Results 51 to 60 of about 3,601 (174)

Phase I-II study of irinotecan hydrochloride combined with cisplatin in patients with advanced gastric cancer. [PDF]

, 1997
PURPOSE A dose-escalation study of irinotecan hydrochloride (CPT-11) combined with fixed-dose cisplatin was conducted to determine the maximum-tolerated dose (MTD), dose-limiting toxicities, and objective response rate in patients with advanced gastric ...
Y Watanabe, S Yoshida, A Ohtsu, T Yokoyama, K Shirao, H Kondo, Y Oda, N Boku, Y Shimada, D Saito, T Fujii, K Muro, H Fukuda, T Yamao, H Ono, M Oka   +15 more
core   +1 more source

Targeting Tumor Stroma: Current Challenges and Future Directions

MedComm, Volume 7, Issue 5, May 2026.
Figure 1. Mechanism of ECM reprogramming. Cancer‐associated fibroblasts (CAFs), cancer‐associated macrophages (CAMs), and other mesenchymal cells alter the ECM composition and increase its stiffness by depositing matrix components such as collagen and hyaluronic acid, and secreting cross‐linking agents like lysyl oxidase homolog 2 (LOXL2).
Siwei Wang, Haofan Hu, Weifeng Zeng, Lu Qin, Xiaoping Chen, Zhibin Liao, Furong Liu, Zhanguo Zhang   +7 more
wiley   +1 more source

PHARMACOKINETICS OF GEMCITABINE HYDROCHLORIDE AND IRINOTECAN HYDROCHLORIDE ALONE AND IN COMBINATION IN RAT PLASMA BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY-DIODE ARRAY DETECTOR [PDF]

, 2018
This communication reports an easy and quick HPLC-PDA method for the simultaneous analysis of Irinotecan Hydrochloride and Gemcitabine Hydrochloride in rat plasma samples both after single drug administration and drugs association.
Christian Celia, Marcello Locatelli, Donatella Paolino, Luisa Di Marzio, Donato Cosco   +4 more
core  

Development and validation meyhod for determination of irinotecan hydrochloride encapsulation into liposomes (short communication) [PDF]

, 2015
Статья посвящена разработке и валидации экспресс-методики определения степени инкапсуляции иринотекана гидрохлорида в липосомы. Валидация проведена по показателям «специфичность», «линейность» и «предел обнаружения».The article is dedicated to creation ...
Стадниченко, А. В., Стадниченко, Александр Викторович, Швец, В. И., Швец, Виталий Иванович, Краснопольский, Юрий Михайлович   +4 more
core  

Temporary loss of consciousness during cetuximab treatment of a patient with metastatic colon cancer: a case report

Surgical Case Reports, 2019
Background Anti-epidermal growth factor receptor (EGFR) antibody is widely used for the treatment of patients with metastatic colorectal cancer. Hypomagnesemia is a comparatively frequent adverse event of this drug, which is likely overlooked because it ...
Taro Fukui, Koichi Suzuki, Sawako Tamaki, Iku Abe, Yuhei Endo, Hideki Ishikawa, Nao Kakizawa, Fumiaki Watanabe, Masaaki Saito, Shingo Tsujinaka, Kazushige Futsuhara, Yasuyuki Miyakura, Hiroshi Noda, Toshiki Rikiyama   +13 more
doaj   +1 more source

Exosomal Non‐Coding RNAs in Gastrointestinal Cancer Drug Resistance: A Systematic Review of Emerging Mechanisms and Clinical Implications

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Gastrointestinal (GI) tumours are one of the most prevalent cancers globally. Even with normal GI function, individuals may develop neoplasms, highlighting the need to better understand the underlying causes of tumorigenesis. The emergence of tumour drug resistance represents the main reason for the failure of drug treatment; thus, it is ...
Mohsen Sharif‐zak, Zahra Sadeghloo, Fateme Binayi, Stefania Nobili, Sara Ashtari, Amir Sadeghi, Nayeralsadat Fatemi   +6 more
wiley   +1 more source

