Results 71 to 80 of about 83,013 (204)

Oxidative protein biogenesis and redox regulation in the mitochondrial intermembrane space [PDF]

open access: yes, 2016
Mitochondria are organelles that play a central role in cellular metabolism, as they are responsible for processes such as iron/sulfur cluster biogenesis, respiration and apoptosis.
MacPherson, Lisa   +2 more
core   +1 more source

Competing pathways control host resistance to virus via tRNA modification and programmed ribosomal frameshifting

open access: yesMolecular Systems Biology, 2012
Viral infection depends on a complex interplay between host and viral factors. Here, we link host susceptibility to viral infection to a network encompassing sulfur metabolism, tRNA modification, competitive binding, and programmed ribosomal ...
Nathaniel D Maynard   +3 more
doaj   +1 more source

Biosynthesis of Sulfur-Containing tRNA Modifications: A Comparison of Bacterial, Archaeal, and Eukaryotic Pathways

open access: yesBiomolecules, 2017
Post-translational tRNA modifications have very broad diversity and are present in all domains of life. They are important for proper tRNA functions.
Mirela Čavužić, Yuchen Liu
doaj   +1 more source

Human Frataxin Folds Via an Intermediate State. Role of the C-Terminal Region [PDF]

open access: yes, 2016
The aim of this study is to investigate the folding reaction of human frataxin, whose deficiency causes the neurodegenerative disease Friedreich’s Ataxia (FRDA).
Faraj, Santiago Enrique   +3 more
core   +1 more source

The CRISPR associated protein Cas4 Is a 5' to 3' DNA exonuclease with an iron-sulfur cluster.

open access: yesPLoS ONE, 2012
The Cas4 protein is one of the core CRISPR-associated (Cas) proteins implicated in the prokaryotic CRISPR system for antiviral defence. Cas4 is thought to play a role in the capture of new viral DNA sequences for incorporation into the host genome.
Jing Zhang   +2 more
doaj   +1 more source

Complete genome sequence of Syntrophobacter fumaroxidans strain (MPOB(T)). [PDF]

open access: yes, 2012
Syntrophobacter fumaroxidans strain MPOB(T) is the best-studied species of the genus Syntrophobacter. The species is of interest because of its anaerobic syntrophic lifestyle, its involvement in the conversion of propionate to acetate, H2 and CO2 during ...
Crable, Bryan R   +15 more
core   +2 more sources

Mechanism and structural dynamics of sulfur transfer during de novo [2Fe-2S] cluster assembly on ISCU2

open access: yesNature Communications
Maturation of iron-sulfur proteins in eukaryotes is initiated in mitochondria by the core iron-sulfur cluster assembly (ISC) complex, consisting of the cysteine desulfurase sub-complex NFS1-ISD11-ACP1, the scaffold protein ISCU2, the electron donor ...
Vinzent Schulz   +10 more
doaj   +1 more source

Mitochondrial Iron-Sulfur Cluster Dysfunction In Neurodegenerative Disease

open access: yesFrontiers in Pharmacology, 2014
Growing evidence supports a role for mitochondrial iron metabolism in the pathophysiology of neurodegenerative disorders such as Friedreich ataxia and Parkinson disease as well as in the motor and cognitive decline associated with the aging process. Iron-
Grazia eIsaya
doaj   +1 more source

Microarray-based screening of differentially expressed genes of E. coli O157:H7 Sakai during preharvest survival on butterhead lettuce [PDF]

open access: yes, 2016
Numerous outbreaks of Escherichia coli O157:H7 have been linked to the consumption of leafy vegetables. However, up to the present, little has been known about E.
Cottyn, Bart   +6 more
core   +3 more sources

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