Results 81 to 90 of about 6,991 (174)

Irisin Prevents Disuse-Induced Osteocyte Apoptosis

Journal of Bone and Mineral Research, 2019
ABSTRACT Previous results showed that intermittently administered irisin improves bone mass in normal mice and prevents the development of disuse-induced osteoporosis and muscular atrophy in hindlimb-suspended mice, a murine model able to mimic the absence of mechanical loading.
Giuseppina Storlino, Graziana Colaianni, Lorenzo Sanesi, Luciana Lippo, Giacomina Brunetti, Mariella Errede, Silvia Colucci, Giovanni Passeri, Maria Grano   +8 more
openaire   +3 more sources

Integrative physiology of skeletal muscle for maintaining cognitive health

The Journal of Physiology, Volume 604, Issue 6, Page 2448-2457, 15 March 2026.
Abstract figure legend Maintenance of brain/cognitive health and function is increasingly appreciated to be a systemic challenge. In particular, skeletal muscle influences the brain through release of myokines in response to contraction, which influence the expression of brain‐derived neurotrophic factor (BDNF) in the brain, a vital player in the ...
Matthew H. Brisendine, Joshua C. Drake
wiley   +1 more source

The central benefit of physiologically induced ketogenic states

The Journal of Physiology, Volume 604, Issue 6, Page 2430-2447, 15 March 2026.
Abstract figure legend This review describes the association between ketogenic states induced by physiological interventions such as fasting or aerobic exercise, exogenous ketone supply and ketogenic diets, as well as increased cognition through increased activity of brain‐derived neurotrophic factor (BDNF).
Antonia Giacco, Giuseppe Petito, Rosalba Senese, Maria Moreno, Assunta Lombardi, Antonia Lanni, Pieter de Lange   +6 more
wiley   +1 more source

Expressions of irisin and urotensin II and their relationships with blood pressure in patients with preeclampsia

Clinical and Experimental Hypertension, 2017
The aims of this study are to observe irisin and urotensin II (UII) levels in serum and placenta in normal pregnant and preeclamptic women and investigate the relationship between expressions irisin and UII, and their association with blood pressure.
Li-Jie Zhang, Qian Xie, Chao-Shu Tang, Ai-Hua Zhang   +3 more
doaj   +1 more source

Enviromimetics: From exercise mimetics to cognitomimetics in the quest for enhanced brain health and cognition

The Journal of Physiology, Volume 604, Issue 6, Page 2458-2472, 15 March 2026.
Abstract figure legend A schematic diagram outlining the concept of enviromimetics, and the subclasses of exercise mimetics, epimimetics and cognitomimetics. The rationale is that environmental stimulation and lifestyle factors, including physical activity and cognitive stimulation, have shown beneficial effects across a range of human conditions ...
Anthony J. Hannan
wiley   +1 more source

Irisin in Reproduction: Its Roles and Therapeutic Potential in Male and Female Fertility Disorders

Biomolecules
The current study focused on identifying the potential of irisin in mammalian reproduction. The established role of irisin, a proteolytic product of FNDC5, in adipose tissue browning, energy metabolism, and thermogenesis suggests its role in reproductive
Muhammad Ibrahim Khan, Muhammad Imran Khan, Fazal Wahab   +2 more
doaj   +1 more source

Early sensorimotor restriction in rats induces age‐dependent mitochondrial alterations in skeletal muscles and brain structures

The Journal of Physiology, Volume 604, Issue 6, Page 2512-2524, 15 March 2026.
Abstract figure legend This study aimed to determine whether early sensorimotor restriction (SMR) alters mitochondrial enzyme activities in rat muscles and brain structures. SMR was induced via immobilizing the hind limbs of pups for 16 h per day during the dark phase from birth to postnatal day (PND) 28.
Mélanie Van Gaever, Olivier Dupuy, Erwan Dupont, Marie‐Hélène Canu, Frederic Daussin   +4 more
wiley   +1 more source

Different types of exercise and myocardial angiogenesis regulation: A scoping review of cardiac‐specific evidence in animal models

Physiological Reports, Volume 14, Issue 5, March 2026.
Abstract Exercise promotes myocardial angiogenesis, yet molecular responses vary by modality, and cardiac‐specific evidence in healthy models remains fragmented. This study aimed to map biomolecular regulators of myocardial/coronary angiogenesis across exercise types in healthy animal models. PRISMA‐ScR scoping review.
Putri Karisa, Nova Sylviana, Aziiz Mardanarian Rosdianto, Hanna Goenawan, Mas Rizky Anggun Adipurna Syamsunarno, Setiawan   +5 more
wiley   +1 more source

Aging‐Driven Inter‐Organ Crosstalk in Postmenopausal Osteoporosis: From Immunometabolic Drift to Multisystem Frailty

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
Postmenopausal osteoporosis (PMOP) is increasingly recognized as an aging‐associated, multisystem state of fragility, in which estrogen deficiency exacerbates immune and metabolic drift across the bone marrow, skeletal muscle, adipose tissue, gut, vascular system, and neural circuits.
Xianlin Rao, Xiaoyu Cai
wiley   +1 more source

Evolutionary Insights into Irisin/FNDC5: Roles in Aging and Disease from Drosophila to Mammals

Biomolecules
The Irisin/FNDC5 protein family has emerged as a pivotal link between exercise and the prevention of age-associated diseases. Irisin is highly expressed during exercise from skeletal and cardiac muscle cells, playing a critical role in mediating systemic
Kiwon Lee, Myungjin Kim
doaj   +1 more source