Results 281 to 290 of about 1,030,253 (321)
, 1994 The design of an orally active, non-toxic, selective iron chelator has been a goal of many medical chemists over the past twenty years. Naturally occurring siderophores provide excellent models for such molecules, indeed, desferrioxamine has been and still remains an extremely useful iron chelator.
Surinder Singh +3 more
openaire +2 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Hyperferritinemia in patients with COVID-19: An opportunity for iron chelation?
Artificial Organs, 2020Studies from China on Covid-19 revealed that non-survivors had cytokine storm with high IL-6 and hyperferritinemia. Iron liberated from necrotic cells may catalyze free radical production and amplify lipid peroxidation causing membrane dysfunction and ...
V. Vlahakos +3 more
semanticscholar +1 more source
Hematology/Oncology Clinics of North America, 2008
Effective chelation therapy can prevent or reverse organ toxicity related to iron overload, yet cardiac complications and premature death continue to occur, largely related to difficulties with compliance in patients who receive parenteral therapy. The use of oral chelators may be able to overcome these difficulties and improve patient outcomes.
Janet L. Kwiatkowski +1 more
openaire +4 more sources
Effective chelation therapy can prevent or reverse organ toxicity related to iron overload, yet cardiac complications and premature death continue to occur, largely related to difficulties with compliance in patients who receive parenteral therapy. The use of oral chelators may be able to overcome these difficulties and improve patient outcomes.
Janet L. Kwiatkowski +1 more
openaire +4 more sources
CRC Critical Reviews in Clinical Laboratory Sciences, 1988
Because of the catalytic action of iron in one-electron redox reactions, it has a key role in the formation of harmful oxygen derivatives and production of peroxidative damage to vital cellular structures. The clinical manifestations of iron overload may be prevented and even reversed by the effective administration of the iron-chelating drug ...
David J. Weatherall +2 more
openaire +3 more sources
Because of the catalytic action of iron in one-electron redox reactions, it has a key role in the formation of harmful oxygen derivatives and production of peroxidative damage to vital cellular structures. The clinical manifestations of iron overload may be prevented and even reversed by the effective administration of the iron-chelating drug ...
David J. Weatherall +2 more
openaire +3 more sources
Effects of Iron Chelation in Osteosarcoma
Current Cancer Drug Targets, 2021Background: Osteosarcoma is an aggressive bone tumor. Itrepresents the principal cause of cancer-associated death in children.Considering the recent findings on the role of iron in cancer, iron chelation has been investigated for its antineoplastic properties in many tumors.
Argenziano, Maura +8 more
openaire +4 more sources
Journal of the American Medical Association, 1958
Administration of effective doses of iron in the treatment of iron deficiency anemia is complicated by the fact that iron compounds are not innocuous. Toxicity experiments on dogs and rabbits are here summarized; they showed that the concentration of iron attained in the animal's serum determined the severity of the acute symptoms.
W G Rohse +3 more
openaire +3 more sources
Administration of effective doses of iron in the treatment of iron deficiency anemia is complicated by the fact that iron compounds are not innocuous. Toxicity experiments on dogs and rabbits are here summarized; they showed that the concentration of iron attained in the animal's serum determined the severity of the acute symptoms.
W G Rohse +3 more
openaire +3 more sources
2002
Iron overload is a serious clinical condition which can be largely prevented by the use of iron-specific chelating agents. Desferrioxamine-B(1)the most widely used iron chelator in haematology over the past thirty years, has a major disadvantage of being orally inactive’.
Liu, Z D, Liu, D Y, Hider, R C
openaire +3 more sources
Iron overload is a serious clinical condition which can be largely prevented by the use of iron-specific chelating agents. Desferrioxamine-B(1)the most widely used iron chelator in haematology over the past thirty years, has a major disadvantage of being orally inactive’.
Liu, Z D, Liu, D Y, Hider, R C
openaire +3 more sources
Hydroxyquinolines as Iron Chelators
Current Medicinal Chemistry, 2003The interest in synthetic siderophore mimics includes therapeutic applications (iron chelation therapy), the design of more effective agents to deliver Fe to plants and the development of new chemical tools for studies of iron metabolism and for a better understanding of iron assimilation processes in living systems.
G. Serratrice +2 more
openaire +2 more sources
The Role of Deferiprone in Iron Chelation.
New England Journal of Medicine, 2018Iron Chelation Iron overload can compromise the cardiac, hepatic, renal, and endocrine systems. Orally active iron chelators increase iron excretion, and in some instances, the combination of oral ...
R. Hider, A. Hoffbrand
semanticscholar +1 more source
Biochimica et Biophysica Acta, 1963
Abstract Reducing sugars and polyols are shown to form soluble stable complexes with a series of metal ions at alkaline pH. Several properties of an iron-fructose complex have been studied. The specific conditions of pH and concentrations of iron and fructose necessary for complex formation are described. Evidence for the existence of the complex is (
Paul Saltman +3 more
openaire +3 more sources
Abstract Reducing sugars and polyols are shown to form soluble stable complexes with a series of metal ions at alkaline pH. Several properties of an iron-fructose complex have been studied. The specific conditions of pH and concentrations of iron and fructose necessary for complex formation are described. Evidence for the existence of the complex is (
Paul Saltman +3 more
openaire +3 more sources