Results 131 to 140 of about 1,084,666 (382)

Iron chelation therapy in transfusion-dependent thalassemia patients: current strategies and future directions

open access: yesJournal of Blood Medicine, 2015
Antoine N Saliba, Afif R Harb, Ali T Taher Department of Internal Medicine, Division of Hematology/Oncology, American University of Beirut, Beirut, Lebanon Abstract: Transfusional iron overload is a major target in the care of patients with transfusion ...
Saliba AN, Harb AR, Taher AT
doaj  

Combination therapies in iron chelation

open access: yesThalassemia Reports, 2014
The availability of oral iron chelators and new non-invasive methods for early detection and treatment of iron overload, have significantly improved the life expectancy and quality of life of patients with b thalassemia major. However, monotherapy is not
Raffaella Origa
doaj   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

open access: yesAdvanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou   +10 more
wiley   +1 more source

Exploitation of siderophores for the speciation of iron [PDF]

open access: yes, 2011
Iron is essential for life. It acts as an electron donor/acceptor in metabolic processes facilitated by its variable valency. Although vital, it is toxic at high levels due to Fe2+ oxidation. Iron toxicity is a concern as it can affect growth and product
Clarke, Paul A.   +5 more
core  

Degradable and Recyclable 3D‐Printed Pheromones Delivery System Reinforced by Metal Coordination Cross‐Linking for Efficient Pest Trapping

open access: yesAdvanced Science, EarlyView.
This study presents a 3D‐printed carrier for the slow release of insect pheromones. Reinforced by lignosulfonate and Fe³⁺ coordination in a cellulose acetate matrix, it enables sustained release for up to six weeks with remarkable trapping efficacy. Featuring soil degradability and recyclable re‐printing capability, this carrier provides a sustainable ...
Teng Wang   +6 more
wiley   +1 more source

Third-degree heart block in thalassemia major: A case report [PDF]

open access: yes, 2012
Background: First and second-degree heart blocks are partly common rhythm disorders in thalassemic patients but complete heart block is a very rare complication of iron overload cardiomyopathy.
Hosseini, S.M., Maleki, A.R., Nikyar, B.
core   +1 more source

A Systemic Selective Modified mRNA Delivery Platform for Preventing Chemotherapy‐Induced Cardiotoxicity

open access: yesAdvanced Science, EarlyView.
In Yoo and Mainkar et al., we present a minimally invasive, CM‐selective modRNA delivery system encapsulated in lipid nanoparticles for intravenous (IV) administration. This platform enables selective cardiac translation of therapeutic modRNA but suppresses expression in off‐target tissues, including tumors.
Jimeen Yoo   +19 more
wiley   +1 more source

Reducing the iron burden and improving survival in transfusion-dependent thalassemia patients: current perspectives

open access: yesJournal of Blood Medicine, 2016
Karim Bayanzay, Lama Alzoebie Department of Hematology, Gulf Medical University, Ajman, United Arab Emirates Abstract: Hypertransfusion regimens for thalassemic patients revolutionized the management of severe thalassemia; transforming a disease ...
Bayanzay K, Alzoebie L
doaj  

Chronic hyperplastic anemia as an independent risk factor for atherosclerotic lesions: a lesson from thalassemia intermedia [PDF]

open access: yes, 2010
Introduction. Cardiovascular involvement represents a well-known complication and the primary cause of mortality, both in transfusion-dependent beta thalassemia major (β-TM) and in transfusion-independent beta thalassemia intermedia (β-TI ...
Alessandra Spiga   +7 more
core   +1 more source

Salivary proline-rich protein may reduce tannin-iron chelation: a systematic narrative review

open access: yesNutrition and Metabolism, 2017
BackgroundTannins are often cited for antinutritional effects, including chelation of non-heme iron. Despite this, studies exploring non-heme iron bioavailability inhibition with long-term consumption have reported mixed results.
Nicole M Delimont   +3 more
semanticscholar   +1 more source

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