Results 21 to 30 of about 3,601 (174)

Discovery of Essential Genes as Possible Targets for Prostate Cancer Drug Development [PDF]

International Journal of Genomics
Prostate cancer (PCa) is a major malignancy affecting men and is a significant contributor to global male mortality. Over the past decade, several new treatments for advanced PCa have been approved; however, opportunities remain for the development of ...
Md Amanat Ullah Arman, Md. Selim Reza, Muhammad Habibulla Alamin, Tasnia Akter Maya, Md. Tofazzal Hossain   +4 more
doaj   +2 more sources

Hyaluronan self-agglomerating nanoparticles for non-small cell lung cancer targeting

Cancer Nanotechnology, 2022
Background Owing to the limited amount of research, there are no nanoparticle-based anticancer agents that use hydrophilic drugs. Therefore, we developed irinotecan-loaded self-agglomerating hyaluronan nanoparticles (ISHNs).
Joo-Eun Kim, Young-Joon Park
doaj   +1 more source

PNA-Modified Liposomes Improve the Delivery Efficacy of CAPIRI for the Synergistic Treatment of Colorectal Cancer

Frontiers in Pharmacology, 2022
Tumor-associated antigen mucin 1 (MUC1) is highly expressed in colorectal cancer and is positively correlated with advanced stage at diagnosis and poor patient outcomes.
Wenbin Diao, Wenbin Diao, Ben Yang, Ben Yang, Sipeng Sun, Sipeng Sun, Anping Wang, Anping Wang, Rongguan Kou, Qianyun Ge, Qianyun Ge, Mengqi Shi, Mengqi Shi, Bo Lian, Bo Lian, Tongyi Sun, Tongyi Sun, Jingliang Wu, Jingliang Wu, Jingkun Bai, Jingkun Bai, Meihua Qu, Yubing Wang, Yubing Wang, Wenjing Yu, Wenjing Yu, Zhiqin Gao, Zhiqin Gao   +27 more
doaj   +1 more source

Colon Cancer Pharmacogenetics: A Narrative Review

Pharmacy, 2022
Currently, metastatic colon cancer is treated with monotherapeutic regimens such as folinic acid, fluorouracil, and oxaliplatin (FOLFOX), capecitabine and oxaliplatin (CapeOX), and leucovorin, fluorouracil, and irinotecan hydrochloride (FOLFIRI).
Álvaro Esteban Alfaro Alfaro, Brayan Murillo Castillo, Eugenia Cordero García, Javier Tascón, Ana I. Morales   +4 more
doaj   +1 more source

First human study in treatment of unresectable liver metastases from colorectal cancer with irinotecan-loaded beads (DEBIRI) [PDF]

, 2012
The objective of this pilot clinical study was to assess the safety, technical feasibility, pharmacokinetic (PK) profile and tumour response of DC Bead™ with irinotecan (DEBIRI™) delivered by intra-arterial embolisation for the treatment of metastatic ...
Hammerstingl, Renate Maria, Mack, Martin G., Gallus, Christof, Eichler, Katrin, Gruber-Rouh, Tatjana, Vogl, Thomas J., Zangos, Stephan   +6 more
core   +1 more source

Development of a clinical microarray system for genetic analysis screening

Practical Laboratory Medicine, 2023
Objectives: Research on the relationship between diseases and genes and the advancement of genetic analysis technologies have made genetic testing in medical care possible.
Hiroshi Okamura, Hirofumi Yamano, Toshiya Tsuda, Junichi Morihiro, Koichi Hirayama, Hiroaki Nagano   +5 more
doaj   +1 more source

Phase I study of TP300 in patients with advanced solid tumors with pharmacokinetic, pharmacogenetic and pharmacodynamic analyses [PDF]

, 2012
Background: A Phase I dose escalation first in man study assessed maximum tolerated dose (MTD), dose-limiting toxicity (DLT) and recommended Phase II dose of TP300, a water soluble prodrug of the Topo-1 inhibitor TP3076, and active metabolite, TP3011.
Hartley, J.A., MacPherson, I.R.J., Masanori Miwa, Hartley, JM, Jones, K, Crawford Donna, Saito Tomohisa, Evans, TRJ, Hartley, JA, Jones Keith, MacPherson, IRJ, Abe Masaichi, Crawford, D, Jones, K., D Alan Anthoney, John M Hartley, Saito, T., Twelves, C., Hartley Janet A, Anthoney, D.A., Christopher Twelves, Anthoney, DA, Miwa, M., Miwa Masanori, TRJ Evans, Evans, T.R.J., Naik, J, Jay Naik, Donna Crawford, Keith Jones, Abe, M., Saito, T, Tomohisa Saito, Abe, M, Naik Jay, Naik, J., MacPherson Iain RJ, Evans TRJ, Hartley, J.M., Hartley John M, Masaichi Abe, Miwa, M, Twelves, C, Crawford, D., Anthoney D, Janet A Hartley, Twelves Christopher, Iain RJ MacPherson   +47 more
core   +1 more source

Bioactive fatty acid analog-derived hybrid nanoparticles confer antibody-independent chemo-immunotherapy against carcinoma

Journal of Nanobiotechnology, 2023
Typical chemo-immunotherapy against malignant carcinoma, is characterized by the combined application of chemotherapeutic agents and monoclonal antibodies for immune checkpoint blockade (ICB).
Xi Tan, Chenhui Wang, Hong Zhou, Shuting Zhang, Xuhan Liu, Xiangliang Yang, Wei Liu   +6 more
doaj   +1 more source

New Drugs: Irinotecan hydrochloride [PDF]

Australian Prescriber, 2005
openaire   +2 more sources

Causes of Death Among Patients With Initially Inoperable Pancreas Cancer After Induction Chemotherapy and Ablative 5-fraction Stereotactic Magnetic Resonance Image Guided Adaptive Radiation Therapy

Advances in Radiation Oncology, 2023
Purpose: Nearly all patients with pancreatic ductal adenocarcinoma (PDAC) eventually die of progressive cancer after exhausting treatment options. Although distant metastases (DMs) are a common cause of death, autopsy studies have shown that locoregional
Michael D. Chuong, MD, Roberto Herrera, BS, Antonio Ucar, MD, Santiago Aparo, MD, Fernando De Zarraga, MD, Horacio Asbun, MD, Ramon Jimenez, MD, Domenech Asbun, MD, Govindarajan Narayanan, MD, Sarah Joseph, MD, Rupesh Kotecha, MD, Matthew D. Hall, MD, MBA, Kathryn M. Mittauer, PhD, Diane Alvarez, MSc, James McCulloch, DMP, Tino Romaguera, PhD, Alonso Gutierrez, PhD, MBA, Adeel Kaiser, MD   +17 more
doaj   +1 more source