yu, Jing Li, Xikun Zhou   +4 more
wiley   +1 more source

The cGAS-STING/MITA pathway in innate antiviral immunity and beyond. [PDF]

Cell Insight
Li FX, Zhong B.
europepmc   +1 more source

Radiotherapy‐Induced Side Effects: Epidemiology, Pathogenesis, Prevention and Treatments

MedComm, Volume 7, Issue 10, October 2026.
Radiotherapy for malignancies frequently injures the organs’ systems through oxidative stress, fibrosis, inflammation, and vascular damage. This review systematically maps the epidemiology, pathogenesis, and emerging therapies to propose a mechanism‑network‑targeted framework for integrated, personalized care in radiation oncology.
Xiaowen Ma, Xiaoxuan Zhang, Pujun Zhao, Jiaxin Yang, Zhihao Li, Xiaoyang Han, Yixuan Wang, Zhenzhen Cui, Nian Liu, Min Li   +9 more
wiley   +1 more source

KMT5a-Mediated IRF3 Stabilization Enhances Macrophage Chemotaxis and Renal Fibrosis Progression. [PDF]

FASEB J
Yang M, Xia P, Liu J, Yang H, Jiang Y, Wei M.   +5 more
europepmc   +1 more source

Prodh2‐Mediated Mitochondrial Stress Drives TNF‐α‐Induced Myoblast Dysfunction and Sarcopenia in COPD

Aging Cell, Volume 25, Issue 10, October 2026.
TNF‐α upregulates Prodh2 via p53 in COPD myoblasts, driving mitochondrial ROS–induced cGAS/STING activation and myoblast dysfunction. This metabolic‐immune pathway underlies sarcopenia, positioning Prodh2 as a therapeutic target for COPD‐associated muscle wasting. ABSTRACT Sarcopenia in chronic obstructive pulmonary disease (COPD) is driven by elevated
Gang Chen, Zhitao Shangguan, Jingjing Gong, Dalu Cheng, Penghong Chen, Jiandong Li, Qiong Lin   +6 more
wiley   +1 more source