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Iron chelators as therapeutic iron depletion agents
Expert Opinion on Therapeutic Patents, 2006The great promise of iron depletion as a therapeutic strategy for various diseases, including iron overload, cancers, Alzheimer’s disease, Parkinson’s disease, tuberculosis, HIV, and fungal and malaria infection, has stimulated research on the development of iron chelators as iron depletion agents.
Noah Birch, Xiang Wang, Hyun-Soon Chong
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Iron mobilization from ferritin by chelating agents
Journal of Inorganic Biochemistry, 1980The release of iron from horse spleen ferritin by the chelating agents desferrioxamine B, rhodotorulic acid, 2,3-dihydroxybenzoate, 2,2'-bipyridyl and pyridine-2-aldehyde-2-pyridyl hydrazone (Paphy) has been studied in vitro. Ferritin prepared by classical procedures involving thermal denaturation releases its iron less effectively than ferritin ...
R R, Crichton, F, Roman, F, Roland
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Iron mobilization from transferrin by therapeutic iron chelating agents
Biochimica et Biophysica Acta (BBA) - General Subjects, 2012The bacteriostatic activity of the transferrin family has been known since the early 1960's. The possession of high affinity iron(III)-binding sites and the existence of a specific membrane-bound receptor, have led to the present understanding of serum transferrin acting as the major iron transporter between cells in vertebrate systems.
Evans, Robert W. +2 more
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Iron chelating agents for the treatment of iron overload
Coordination Chemistry Reviews, 2008The importance of iron chelators in medicine has significantly increased in recent years. Iron is essential for life but it is also potentially more toxic than other trace elements. This is because we lack effective means to protect human cells against iron overload and because of the role of iron in the generation of free radicals. In order to protect
G. CRISPONI, REMELLI, Maurizio
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Iron chelating agents with clinical potential
Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences, 1992Synopsis:Iron is a critically important metal for a wide variety of cellular events. The element holds this central position by virtue of its facile redox chemistry and the high affinity of both redox states (iron II and iron III) for oxygen. These same properties also render iron toxic when levels exceed the normal binding capacity of the cell.
R. C. Hider, S. Singh, J. B. Porter
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Two novel polymorphic forms of iron-chelating agent deferiprone
Acta Crystallographica Section C Structural Chemistry, 2020Thalassemia is a genetic blood disorder requiring life-long blood transfusions. This process often results in iron overload and can be treated by an iron-chelating agent, like deferiprone (3-hydroxy-1,2-dimethylpyridin-4-one), C7H9NO2, in an oral formulation. The first crystal structure of deferiprone, (Ia), was reported in 1988 [Nelson et al.
Satyasree, Rajendrakumar +3 more
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Iron chelating agents in clinical practice
Coordination Chemistry Reviews, 1999Abstract The relevance of iron chelators in medicine has increased in recent years. Iron is essential for life but it is also potentially more toxic than other trace elements. This is due to the lack of effective means to protect human cells against iron overload and to the role of iron in the generation of free radicals. To protect patients from the
CRISPONI, GUIDO, FAA, GAVINO
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Antioxidant and Iron-chelating Agents in Cerebral Vasospasm
Neurosurgery, 1995Prior work in our laboratory showed that the perivascular application of deferoxamine (an antioxidant and iron-chelating agent) inhibited delayed arterial narrowing after chronic blood exposure in a rat femoral artery model of vasospasm. To determine which of these mechanisms was operant in vasospasm, we compared deferoxamine with two agents (ascorbic ...
Z, Luo +4 more
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Glycosyl‐Curcuminoids as Potential New Chelating Agents in Iron Overload Chelation Therapy
European Journal of Inorganic Chemistry, 2004AbstractThe iron(III) chelating ability of some glycosyl derivatives of curcuminoids is tested by means of UV, potentiometric and NMR studies. The pKa of the ligands and the stability constants of their Fe3+ and Ga3+ complexes are evaluated by UV spectroscopy. The only metal binding site of the ligand is the β‐dioxo moiety; the glycosyl moiety does not
B. Arezzini +5 more
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Iron-chelating agents and the reductive removal of iron from transferrin
Biochemical Pharmacology, 1980Abstract 2-Formylpyridine thiosemicarbazone, a strong iron (II) and iron(III)-chelating agent, removed iron from transferrin only under reductive conditions. The reaction required a bicarbonate-labilizing anion such as nitrilotriacetate in order for reduction and release of iron to the thiosemicarbazone to occur.
E, Ankel, D H, Petering
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