Results 61 to 70 of about 214,451 (303)

Iron and Manganese in the Ocean: Investigation of Atmospheric Input by Dust and Coastal Ocean Time Series [PDF]

, 2008
Trace metals such as iron (Fe) and manganese (Mn) are essential micronutrients in the biogeochemistry of the ocean (Turner and Hunter, 2001), and dry deposition is a substantial source of both Fe and Mn to the surface ocean (Duce and Tindale, 1991; Guieu
Mendez, Jeffrey Michael
core   +1 more source

Sex-Related Microglial Perturbation Is Related to Mitochondrial Changes in a Model of Alzheimer’s Disease

Frontiers in Cellular Neuroscience, 2022
Many studies implicate microglia in the pathogenesis of Alzheimer’s disease (AD) but precisely how these cells make their impact has not been determined to date.
Eoin O’Neill, Virginia Mela, Aline Sayd Gaban, Sibylle Bechet, Aoife McGrath, Aife Walsh, Allison McIntosh, Marina A. Lynch   +7 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Iron, copper, zinc, magnesium, and calcium in postmortem brain tissue from schizophrenic patients

, 1994
The regional distribution of iron, copper, zinc, magnesium, and calcium in postmortem brain of schizophrenic patients was compared with that of matched controls.
Kruzik, P., Rausch, W. D., Kornhuber, J., Riederer, P., Lange, Klaus W., Gabriel, E., Jellinger, K.   +6 more
core   +1 more source

Identification of a neuron-specific ferroptosis in the neurodegenerative mucopolysaccharidosis III model

Frontiers in Molecular Biosciences
Sanfilippo syndrome (MPSIII) is a neurodegenerative disorder caused by enzyme deficiencies, leading to the toxic accumulation of heparan sulfate oligosaccharides in the brain.
Mathilde Larribau, Myriam Rouahi, Christophe Santiago, Jérôme Ausseil, Jérôme Ausseil, Zoubida Karim   +5 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

The Relationship Between Iron Accumulation, Vitamin D Deficiency and Bone Mineral Density in Patients with Thalassemia Major, Thalassemia Intermedia and Sickle Cell

Türk Osteoporoz Dergisi, 2020
Objective:Osteopenia and osteoporosis are important causes of morbidity in patients with hemoglobinopathies. This study investigates the association between iron accumulation, vitamin D and bone mineral density (BMD) in patients with thalassemia major ...
Mahmut Büyükşimşek, İsmail Fikri Başlamışlı   +1 more
doaj   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source