Results 51 to 60 of about 1,030,253 (321)

Iron chelation therapy improves hematopoiesis in patients with hematological malignancy after hematopoietic stem cell transplantation

Di-san junyi daxue xuebao, 2021
Objective To investigate the effect and safety of iron chelation therapy on hematopoiesis in hematological malignancy patients with iron overload after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
ZENG Cong, CHEN Xu, HUA Juan, CHENG Tingting, MA Xia, XU Yajing   +5 more
doaj   +1 more source

A decrease in iron availability to human gut microbiome reduces the growth of potentially pathogenic gut bacteria: an in vitro colonic fermentation study [PDF]

, 2019
Iron-supplements are widely consumed; however most of the iron is not absorbed and enters the colon where potentially pathogenic bacteria can utilise it for growth.
Basit, Abdul W., Fairweather-Tait, Susan, Kellingray, Lee, Le Gall, Gwenaelle, Narbad, Arjan, Parmanand, Bhavika A   +5 more
core   +2 more sources

Iron and Chelation in Biochemistry and Medicine: New Approaches to Controlling Iron Metabolism and Treating Related Diseases

Cells, 2020
Iron is essential for all living organisms. Many iron-containing proteins and metabolic pathways play a key role in almost all cellular and physiological functions.
G. Kontoghiorghes, C. Kontoghiorghe
semanticscholar   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Trying to Solve the Puzzle of the Interaction of Ascorbic Acid and Iron: Redox, Chelation and Therapeutic Implications

Medicines, 2020
Iron and ascorbic acid (vitamin C) are essential nutrients for the normal growth and development of humans, and their deficiency can result in serious diseases.
G. Kontoghiorghes, A. Kolnagou, C. Kontoghiorghe, Loukia Mourouzidis, V. A. Timoshnikov, N. Polyakov   +5 more
semanticscholar   +1 more source

The role of iron and iron chelators in zygomycosis [PDF]

Clinical Microbiology and Infection, 2009
Iron is an essential element for cell growth and development, contributing to DNA synthesis and regulating the G(1)-phase to S-phase transition. Moreover, iron is important for the virulence of the majority of microorganisms, and the function of the genes regulating iron uptake is coupled with the manifestations of the virulence phenotype.
openaire   +3 more sources

Self‐Cascade Catalytic Reaction–Assisted Apoptosis/Calcicoptosis/Ferroptosis Induction with Microsphere‐Aggregated Hydrogels in Triple‐Negative Breast Cancer Therapy

Advanced Functional Materials, EarlyView.
Hyaluronic acid‐dopamine‐based intra‐crosslinked microsphere including cisplatin (HPC MS) is fabricated by spray‐drying and calcium/iron ions are introduced for interparticle crosslinking. Designed microsphere‐aggregated hydrogel (MAH) system including cisplatin/CaO2/FeSO4 can provide apoptosis/calcicoptosis/ferroptosis‐mediated chemo/cascade ...
ChaeRim Hwang, Yeoung Eun Choi, Song Yi Lee, Mrinmoy Karmakar, Qiaojun Hao, Junmin Lee, Hyun‐Jong Cho   +6 more
wiley   +1 more source

Erythrocytapheresis as a strategy to manage anemia and iron overload in nondeletional hemoglobin H disease

eJHaem
Hemoglobin H (HbH) disease is associated with anemia, ineffective erythropoiesis, and iron overload. We report a case of a patient with HbH/Hb Constant Spring disease, who was maintained on chronic transfusions as an adult due to symptomatic anemia. Over
Ke Zhang, John Bliamptis, Janice Park, Patricia Kopko, Amber P. Sanchez, Srila Gopal   +5 more
doaj   +1 more source

Sex and Gender Differences in Iron Chelation

Biomedicines
Background/Objectives: In the absence of physiological mechanisms to excrete excessive iron, the administration of iron chelation therapy is necessary.
Sarah Allegra, Stefano Comità, Antonella Roetto, Silvia De Francia   +3 more
doaj   +1 more source

Beliefs about chelation among thalassemia patients

Health and Quality of Life Outcomes, 2012
Background Understanding patients’ views about medication is crucial to maximize adherence. Thalassemia is a congenital blood disorder requiring chronic blood transfusions and daily iron chelation therapy.
Trachtenberg Felicia L, Mednick Lauren, Kwiatkowski Janet L, Neufeld Ellis J, Haines Dru, Pakbaz Zahra, Thompson Alexis A, Quinn Charles T, Grady Robert, Sobota Amy, Olivieri Nancy, Horne Robert, Yamashita Robert   +12 more
doaj   +1 more source