Results 41 to 50 of about 214,451 (303)

Insights into molecular mechanisms of disease in Neurodegeneration with Brain Iron Accumulation; unifying theories.

, 2016
Neurodegeneration with brain iron accumulation (NBIA) is a group of disorders characterised by dystonia, parkinsonism and spasticity. Iron accumulates in the basal ganglia and may be accompanied by Lewy bodies, axonal swellings and hyperphosphorylated ...
Arber, C, Houlden, H, H. Houlden, C. E. Arber, S. Wray, Wray, S, A. Li, Li, A   +7 more
core   +1 more source

Neurodegeneration with brain iron accumulation

, 2018
Neurodegeneration with brain iron accumulation (NBIA) describes a heterogeneous group of inherited rare clinical and genetic entities. Clinical core symptoms comprise a combination of early-onset dystonia, pyramidal and extrapyramidal signs with ataxia, cognitive decline, behavioral abnormalities, and retinal and axonal neuropathy variably accompanying
Sarah, Wiethoff, Henry, Houlden
openaire   +5 more sources

Diagnosing neurodegeneration with brain iron accumulation before iron starts to accumulate.

Journal of the International Child Neurology Association, 2019
Introduction Neurodegeneration with brain iron accumulation (NBIA) consists of a heterogeneous group of disorders with brain iron accumulation as common radiological endpoint. Mutations in multiple genes have been associated with NBIA. We present 2 cases with a different type of NBIA, in whom the diagnosis was confirmed before brain iron accumulation ...
Hoogwijs, Ine, Stouffs, Katrien, Seneca, Sara, Gheldof, Alexander, Keymolen, K., De Rademaeker, Marjan, De Meirleir, Linda, Jansen, Anna   +7 more
openaire   +4 more sources

Expression of iron homeostasis proteins in the spinal cord in experimental autoimmune encephalomyelitis and their implications for iron accumulation

Neurobiology of Disease, 2015
Iron accumulation occurs in the CNS in multiple sclerosis (MS) and in experimental autoimmune encephalomyelitis (EAE). However, the mechanisms underlying such iron accumulation are not fully understood. We studied the expression and cellular localization
Juan G. Zarruk, Jennifer L. Berard, Rosmarini Passos dos Santos, Antje Kroner, Jaekwon Lee, Paolo Arosio, Samuel David   +6 more
doaj   +1 more source

Biophysical and Cell Biological Studies Characterizing the Vertebrate Iron Exporter Ferroportin [PDF]

, 2009
Mammalian iron homeostasis is maintained by an intricate network of diverse proteins that constantly survey systemic iron levels and carefully regulate the uptake of iron from the diet. Control of this uptake is critically important because once iron is
Rice, Adrian Edward
core   +1 more source

Phase value assessment reveals iron accumulation in parkinson disease

Medicine Science, 2020
PD is characterized by iron accumulation in the substantia nigra (SN) different from healthy controls. We aim to quantify iron accumulation via susceptibility weighted imaging (SWI) in Parkinson disease (PD).
Ayse Nur Sirin Ozcan, Ebru Bilge Dirik
doaj   +1 more source

Iron Chelation Reduces Intracellular Hydroxyl Radicals in Normal Human Dermal Fibroblasts Independently of Aging

Antioxidants
In cultured skin cells, decreases in antioxidant function and increases in intracellular free Fe2+ due to replicative aging have been reported. The Fenton reaction between Fe2+ and hydrogen peroxide is a threat to the skin because it produces hydroxyl ...
Kazunori Takemoto, Ami Ozaki, Yusuke Tanii, Masayuki Yagi, Masamitsu Ichihashi, Hideya Ando   +5 more
doaj   +1 more source

Parkinson’s Disease: The Mitochondria-Iron Link

Parkinson's Disease, 2016
Mitochondrial dysfunction, iron accumulation, and oxidative damage are conditions often found in damaged brain areas of Parkinson’s disease. We propose that a causal link exists between these three events.
Yorka Muñoz, Carlos M. Carrasco, Joaquín D. Campos, Pabla Aguirre, Marco T. Núñez   +4 more
doaj   +1 more source

Excessive iron accumulation induces beta cell cellular oxidative stress and insulin secretory dysfunction in MIN6 cells

, 2019
Aims: Exposure to high levels of glucose and iron have been co‐related to reactive oxygen species (ROS) generation and oxidative stress in beta cell.
Patel, V., Zariwala, M., Blesia, V., Al‐Obaidi, H.   +3 more
core   +1 more source

Inhibition of SLC40A1 represses osteoblast formation via inducing iron accumulation and activating the PERK/ATF4/CHOP pathway mediated oxidative stress

Redox Report
Objective This study aimed to investigate the effects of solute carrier family 40 member 1 (SLC40A1) on iron accumulation, oxidative stress and differentiation in osteoblasts and potential mechanisms.Methods Mouse preosteoblastic MC3T3-E1 cells were ...
Yu Fang, Wei Li, Chongyang Dong, Binli Gao, Wen Guo, Mingyu Li, Zhichao Jiao   +6 more
doaj   +1 more source