Results 261 to 270 of about 53,650 (299)
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Iron mobilization from ferritin by chelating agents
Journal of Inorganic Biochemistry, 1980The release of iron from horse spleen ferritin by the chelating agents desferrioxamine B, rhodotorulic acid, 2,3-dihydroxybenzoate, 2,2'-bipyridyl and pyridine-2-aldehyde-2-pyridyl hydrazone (Paphy) has been studied in vitro. Ferritin prepared by classical procedures involving thermal denaturation releases its iron less effectively than ferritin ...
R R, Crichton, F, Roman, F, Roland
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Chelating Agents for the Treatment of Systemic Iron Overload
Current Medicinal Chemistry, 2012The first successful therapeutic iron chelator was desferrioxamine which was introduced in the late 1960's by Ciba (now Novartis). Desferrioxamine has been an extremely successful compound having received the MMW "Pharmaceutical of the year" award for 1991. It is a life saving and a life - prolonging drug which improves the quality of life.
Ma, Yongmin +3 more
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Antioxidant and Iron-chelating Agents in Cerebral Vasospasm
Neurosurgery, 1995Prior work in our laboratory showed that the perivascular application of deferoxamine (an antioxidant and iron-chelating agent) inhibited delayed arterial narrowing after chronic blood exposure in a rat femoral artery model of vasospasm. To determine which of these mechanisms was operant in vasospasm, we compared deferoxamine with two agents (ascorbic ...
Z, Luo +4 more
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Iron mobilization from transferrin by therapeutic iron chelating agents
Biochimica et Biophysica Acta (BBA) - General Subjects, 2012The bacteriostatic activity of the transferrin family has been known since the early 1960's. The possession of high affinity iron(III)-binding sites and the existence of a specific membrane-bound receptor, have led to the present understanding of serum transferrin acting as the major iron transporter between cells in vertebrate systems.
Evans, Robert W. +2 more
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Iron-chelating agents and the reductive removal of iron from transferrin
Biochemical Pharmacology, 1980Abstract 2-Formylpyridine thiosemicarbazone, a strong iron (II) and iron(III)-chelating agent, removed iron from transferrin only under reductive conditions. The reaction required a bicarbonate-labilizing anion such as nitrilotriacetate in order for reduction and release of iron to the thiosemicarbazone to occur.
E, Ankel, D H, Petering
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Iron chelators as therapeutic agents for the treatment of cancer
Critical Reviews in Oncology/Hematology, 2002A wide variety of studies in vitro, in vivo, and in clinical trials have demonstrated that the chelator currently used to treat iron overload disease, desferrioxamine, has anti-proliferative effects against both leukemia and neuroblastoma. However, the efficacy of desferrioxamine is severely limited due to its poor ability to permeate cell membranes ...
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Iron chelating agents with clinical potential
Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences, 1992Synopsis:Iron is a critically important metal for a wide variety of cellular events. The element holds this central position by virtue of its facile redox chemistry and the high affinity of both redox states (iron II and iron III) for oxygen. These same properties also render iron toxic when levels exceed the normal binding capacity of the cell.
R. C. Hider, S. Singh, J. B. Porter
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Potential of iron chelators as effective antiproliferative agents
Canadian Journal of Physiology and Pharmacology, 1997Initially the impetus to develop iron (Fe) chelators for clinical use was based upon the need for a drug to treat Fe-overload diseases such as beta-thalassemia. However, it has become clear that Fe chelators may be useful for the treatment of a wide variety of disease states, including cancer, malaria, and free radical mediated injury.
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Determination of Iron Chelating Agents by Analytical Methods: A Review
Critical Reviews in Analytical Chemistry, 2019Acute iron poisoning and chronic iron overload consequences in significant morbidity and mortality worldwide. Treatment of acute iron poisoning and chronic iron overload can be challenging and care providers are often tackled with management dilemmas. Iron chelating agents are commonly prescribed for patients with iron deficiency anemia. In this review
Aamir, Malik +4 more
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The Behaviour of Iron Chelating Agents with Plants
Journal of Experimental Botany, 1965The absorption by normal and iron-deficient bean plants of Fe and of ethylene diamine-bis-(orthohydroxyphenylacetic acid) (EDHPA) is described; and the metabolism in plants of this chelating agent and of ethylenediaminetetra-acetic acid (EDTA) is examined using 14C-labelled compounds.
D. G. HILL-COTTINGHAM, C. P. LLOYD-JONES
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