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Therapeutic Macromolecular Iron Chelators
Current Medicinal Chemistry, 2019Iron is a key element for every single living process. On a fundamental level, targeting iron is a valuable approach for the treatment of disorders caused by iron overload. Utilizing iron chelators as therapeutic agents has received expanding consideration in chelation therapy.
Upendra, Bulbake +3 more
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Hematology/Oncology Clinics of North America, 2008
Effective chelation therapy can prevent or reverse organ toxicity related to iron overload, yet cardiac complications and premature death continue to occur, largely related to difficulties with compliance in patients who receive parenteral therapy. The use of oral chelators may be able to overcome these difficulties and improve patient outcomes.
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Effective chelation therapy can prevent or reverse organ toxicity related to iron overload, yet cardiac complications and premature death continue to occur, largely related to difficulties with compliance in patients who receive parenteral therapy. The use of oral chelators may be able to overcome these difficulties and improve patient outcomes.
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Combined iron chelation therapy
Annals of the New York Academy of Sciences, 2010Patients with thalassemia major accumulate body iron over time as a consequence of continuous red blood cell transfusions which cause hepatic, endocrine, and cardiac complications. Despite the availability of three iron chelators, some patients fail to respond adequately to monotherapy with any of them. Combination therapy, consisting in the use of two
Galanello Renzo +5 more
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Iron chelators and iron toxicity
Alcohol, 2003Iron chelation may offer new approaches to the treatment and prevention of alcoholic liver disease. With chronic excess, either iron or alcohol alone may individually injure the liver and other organs. In combination, each exaggerates the adverse effects of the other.
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Hydroxyquinolines as Iron Chelators
Current Medicinal Chemistry, 2003The interest in synthetic siderophore mimics includes therapeutic applications (iron chelation therapy), the design of more effective agents to deliver Fe to plants and the development of new chemical tools for studies of iron metabolism and for a better understanding of iron assimilation processes in living systems.
J-L, Pierre, P, Baret, G, Serratrice
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Polyamine−Iron Chelator Conjugate
Journal of Medicinal Chemistry, 2003The current study demonstrates unequivocally that polyamines can serve as vectors for the intracellular delivery of the bidentate chelator 1,2-dimethyl-3-hydroxypyridin-4-one (L1). The polyamine-hydroxypyridinone conjugate 1-(12-amino-4,9-diazadodecyl)-2-methyl-3-hydroxy-4(1H)-pyridinone is assembled from spermine and 3-O-benzylmaltol. The conjugate is
Raymond J, Bergeron +4 more
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Reviews in Clinical and Experimental Hematology, 2000
In chronic anemias associated with iron overload, iron chelation therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Although desferrioxamine (DFO) has been available for the treatment of transfusional iron overload since the early 1960s, the era of modern and effective iron chelation ...
Chaim Hershko, A. Victor Hoffbrand
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In chronic anemias associated with iron overload, iron chelation therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Although desferrioxamine (DFO) has been available for the treatment of transfusional iron overload since the early 1960s, the era of modern and effective iron chelation ...
Chaim Hershko, A. Victor Hoffbrand
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Seminars in Hematology, 2001
Iron chelators are used in clinical practice to protect patients from the complications of iron overload and iron toxicity because there is no physiologic way for excess iron to be actively excreted. Deferoxamine, the only iron-chelating agent available for clinical use in the United States, is administered as a prolonged (8 to 24 hours) infusion ...
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Iron chelators are used in clinical practice to protect patients from the complications of iron overload and iron toxicity because there is no physiologic way for excess iron to be actively excreted. Deferoxamine, the only iron-chelating agent available for clinical use in the United States, is administered as a prolonged (8 to 24 hours) infusion ...
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Iron Chelation in Chemotherapy
2003Publisher Summary This chapter discusses the way accumulation of excessive amounts of iron results in the loss of tissue and organ functions. Excessive iron in specific tissue sites promotes infection, neoplasia, cardiomyopathy, arthropathy, and an array of endocrine and neurodegenerative diseases.
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An evolving view on biogeochemical cycling of iron
Nature Reviews Microbiology, 2021Andreas Kappler +2 more
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