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Iron Chelation Nanoparticles with Delayed Saturation as an Effective Therapy for Parkinson Disease.
Biomacromolecules, 2017Iron accumulation in substantia nigra pars compacta (SNpc) has been proved to be a prominent pathophysiological feature of Parkinson's diseases (PD), which can induce the death of dopaminergic (DA) neurons, up-regulation of reactive oxygen species (ROS),
Nan Wang +4 more
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Reviews in Clinical and Experimental Hematology, 2000
In chronic anemias associated with iron overload, iron chelation therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Although desferrioxamine (DFO) has been available for the treatment of transfusional iron overload since the early 1960s, the era of modern and effective iron chelation ...
A. Victor Hoffbrand, Chaim Hershko
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In chronic anemias associated with iron overload, iron chelation therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Although desferrioxamine (DFO) has been available for the treatment of transfusional iron overload since the early 1960s, the era of modern and effective iron chelation ...
A. Victor Hoffbrand, Chaim Hershko
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Iron Chelation in Chemotherapy
2003Publisher Summary This chapter discusses the way accumulation of excessive amounts of iron results in the loss of tissue and organ functions. Excessive iron in specific tissue sites promotes infection, neoplasia, cardiomyopathy, arthropathy, and an array of endocrine and neurodegenerative diseases.
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International Journal for Vitamin and Nutrition Research, 2004
Iron amino acid chelates, such as iron glycinate chelates, have been developed to be used as food fortificants and therapeutic agents in the prevention and treatment of iron deficiency anemia. Ferrous bis-glycine chelate (FeBC), ferric tris-glycine chelate, ferric glycinate, and ferrous bis-glycinate hydrochloride are available commercially.
Manuel Olivares, Eva Hertrampf
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Iron amino acid chelates, such as iron glycinate chelates, have been developed to be used as food fortificants and therapeutic agents in the prevention and treatment of iron deficiency anemia. Ferrous bis-glycine chelate (FeBC), ferric tris-glycine chelate, ferric glycinate, and ferrous bis-glycinate hydrochloride are available commercially.
Manuel Olivares, Eva Hertrampf
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Blood Reviews, 2002
In patients with transfusion-dependent anemias, iron accumulation is fatal in the absence of chelating therapy. Extended survival, free of most complications of iron overload is observed in patients treated with early, adequate parenteral deferoxamine.
N. Olivier, Laura Merson
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In patients with transfusion-dependent anemias, iron accumulation is fatal in the absence of chelating therapy. Extended survival, free of most complications of iron overload is observed in patients treated with early, adequate parenteral deferoxamine.
N. Olivier, Laura Merson
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Seminars in Hematology, 2001
Iron chelators are used in clinical practice to protect patients from the complications of iron overload and iron toxicity because there is no physiologic way for excess iron to be actively excreted. Deferoxamine, the only iron-chelating agent available for clinical use in the United States, is administered as a prolonged (8 to 24 hours) infusion ...
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Iron chelators are used in clinical practice to protect patients from the complications of iron overload and iron toxicity because there is no physiologic way for excess iron to be actively excreted. Deferoxamine, the only iron-chelating agent available for clinical use in the United States, is administered as a prolonged (8 to 24 hours) infusion ...
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Iron Chelation with Desferrioxamine.
Annals of Internal Medicine, 1964Excerpt Desferrioxamine (DF), an iron chelating substance, was given parenterally to four patients with idiopathic hemochromatosis, eight patients with cirrhosis of the liver associated with variou...
Frederic W. Smith +3 more
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The role of chelation in iron metabolism
Journal of Chemical Education, 1965The regulation and control of iron metabolism through the intestine as well as across all biological membranes is determined by the ability of the iron to be chelated by low molecular weight ligands.
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Photosensitivity of Iron Chelates
Nature, 1955DURING work with iron chelates, it was noted that many chemical analyses for total iron were inconsistent when repeated at intervals on solutions left standing on the laboratory bench in the light. A sensitive method was then devised for the estimation of the chelated iron molecule as a whole, based on the light-absorption of solutions in the ultra ...
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