Results 31 to 40 of about 3,601 (174)
Journal of Nanobiotechnology, 2022 Background 7-p-trifluoromethylphenyl-FL118 (FLQY2) is a camptothecin analog with excellent antitumor efficacy against various solid tumors. However, its poor solubility and low bioavailability limited the development of the drug.
Yi Wang +6 more
doaj +1 more source
Development and Targeting Efficiency of Irinotecan Engineered Proniosomes [PDF]
, 2012 Purpose: This study is aimed at achieving improvement in the efficacy, reduced toxicity and enhancement of therapeutic index of irinotecan. Methods: Proniosomes of irinotecan hydrochloride trihydrate were prepared by slurry method using different ...
Joshi, Vijay G, Goudanavar, Prakash S
core +5 more sources
Self-Monitoring and Self-Delivery of Self-Assembled Fluorescent Nanoparticles in Cancer Therapy
International Journal of Nanomedicine, 2021 Hongmei Liu,1,2 Minghao Yuan,1,2 Yushi Liu,1,2 Yiping Guo,3 Haijun Xiao,4 Li Guo,1,2 Fei Liu1,2 1School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, People’s Republic of China; 2State Key Laboratory of ...
Liu H +6 more
doaj
Problems on the approval of irinotecan hydrochloride. [PDF]
Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics, 1997 ROKURO HAMA
openaire +3 more sources
RP-HPLC method development and validation for the simultaneous estimation of Irinotecan hydrochloride and Capecitabine in Active Pharmaceutical Ingredients (APIs) [PDF]
, 2018 The combination of Irinotecan Hydrochloride (IRI) and Capecitabine (CAP) is indicated for the treatment of cancer. IRI and CAP were developed by an simultaneous simple reverse phase liquid chromatographic method and were subsequently validated from their
Varalakshmi Devi K +3 more
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Pegylated Liposomal Irinotecan Hydrochloride Trihydrate for Treating Pancreatic Cancer After Gemcitabine: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. [PDF]
, 2017 The National Institute for Health and Care Excellence (NICE) invited the manufacturer (Shire Pharmaceuticals) of pegylated liposomal irinotecan hydrochloride trihydrate (liposomal irinotecan) to submit clinical and cost-effectiveness evidence for its use
Beale, S +19 more
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A rapid and sensitive HPLC method for simultaneous determination of irinotecan hydrochloride and curcumin in co-delivered polymeric nanoparticles [PDF]
, 2020 In recent years, a great deal of attention has been paid to the combined use of multiple antitumor drugs for better cancer treatment. The aims of the study are to construct a nanoparticle drug delivery system for the co-delivery of irinotecan ...
Sedlařík, Vladimír, Xiao, Haijun
core
Journal of Pharmacological Sciences, 2007 The effectiveness and toxicity of antitumor drugs vary depending on dosing time associated with the 24-h rhythms of biochemical, physiological, and behavioral processes under the control of the circadian clock.
Shigehiro Ohdo
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Advanced NanoBiomed Research, EarlyView.Redox responsive mesoporous silica nanoparticles (MSNs) were engineered to deliver gemcitabine (Gem) and cisplatin (cisPt) at defined ratios to overcome chemoresistance in pancreatic ductal adenocarcinoma (PDAC). Optimized Gem MSNs and Gem cisPt MSNs enhanced cytotoxicity in murine and human Gem resistant models, with select formulations inducing ...
Tamanna Binte Huq +5 more
wiley +1 more source