Results 41 to 50 of about 3,601 (174)

Compatibility of Irinotecan Hydrochloride Injection with Other Injections.

Japanese Journal of Hospital Pharmacy, 1996
The compatibility of irinotecan hydrochloride injection (Topotecin® injection) was studied regarding changes in pH following the addition of 0.1N NaOH or 0.1N HC1 solution along with changes in external appearance, pH and contents of both irinotecan and admixed drugs following mixing with 20 kinds of other injections.
TANOUE, NAOMI, UEDA, HITOMI, MORIYAMA, YUHSUKE, ARIMORI, KAZUHIKO, NAKANO, MASAHIRO, KIKUCHI, MASAHIKO, SANO, MIZUO, KATAOKA, KATSUO   +7 more
openaire   +2 more sources

Delivery of nano‐formulated drugs to solid tumours is selectively increased by co‐application of the vascular disrupting agent CA4P

British Journal of Pharmacology, EarlyView.
Background and purpose Nano‐formulated chemotherapeutics prolong systemic availability of drugs and can reduce systemic toxicity, but their accumulation in solid tumours is often limited and unpredictable. Broadly applicable strategies to selectively enhance tumour delivery are lacking.
Annabel Kitowski, Constanze Heise, Stefanie Sperling, Jasmin Hotz, Danica Bajic, Marina Rubey, Kathrin Klar, Georg Höfner, Julien Vollaire, Veronique Josserand, Jean‐Luc Coll, Oliver Thorn‐Seshold, Petar Marinković, Julia Thorn‐Seshold   +13 more
wiley   +1 more source

Irinotecan Hydrochloride Administration Considering Dosing-Time Attenuates Delayed Diarrhea in Rats

Pharmaceutics
Background: Irinotecan hydrochloride (CPT-11) is an important anticancer drug used in a wide range of regimens to treat colorectal and gastric cancers, and one of its severe side effects is delayed diarrhea. Therefore, based on known circadian variations
Hideto To, Mari Tomonari, Makoto Myojin, Fumiyasu Okazaki   +3 more
doaj   +1 more source

Exploring the Potential of Zero‐Dimensional Carbon Nanomaterials in Photoluminescent, Electrochemiluminescent and Electrochemical Sensors

Advanced Materials Interfaces, Volume 13, Issue 11, 9 June 2026.
Zero‐dimensional carbon nanomaterials are presented as multifunctional platforms linking structure, property, and sensing performance. Surface engineering and heteroatom doping modulate electron‐transfer and luminescent behavior, enabling electrochemical, photoluminescent, and electrochemiluminescent detection. Fundamental design principles, analytical
Gustavo Martins, Jeferson Luiz Gogola, Ava Gevaerd, Cristiane Kalinke, Paulo Roberto de Oliveira, Fabio Roberto Caetano, Bruno Campos Janegitz, Márcio Fernando Bergamini, Luiz Humberto Marcolino‐Junior   +8 more
wiley   +1 more source

TLR4-dependent claudin-1 internalization and secretagogue-mediated chloride secretion regulate irinotecan-induced diarrhea [PDF]

, 2016
We have previously shown increased intestinal permeability, to 4-kDa FITC-dextran, in BALB/c mice treated with irinotecan. Importantly, genetic deletion of Toll-like receptor 4 (TLR4; Tlr4-/-) protected against loss of barrier function, indicating that ...
Bowen, Joanne M., Secombe, Kate R., Gibson, Rachel J., Logan, Richard M., Wardill, Hannah R., Ball, Imogen A., Coller, Janet K., Van Sebille, Ysabella Z.A.   +7 more
core   +1 more source

An engineered specificity of Irinotecan loaded Proniosomes: Design and Characterization [PDF]

, 2011
The aim of this investigation was to prepare, characterize and optimize the irinotecan loaded proniosomes for overall improvement in the efficacy, reduced toxicity and enhancement of therapeutic index of irinotecan.
Joshi, Vijay G.; N.E.T Pharmacy College Raichur Karnataka, Goudanavar, Prakash s; N.E.T Pharmacy College Raichur Karnataka   +1 more
core   +2 more sources

Formulation and Systematic Optimisation of Polymeric Blend Nanoparticles via Box–Behnken Design

Pharmaceutics
Background/Objectives: Despite the advantages of polycaprolactone (PCL) for drug delivery, it still lacks effective approaches to enhance its encapsulation of drugs.
Basant Salah Mahmoud, Christopher McConville   +1 more
doaj   +1 more source

Irinotecan hydrochloride for the treatment of recurrent and refractory non‐Hodgkin lymphoma [PDF]

Cancer, 2002
AbstractBACKGROUNDIrinotecan hydrochloride (CPT‐11) has a broad range of antitumor activity and has demonstrated little cross‐resistance with doxorubicin or vincristine. In the current study, the authors investigated the efficacy and adverse effects of irinotecan in the treatment of recurrent and refractory non‐Hodgkin lymphoma, for which current ...
Katsuki, Sugiyama, Ken, Omachi, Keiichi, Fujiwara, Takashi, Saotome, Nobuyuki, Mizunuma, Shunji, Takahashi, Yoshinori, Ito, Keisuke, Aiba, Noboru, Horikoshi   +8 more
openaire   +2 more sources

Alleviating Irinotecan-Induced Diarrhea Using Locally Bioavailable Naturally Occurring Flavonoids [PDF]

, 2023
Chemotherapy-induced diarrhea is a frequent side effect that occurs with several chemotherapeutic agents. However, it is an understudied area in the management of cancer. This concern is significant with irinotecan, a camptothecin derivative.
Etim, Imoh
core   +1 more source

Simultaneous determination of Gemcitabine Hydrochloride and Irinotecan Hydrochloride in rat plasma by high performance liquid chromatography-diode array detector [PDF]

, 2017
This comunication reports a easy and quick HPLC-PDA method for the simultaneous analysis of Irinotecan Hydrochloride and Gemcitabine Hydrochloride in rat plasma samples both after single drug administration and drugs association.
Paolino, Donatella, Cosco, Donato, LOCATELLI, Marcello, CELIA, Christian, DI MARZIO, Luisa   +4 more
core