Effect of metformin/irinotecan-loaded poly-lactic-co-glycolic acid nanoparticles on glioblastoma: in vitro and in vivo studies [PDF]

, 2018
Aim: The present study was designed to evaluate the effects of irinotecan hydrochloride (IRI)- or metformin hydrochloride (MET)-loaded poly-lactic-co-glycolic acid (PLGA) nanoparticles (NPs) for the treatment of glioblastoma multiforme using in vitro ...
HACIMÜFTÜOĞLU, Ahmet, Gundogdu, Betül, Taspinar, Mehmet, Taspinar, Numan, Stivaktakis, Polychronis, ÇETİN, Meltem, Abd El-Aty, A. M., Nalci, Kemal Alp, JEONG, Ji Hoon, JUNG, Tae Woo, MEZHUEV, Yaroslav, OKKAY, Ufuk, GALATEANU, Bianca, TAGHIZADEHGHALEHJOUGHI, ALI, Tsatsakis, Aristidis, UĞUR, Afife Büşra, UYANIK, Abdullah, MOHAMMADZADEH, Maryam   +17 more
core   +1 more source

Long‐term results of palliative placement of very low‐axial force self‐expandable metallic stents for malignant colorectal obstruction

DEN Open, Volume 6, Issue 1, April 2026.
Abstract Objectives Stent placement is a standard option for palliative decompression in patients with malignant colorectal obstruction. Long‐term stent placement is associated with perforation, migration, and stent occlusion. Perforation is associated with life expectancy.
Rika Kyo, Takashi Sasaki, Shuntaro Yoshida, Hiroyuki Isayama, Tomonori Yamada, Toshiyuki Enomoto, Yorinobu Sumida, Toshio Kuwai, Masafumi Tomita, Takeaki Matsuzawa, Rintaro Moroi, Toshiyasu Shiratori, Yoshihisa Saida   +12 more
wiley   +1 more source

Voltammetric Behaviour of the Anticancer Drug Irinotecan and its Metabolites in Acetonitrile. Implications for Electrochemical Therapeutic Drug Monitoring [PDF]

, 2018
In this paper the voltammetric behaviour of the anticancer drug irinotecan (CPT-11), its injectable form in the clinical treatment regimen, irinotecan hydrochloride (CPT-11HCl), and its main metabolites (namely SN-38, SN-38G, APC, and NPC), and the ...
Polo, Federico, Daniele, Salvatore, Tartaggia, Stefano, Salvatore Daniele, Gregorio Bonazza, Federico Polo, Bonazza, Gregorio, Stefano Tartaggia, Toffoli, Giuseppe, Giuseppe Toffoli, Stefano, Tartaggia, Giuseppe, Toffoli   +11 more
core   +1 more source

Pharmacokinetics of irinotecan hydrochloride (CPT-11) in a hemodialysis patient

Nihon Toseki Igakkai Zasshi, 2003
塩酸イリノテカン (CPT-11) は, I型DNAトポイソメラーゼ阻害によりDNA合成を阻害し, 広い抗腫瘍スペクトラムを持つ. 血液透析療法中の患者ではCPT-11を減量し使用した報告は一例あるものの, その薬物動態, 透析性についての報告はない. われわれは, 維持血液透析中の大腸癌肝転移例にCPT-11を単回投与し, その薬物動態, 透析性について検討した.症例は58歳, 男性. インフォームドコンセントを得た後, CPT-11 50mg/m2を透析2時間前より90分かけて点滴静注し, 透析開始直後および0.5, 1, 2, 4, 8, 12, 24時間後にCPT-11およびその代謝物質 (SN-38およびSN-38G) の血漿中濃度を測定した.
Iwazu, Yoshitaka, Inoue, Makoto, Yanagiba, Satoru, Miyata, Yukio, Okada, Masaki, Nagai, Hideo, Ando, Yasuhiro, Honma, Sumiko, Asano, Yasushi, Kusano, Eiji   +9 more
openaire   +1 more source