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Iron metabolism and atherosclerosis
Trends in Endocrinology & Metabolism, 2023Despite several decades of study, whether iron is involved in the development of atherosclerosis remains a controversial and unresolved issue. Here, we focus on the up-to-date advances in studies on role of iron in atherosclerosis and discuss possible reasons why patients with hereditary hemochromatosis (HH) do not show any increased incidence of ...
Qian Guo +2 more
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Targeting iron metabolism in drug discovery and delivery [PDF]
Nature Reviews Drug Discovery, 2017 Iron fulfils a central role in many essential biochemical processes in human physiology; thus, proper processing of iron is crucial. Although iron metabolism is subject to relatively strict physiological control, numerous disorders, such as cancer and ...
Stefano Rivella +2 more
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Pediatrics, 1956
THE CLINICIAN has long been aware of the fact that iron deficiency anemia is most prevalent during infancy. Continuing studies of iron metabolism have disclosed many factors which help explain the basic mechanisms of the anemia and the peculiar vulnerability of the infant.
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THE CLINICIAN has long been aware of the fact that iron deficiency anemia is most prevalent during infancy. Continuing studies of iron metabolism have disclosed many factors which help explain the basic mechanisms of the anemia and the peculiar vulnerability of the infant.
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Medical Clinics of North America, 1980
Although iron in minute amounts is necessary for the metabolism of most cells, it produces damage if present in excess. Clinical tools for the evaluation of iron stores include serum iron concentration, transferrin saturation, deferoxamine test, Prussian blue stains of liver and marrow, and serum ferritin concentration.
N, Nimeh, R C, Bishop
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Although iron in minute amounts is necessary for the metabolism of most cells, it produces damage if present in excess. Clinical tools for the evaluation of iron stores include serum iron concentration, transferrin saturation, deferoxamine test, Prussian blue stains of liver and marrow, and serum ferritin concentration.
N, Nimeh, R C, Bishop
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Absorption and Metabolism of Iron
Science, 1956In the article "Absorption and metabolism of iron" [Science 123, 87 (20 Jan. 1955)], the wavelength of maximum absorption of the iron-siderophilin complex was incorrectly given as 520 millimicrons. On page 89, the first sentence in the second paragraph under the heading "Iron transport" should read "The Fe+++-B(1)-globulin complex has a characteristic ...
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Arteriosclerosis and iron metabolism
Journal of Surgical Research, 1970Abstract Serum iron was studied in 50 patients with known calcific arteriosclerosis. These patients were divided into three groups of severe, moderate, and mild cases. It was found that patients with severe calcific arteriosclerosis have relatively lower serum-free iron and higher liver-iron deposition.
S, Gerami +3 more
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Seminars in Pediatric Neurology, 2006
Brain iron uptake is regulated by the expression of transferrin receptor 1 in endothelial cells of the blood-brain barrier. Transferrin-bound iron in the systemic circulation is endocytosed by brain endothelial cells, and elemental iron is released to brain interstitial fluid, likely by the iron exporter, ferroportin.
Tracey A, Rouault, Sharon, Cooperman
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Brain iron uptake is regulated by the expression of transferrin receptor 1 in endothelial cells of the blood-brain barrier. Transferrin-bound iron in the systemic circulation is endocytosed by brain endothelial cells, and elemental iron is released to brain interstitial fluid, likely by the iron exporter, ferroportin.
Tracey A, Rouault, Sharon, Cooperman
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Toxicology Mechanisms and Methods, 2007
ABSTRACT Iron is an essential transition metal for mammalian cellular and tissue viability. It is critical to supplying oxygen through heme, the mitochondrial respiratory chain, and enzymes such as ribonucleotide reductase. Mammalian organisms have evolved with the means of regulating the metabolism of iron, because if left unregulated, the resulting ...
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ABSTRACT Iron is an essential transition metal for mammalian cellular and tissue viability. It is critical to supplying oxygen through heme, the mitochondrial respiratory chain, and enzymes such as ribonucleotide reductase. Mammalian organisms have evolved with the means of regulating the metabolism of iron, because if left unregulated, the resulting ...
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The American Journal of Clinical Nutrition, 1990
Humans can adapt successfully to a wide range of iron requirements and intakes. The lower limit of the adapted state is best defined by serum ferritin greater than or equal to 12 micrograms/L, because lower values indicate that iron stores are fully depleted.
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Humans can adapt successfully to a wide range of iron requirements and intakes. The lower limit of the adapted state is best defined by serum ferritin greater than or equal to 12 micrograms/L, because lower values indicate that iron stores are fully depleted.
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The American Journal of Clinical Nutrition, 1977
An important component of nonspecific defense of vertebrates against microbial invasion is that of nutritional immunity. Hosts attempt to withhold growth-essential iron from invading bacteria, fungi, and protozoa. Clinical conditions in which hosts are stressed by excess quantities of iron in specific fluids, tissues, or cells result in enhanced ...
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An important component of nonspecific defense of vertebrates against microbial invasion is that of nutritional immunity. Hosts attempt to withhold growth-essential iron from invading bacteria, fungi, and protozoa. Clinical conditions in which hosts are stressed by excess quantities of iron in specific fluids, tissues, or cells result in enhanced ...
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