Results 1 to 10 of about 3,420 (146)

Box–Behnken Design of Experiments of Polycaprolactone Nanoparticles Loaded with Irinotecan Hydrochloride [PDF]

Pharmaceutics, 2023
Background: The Box–Behnken design of experiments (BBD) is a statistical modelling technique that allows the determination of the significant factors in developing nanoparticles (NPs) using a limited number of runs.
Basant Salah Mahmoud, Christopher Mcconville, Mcconville Christopher   +2 more
exaly   +6 more sources

A “Trojan Horse” Strategy: The Preparation of Bile Acid-Modifying Irinotecan Hydrochloride Nanoliposomes for Liver-Targeted Anticancer Drug Delivery System Study [PDF]

Molecules, 2023
The bile acid transport system is a natural physiological cycling process between the liver and the small intestine, occurring approximately 6–15 times during the day.
Li Guo, Yiping Guo, Qiang Ye
exaly   +4 more sources

Evaluation of pharmacological and pharmacokinetic herb-drug interaction between irinotecan hydrochloride injection and Kangai injection in colorectal tumor-bearing mice and healthy rats [PDF]

Frontiers in Pharmacology, 2023
Introduction: Kangai (KA) injection, a Chinese herbal injection, is often used in combination with irinotecan (CPT-11) to enhance the effectiveness of anti-colorectal cancer treatment and alleviate side effects.
Yanfei Chen, Yanfei Chen, Zhaoliang Hu, Jing Jiang, Chenxi Liu, Shuxiao Gao, Min Song, Taijun Hang   +7 more
doaj   +2 more sources

Cost-effectiveness analysis of irinotecan hydrochloride liposome in combination with 5-fluorouracil and leucovorin in locally advanced or metastatic pancreatic ductal adenocarcinoma [PDF]

Frontiers in Pharmacology
ObjectiveThis study aims to evaluate the cost-effectiveness of irinotecan hydrochloride liposome in combination with 5-fluorouracil and leucovorin (5-FU/LV) as a second-line treatment in locally advanced or metastatic pancreatic ductal adenocarcinoma ...
ShaoQing Zhan, PanFeng Feng, PanFeng Feng, PanFeng Feng   +3 more
doaj   +2 more sources

Preparation irinotecan hydrochloride loaded PEGylated liposomes using novel method supercritical fluid and condition optimized by Box–Behnken design [PDF]

Discover Nano
A semi-synthetic camptothecin derivative known as irinotecan hydrochloride is frequently used to treat colorectal cancer, including colorectal adenocarcinoma and lung cancers involving small cells.
Misagh Mohammadi, Mehrnaz Karimi, Farhad Raofie   +2 more
doaj   +2 more sources

Irinotecan Plus Doxorubicin Hydrochloride Liposomes for Relapsed or Refractory Wilms Tumor [PDF]

Frontiers in Oncology, 2021
PurposeThe prognosis of relapsed or refractory pediatric Wilms tumor (WT) is dismal, and new salvage therapies are needed. This study aimed to evaluate the efficacy of the combination of irinotecan and a doxorubicin hydrochloride liposome regimen for ...
Juan Wang, Lian Zhang, Lanying Guo, Yi Que, Yu Zhang, Feifei Sun, Jia Zhu, Suying Lu, Junting Huang, Liuhong Wu, Ruiqing Cai, Zijun Zhen, Sihui Zeng, Yizhuo Zhang, Xiaofei Sun   +14 more
doaj   +3 more sources

Irinotecan hydrochloride liposome HR070803 in combination with 5-fluorouracil and leucovorin in locally advanced or metastatic pancreatic ductal adenocarcinoma following prior gemcitabine-based therapy (PAN-HEROIC-1): a phase 3 trial [PDF]

Signal Transduction and Targeted Therapy
Liposomal irinotecan has shown promising antitumor activity in patients with advanced or metastatic pancreatic ductal adenocarcinoma (PDAC) who have undergone prior gemcitabine-based therapies.
Jiujie Cui, Shukui Qin, Yuhong Zhou, Shuang Zhang, Xiaofeng Sun, Mingjun Zhang, Jiuwei Cui, Weijia Fang, Kangsheng Gu, Zhihua Li, Jufeng Wang, Xiaobing Chen, Jun Yao, Jun Zhou, Gang Wang, Yuxian Bai, Juxiang Xiao, Wensheng Qiu, Bangmao Wang, Tao Xia, Chunyue Wang, Li Kong, Jiajun Yin, Tao Zhang, Xionghu Shen, Deliang Fu, Chuntao Gao, Huan Wang, Quanren Wang, Liwei Wang   +29 more
doaj   +2 more sources

Long-Term Disease-Free Survival After Systemic-First Sequential Multimodal Therapy for Advanced and Recurrent Large-Cell Neuroendocrine Carcinoma of the Uterine Cervix: A Case Report. [PDF]

J Obstet Gynaecol Res
ABSTRACT Cervical large‐cell neuroendocrine carcinoma (LCNEC) is a rare and highly aggressive malignancy with poor prognoses, particularly in advanced or recurrent disease. We describe a case of advanced and recurrent cervical LCNEC in which long‐term disease‐free survival was achieved following a systemic‐first, sequential multimodal treatment ...
Wakana K, Akita M, Tsubata F, Kori Y, Odai T, Miyasaka N.   +5 more
europepmc   +2 more sources

Identifying the Initiation of a New Line of Therapy for Metastatic Lung, Breast, and Colorectal Cancer in Real-World Data: A Scoping Review. [PDF]

Pharmacoepidemiol Drug Saf
ABSTRACT Purpose This study aimed to identify and synthesize published algorithms for identifying the initiation of a new line of therapy (LOT) for metastatic lung, breast, and colorectal cancer in real‐world data (RWD). Methods We conducted a scoping review of published, English‐language studies describing algorithms for identifying any LOTs with ...
Onasanya O, Mahmoudpour SH, Bates B, Shui IM, Liu G, Tan EH, Yang YH, Salas M, Fadare J, Bennett D, Drummond PLM, Shin JJ, Guleria S, Wang JR, Hada M, Denis H, Setoguchi S, Truter I, Lopes LC, Dixon RW.   +19 more
europepmc   +2 more sources

Efficacy and Safety Assessment of 5-Fluorouracil, Irinotecan and Oxaliplatin-Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy. [PDF]

Adv Mater
A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Wade SJ, Kumar AA, Nitschke SO, Joyce P, Minaei E, Reuter SE, Penney C, Warren H, Shepherd R, Dinoro JN, Wallace GG, Dosseto A, Ansar S, Islam N, Lochhead A, Sharbeen G, Phillips PA, Aghmesheh M, Hawthorne WJ, Vine-Perrow KL.   +19 more
europepmc   +2 more sources