Results 151 to 160 of about 19,243 (300)

The Role of Adipokines in Spinal Disease: A Narrative Review

JOR SPINE, Volume 8, Issue 2, June 2025.
Adipokines, bioactive molecules secreted by adipose tissue, play a key role in both physiological regulation and disease pathogenesis. While their involvement in various organ systems is well documented, their role in spinal pathology remains underexplored.
Jake M. McDonnell, Stacey Darwish, Joseph S. Butler, Conor T. Buckley   +3 more
wiley   +1 more source

Rejuvenation of Senescent Cells, In Vitro and In Vivo, by Low‐Frequency Ultrasound

Aging Cell, Volume 24, Issue 6, June 2025.
Optimized low‐frequency ultrasound rejuvenates induced senescent cells and aged mice. Our results show that LFU reverses 15 aspects of senescent cells including growth and revitalizes aged mice. ABSTRACT The presence of senescent cells causes age‐related pathologies since their removal by genetic or pharmacological means, as well as possibly by ...
Sanjay K. Kureel, Rosario Maroto, Maisha Aniqua, Simon Powell, Ekta Singh, Felix Margadant, Brandon Blair, Blake B. Rasmussen, Michael P. Sheetz   +8 more
wiley   +1 more source

Effects of the VIVIFRAIL Exercise Protocol on Circulatory and Intracellular Peripheral Mediators Bridging Mitochondrial Dynamics and Inflammation in Robust and Frail Older People

Aging Cell, Volume 24, Issue 6, June 2025.
Physical activity promotes functional improvements in both robust and physically frail older adults, driven by distinct adaptation mechanisms in the mitochondria‐inflammation axis that are influenced by age and frailty status. ABSTRACT Physical exercise has been associated with healthier aging trajectories, potentially preventing or mitigating age ...
Fiona Limanaqi, Evelyn Ferri, Pasquale Ogno, Franca Rosa Guerini, Gabriela Alexandra Mihali, Tiziano Lucchi, Mario Clerici, Chiara Fenoglio, Laura D'Andrea, Elena Marcello, Mara Biasin, Beatrice Arosio   +11 more
wiley   +1 more source

Expression, purification and biological characterisation of recombinant human irisin (12.5 kDa)

Journal of Genetic Engineering and Biotechnology, 2018
Fibronectin type III domain containing 5 (FNDC5) is a transmembrane protein. Upon cleavage, it yields a peptide called irisin that is supposedly bind to an unknown receptor and facilitates browning of white adipose tissue (WAT).
Kalpana Panati, Venkata Ramireddy Narala, Vydyanath R. Narasimha, Madhavi Derangula, Venkat R.R. Arva Tatireddigari, Suneetha Yeguvapalli   +5 more
doaj  

Irisin inhibits microglial senescence via TFAM-mediated mitochondrial metabolism in a mouse model of tauopathy

Immunity & Ageing
Background The accumulation of senescent microglia has been highlighted as a critical contributor to the progression of tauopathies. Irisin, a muscle-derived hormone produced by the proteolytic cleavage of Fibronectin-domain III containing 5 (FNDC5 ...
Cailin Wang, Xiufeng Wang, Shangqi Sun, Yanmin Chang, Piaopiao Lian, Hongxiu Guo, Siyi Zheng, Rong Ma, Gang Li   +8 more
doaj   +1 more source

Irisina y envejecimiento [PDF]

, 2018
El envejecimiento es un proceso natural complejo que aborda un amplio espectro de cambios físicos y fisiológicos, y que puede conllevar la aparición dediferentes enfermedades relacionadas.
Carrasco Blanco, Alberto
core  

Interplay between oxidative stress and inflammation in cardiometabolic syndrome [PDF]

, 2016
EditorialAbstract not availableAaron L. Sverdlov, Gemma A. Figtree, John D. Horowitz and Doan T.
Figtree, G., Horowitz, J., Ngo, D., Sverdlov, A.   +3 more
core   +4 more sources

Irisin reduces senile osteoporosis by inducing osteocyte mitophagy through Ampk activation

iScience
Summary: Irisin, an exercise-induced myokine, is known to be able to regulate bone metabolism. However, the underlying mechanisms regarding the effects of irisin on senile osteoporosis have not been fully elucidated. Here, we demonstrated that irisin can
Honghan Li, Deqing Luo, Wei Xie, Wenbin Ye, Jinlong Chen, Paolo Alberton, Mingzhu Zhang, Eryou Feng, Denitsa Docheva, Dasheng Lin   +9 more
doaj  

Dose-dependent tandem responses of osteoblasts during osteogenesis

Medicine in Novel Technology and Devices, 2023
Irisin, a myokine mainly secreted from contracted skeleton muscle, plays a profound role in bone formation and remodeling. Although irisin has been revealed to elevate bone mass in vivo, details whether there is a dose-dependent relationship between ...
Yuwei Zhang, Lizhen Wang, Hongyan Kang, Chia-Ying Lin, Yubo Fan   +4 more
doaj  

Irisin Attenuates Hepatic Stellate Cell Activation and Liver Fibrosis in Bile Duct Ligation Mice Model and Improves Mitochondrial Dysfunction [PDF]

Endocrinology and Metabolism
Background Liver fibrosis is a common outcome of chronic liver disease and is primarily driven by hepatic stellate cell (HSC) activation. Irisin, a myokine released during physical exercise, is beneficial for metabolic disorders and mitochondrial ...
Thuy Linh Lai, So Young Park, Giang Nguyen, Phuc Thi Minh Pham, Seon Mee Kang, Jeana Hong, Jae-Ho Lee, Seung-Soon Im, Dae-Hee Choi, Eun-Hee Cho   +9 more
doaj   +1 more source