Results 71 to 80 of about 2,460,643 (240)
Advanced Science, EarlyView.The engineered MMS@TRP microgel enables targeted, acid‐responsive delivery of a miR‐21 inhibitor to pericytes. It effectively suppresses disc fibrosis by inhibiting TGF‐β signaling while protecting nucleus pulposus cells via sustained, antioxidant tannic acid release.
Fei Ma +12 more
wiley +1 more source
Anemia, 2011 Thalassaemia and other haemoglobinopathies constitute an important health problem in Mediterranean countries, placing a tremendous emotional, psychological, and economic burden on their National Health systems.
Adriana Ceci +8 more
doaj +1 more source
Using Iron-Chelating Agents in Critically Ill Patients with Iron Overload. Fact or Fiction?
, 2020 Recently, some evidence has shown that the failure of iron homeostasis may occur in critically ill patients and can lead to iron overload (1, 2). Elevated ferritin levels as a body iron burden index in critically ill patients may be associated with ...
Darvishi-Khezri, Hadi +2 more
core +1 more source
Advanced Science, EarlyView.Scalable synthesis of single‐crystal mid‐nickel cathodes demands precise kinetic control over competing densification and grain growth. Oxygen partial pressure emerges as a quantitative descriptor of effective grain‐boundary mobility, acting through changes in the apparent sintering activation barrier.
Hyeonho Park +9 more
wiley +1 more source
Porphyrin‐Based Porous Materials for Antibacterial Applications
Advanced Science, EarlyView.Porphyrin‐based porous materials have excellent photophysical properties and tunable structures for high‐efficiency antibacterial therapy. This review comprehensively discusses the structural design strategies and synthetic pathways of the four main types of porphyrin‐based porous materials, summarizes their cross‐domain antimicrobial applications, and
Xiao‐Xue Liang +4 more
wiley +1 more source
Therapeutics and Clinical Risk Management, 2016 Anna W Chalmers, Jamile M Shammo Department of Internal Medicine, Division of Hematology/Oncology, Rush University Medical Center, Chicago, IL, USA Abstract: Transfusion-dependent anemia is a common feature in a wide array of hematological disorders ...
Chalmers AW, Shammo JM
doaj
Advanced Science, EarlyView.We fabricated a thermoelectric nanomedicine to disrupt the ATP energy supply for the copper transporter ATP7B, thereby enhancing cuproptosis and achieving synergistic immunotherapy for anti‐tumor purposes. The fabricated TBCT NFs can efficiently disrupt the electron transport chain function via superoxide‐induced NADH oxidation, leading to ATP ...
Haoyang Du +13 more
wiley +1 more source
Stabilizing Functional Nucleic Acids for Real‐Sample Diagnostics
Angewandte Chemie, EarlyView.Functional nucleic acids enable programmable real‐sample diagnostics, but often lose function in complex biological matrices. This review highlights four stabilization levers—chemical, topological, architectural, and microenvironment/interface engineering—that preserve aptamer and DNAzyme performance in saliva, serum, urine, and stool, reframing ...
Soyeon Lee +4 more
wiley +2 more sources
Reductive Mobilization of Iron from Intact Ferritin: Mechanisms and Physiological Implication
Pharmaceuticals, 2018 Ferritins are highly conserved supramolecular protein nanostructures composed of two different subunit types, H (heavy) and L (light). The two subunits co-assemble into a 24-subunit heteropolymer, with tissue specific distributions, to form shell-like ...
Fadi Bou-Abdallah +3 more
doaj +1 more source
Advanced Science, EarlyView.This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun +12 more
wiley +1 more source