Production of pili, hemolysin and siderophores in the urinary isolates of Escherichia coli [PDF]
Introduction. Escherichia coli (E. coli) are the most frequent cause of the urinary tract infections. Uropathogenic E. coli (UPEC) produce virulence factors which enable them to survive in the urinary tract and cause an infection. Objective.
Marković Tatjana+2 more
doaj +1 more source
Tumor Microenvironment‐responsive Nanocatalyst for Targeted Chemodynamic Cancer Therapy
An Tumor microenvironment‐responsive nanocatalyst system composed of PLGA‐encapsulated Ca–Fe peroxide and polyarginine enables sustainable Fenton reaction in tumors. Low levels of H2O2 (50–100 µm) initiate the nanoparticle degradation, while polyarginine‐derived nitric oxide accelerates Fe3+ reduction, leading to self‐amplifying •OH generation for ...
Jun Ma, Jingjing Qiu, Shiren Wang
wiley +1 more source
Organometallic iridium(III) anticancer complexes with new mechanisms of action: NCI-60 screening, mitochondrial targeting, and apoptosis [PDF]
Platinum complexes related to cisplatin, cis-[PtCl2(NH3)2], are successful anticancer drugs; however, other transition metal complexes offer potential for combating cisplatin resistance, decreasing side effects, and widening the spectrum of activity ...
Bailey H. H.+67 more
core +1 more source
SYNTHESIS OF N- ACETONITRIL AND N- ETHYLAMINE- 3- HYDROXYPYRIDINONES AS IRON (III) CHELATORS
<font><font color="#555555"><span style="font-size: 10pt; font-family: Tahoma">Background. The need of iron-chelating agents as orally active alternatives to desferal for the treatment of iron overload in thalassaemic patients, has ...
L.A. SAGHAEI
doaj
BackgroundDespite all efforts, iron deficiency anemia remains a serious public health problem among Brazilian children.ObjectiveTo evaluate dietary iron intake and dietary practices that interfere with the absorption of this nutrient from three regions ...
Carlos Alberto Nogueira-de-Almeida+5 more
doaj +1 more source
Granular hydrogels are emerging microporous platforms for cell culture and delivery, showing great potential for replicating the complex, heterogeneous environments found in natural tissues. This review outlines the design principles of granular hydrogels, highlighting critical factors that determine the final physicochemical properties of the entire ...
Shuhan Feng, Kaiyang Chen, Shiqi Wang
wiley +1 more source
Designing organometallic compounds for catalysis and therapy [PDF]
Bioorganometallic chemistry is a rapidly developing area of research. In recent years organometallic compounds have provided a rich platform for the design of effective catalysts, e.g. for olefin metathesis and transfer hydrogenation.
Abraha Habtemariam+188 more
core +1 more source
Mesoporous Bioactive Glasses: A Powerful Tool in Tissue Engineering and Drug Delivery
This work is a comprehensive revision of bioactive glasses (BGs), pioneered by Prof. L.L. Hench, which are key in bone repair and regenerative medicine. Sol–gel methods and mesoporous designs enhanced their bioactivity, ions, and drug delivery. BGs now support gene therapy and 3D‐printed scaffolds, enabling personalized, multifunctional treatments in ...
Natividad Gómez‐Cerezo+3 more
wiley +1 more source
Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia [PDF]
Differentiating agents have been proposed to overcome the impaired cellular differentiation in acute myeloid leukemia (AML). However, only the combinations of all-trans retinoic acid or arsenic trioxide with chemotherapy have been successful, and only in
Agarwal, Saurabh+22 more
core +2 more sources
Sideróforos: uma resposta dos microorganismos Siderophores: a microorganism's answer
Siderophores (from the Greek: "iron carriers") are defined as relatively low molecular weight, ferric ion specific chelating agents elaborated by microorganisms growing under low iron stress.
Anna Maria Canavarro Benite+2 more
doaj +1 more source