Results 11 to 20 of about 3,601 (174)

Role of Glucocorticoid Receptor in the Regulation of Cellular Sensitivity to Irinotecan Hydrochloride [PDF]

Journal of Pharmacological Sciences, 2009
In clinical practice, glucocorticoids are often used with the aim of modulating the efficacy and toxicity of chemotherapeutic agents. However, how glucocorticoids modulate the pharmacological action of chemotherapeutic agents remains to be clarified.
Takanori Akagi, Tatsuo Fukagawa, Yuki Kage, Hideto To, Naoya Matsunaga, Satoru Koyanagi, Akiko Uchida, Asuka Fujii, Hideo Iba, Toshimichi Ikemura, Hironori Aramaki, Shun Higuchi, Shigehiro Ohdo   +12 more
doaj   +5 more sources

Active loading liposomal irinotecan hydrochloride: Preparation, in vitro and in vivo evaluation [PDF]

Asian Journal of Pharmaceutical Sciences, 2013
AbstractThe aim of the present study was to investigate the effect of various transmembrane ammonium salt gradients and different lipid composition on the loading efficiency of liposomal formulations of irinotecan hydrochloride (CPT-11), their behavior in vivo and cytotoxicity.
Hongyan Wei
exaly   +3 more sources

Alleviation of Abdominal Pain due to Irinotecan-Induced Cholinergic Syndrome Using Loperamide: A Case Report [PDF]

Case Reports in Oncology, 2021
Irinotecan hydrochloride (irinotecan) is a chemotherapeutic agent used in the treatment of solid tumors. In addition to severe neutropenia and delayed diarrhea, irinotecan causes cholinergic syndrome, characterized by abdominal pain and acute diarrhea ...
Kazuki Uchiyama, Yoshitaka Saito, Yoh Takekuma, Satoshi Yuki, Mitsuru Sugawara   +4 more
doaj   +2 more sources

Determination of Irinotecan enantiomer impurity in Irinotecan Hydrochloride API by using reverse-phase liquid chromatography [PDF]

Journal of Drug Delivery and Therapeutics, 2023
To evaluate and quantify Irinotecan (R-enantiomer) / Irinotecan related compound D in Irinotecan hydrochloride trihydrate API, a high stereo-specific liquid chromatography technique was developed and validated. The partition was accomplished on ChiralpakIC-3 (150 x 4.6 mm 3µm) through a mobile fragment comprising 0.1 % v/v Formic acid in water and ...
Anjaneyulu Vinukonda, Gana Manjusha K, Vijay Srinivas P   +2 more
openaire   +3 more sources

LAL test and RPT for endotoxin detection of CPT-11/DSPE-mPEG2000 nanoformulation: What if traditional methods are not applicable? [PDF]

Asian Journal of Pharmaceutical Sciences, 2018
Endotoxin detection is an important step in drug characterization. Herein we found that a chemotherapeutic drug nanoformulation composed of irinotecan hydrochloride (CPT-11) and an amphiphilic molecule DSPE-mPEG2000 can interfere with the limulus ...
Yanan Jin, Juanjuan Jia, Chan Li, Jianqi Xue, Jiabei Sun, Kaiyuan Wang, Yaling Gan, Jing Xu, Yaqin Shi, Xingjie Liang   +9 more
doaj   +2 more sources

Development and Optimization of Irinotecan-Loaded PCL Nanoparticles and Their Cytotoxicity against Primary High-Grade Glioma Cells [PDF]

Pharmaceutics, 2021
Background: High-grade gliomas (HGGs) are highly malignant tumors with a poor survival rate. The inability of free drugs to cross the blood–brain barrier and their off-target accumulation result in dose-limiting side effects.
Basant Salah Mahmoud, Christopher McConville   +1 more
doaj   +3 more sources

In-Silico discovery of Pediatric Acute-Myeloid-Leukemia (pAML) causing druggable molecular signatures highlighting their pathogenetic processes and therapeutic agents through single-cell RNA-Seq profile analysis. [PDF]

PLoS ONE
Pediatric acute-myeloid-leukemia (pAML) is an aggressive malignancy and the second most common blood cancer in children. In spite of significant advances in the frontline therapeutic approaches, approximately 50% of pAML patients show poor prognosis and ...
Md Foysal Ahmed, Md Al Noman, Md Feroj Ahmed, Md Abdul Latif, Md Al Amin Pappu, Md Shariful Islam, Md Sanoar Hossain, Md Bayazid Hossen, Md Fahim Faysal, Md Mehedi Hasan, Md Nurul Haque Mollah   +10 more
doaj   +2 more sources

Evaluation of the Synthesis and Skin Penetration Pathway of Folate-Conjugated Polymeric Micelles for the Dermal Delivery of Irinotecan and Alpha-Mangostin [PDF]

Pharmaceutics
Background/Objectives: The present study aimed to synthesize folate-conjugated poloxamers and develop polymeric micelles for the dermal delivery of irinotecan and alpha-mangostin for the treatment of melanoma using poloxamer 188 and poloxamer 184, which ...
Thanchanok Sirirak, Thirapit Subongkot
doaj   +2 more sources

Real-World Data of Second-Line Amrubicin Monotherapy in Patients With Extensive-Stage Small Cell Lung Cancer Who Received First-Line Chemoimmunotherapy or Chemotherapy: A Multicenter Retrospective Study. [PDF]

Cancer Med
ABSTRACT Background Chemoimmunotherapy is widely used as the first‐line treatment for extensive‐stage small cell lung cancer (ES‐SCLC), but treatment options for second‐line have not changed. Amrubicin monotherapy is used as the standard treatment for relapsed SCLC, but since chemoimmunotherapy became an additional indication for ES‐SCLC, the efficacy ...
Sonehara K, Tsutsui T, Nozawa S, Agatsuma T, Yamamoto M, Matsuo A, Nakanishi M, Chiaki T, Kato A, Miyahara T, Hachiya T, Kanda S, Hirabayashi T, Yanagisawa K, Araki T, Tateishi K, Hanaoka M.   +16 more
europepmc   +2 more sources

Cyclic Peptide-Polymer Conjugate Nanotubes for Delivery of SN-38 in Treatment of Colorectal Cancer Model. [PDF]

Adv Healthc Mater
This study develops cyclic peptidepolymer conjugate nanotubes with hydrophobic, drug‐rich cores to enhance drug loading and stability, and demonstrates their responsive disassembly, pharmacokinetics, and anti‐tumour efficacy in colorectal cancer models using the anticancer drug SN‐38.
Hill SK, Zeng M, Rajendrakumar SK, Dallmann R, Perrier S.   +4 more
europepmc   +2 more sources