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International Journal of Molecular Sciences, 2022 Iron homeostasis disruption has increasingly been implicated in various neurological disorders. In this review, we present an overview of our current understanding of iron metabolism in the central nervous system. We examine the consequences of both iron
Christina A Porras +2 more
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Iron Metabolism in Aging and Age-Related Diseases [PDF]
International Journal of Molecular Sciences, 2022 Iron is a trace metal element necessary to maintain life and is also involved in a variety of biological processes. Aging refers to the natural life process in which the physiological functions of the various systems, organs, and tissues decline ...
Yuanliangzi Tian +2 more
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Iron metabolism and atherosclerosis
Trends in Endocrinology & Metabolism, 2023Despite several decades of study, whether iron is involved in the development of atherosclerosis remains a controversial and unresolved issue. Here, we focus on the up-to-date advances in studies on role of iron in atherosclerosis and discuss possible reasons why patients with hereditary hemochromatosis (HH) do not show any increased incidence of ...
Qian Guo +2 more
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Current Opinion in Chemical Biology, 1999
The understanding of iron metabolism at the molecular level has been enormously expanded in recent years by new findings about the functioning of transferrin, the transferrin receptor and ferritin. Other recent developments include the discovery of the hemochromatosis gene HFE, identification of previously unknown proteins involved in iron transport ...
P, Aisen +2 more
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The understanding of iron metabolism at the molecular level has been enormously expanded in recent years by new findings about the functioning of transferrin, the transferrin receptor and ferritin. Other recent developments include the discovery of the hemochromatosis gene HFE, identification of previously unknown proteins involved in iron transport ...
P, Aisen +2 more
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Pediatrics, 1956
THE CLINICIAN has long been aware of the fact that iron deficiency anemia is most prevalent during infancy. Continuing studies of iron metabolism have disclosed many factors which help explain the basic mechanisms of the anemia and the peculiar vulnerability of the infant.
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THE CLINICIAN has long been aware of the fact that iron deficiency anemia is most prevalent during infancy. Continuing studies of iron metabolism have disclosed many factors which help explain the basic mechanisms of the anemia and the peculiar vulnerability of the infant.
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Medical Clinics of North America, 1980
Although iron in minute amounts is necessary for the metabolism of most cells, it produces damage if present in excess. Clinical tools for the evaluation of iron stores include serum iron concentration, transferrin saturation, deferoxamine test, Prussian blue stains of liver and marrow, and serum ferritin concentration.
N, Nimeh, R C, Bishop
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Although iron in minute amounts is necessary for the metabolism of most cells, it produces damage if present in excess. Clinical tools for the evaluation of iron stores include serum iron concentration, transferrin saturation, deferoxamine test, Prussian blue stains of liver and marrow, and serum ferritin concentration.
N, Nimeh, R C, Bishop
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Arteriosclerosis and iron metabolism
Journal of Surgical Research, 1970Abstract Serum iron was studied in 50 patients with known calcific arteriosclerosis. These patients were divided into three groups of severe, moderate, and mild cases. It was found that patients with severe calcific arteriosclerosis have relatively lower serum-free iron and higher liver-iron deposition.
S, Gerami +3 more
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Seminars in Pediatric Neurology, 2006
Brain iron uptake is regulated by the expression of transferrin receptor 1 in endothelial cells of the blood-brain barrier. Transferrin-bound iron in the systemic circulation is endocytosed by brain endothelial cells, and elemental iron is released to brain interstitial fluid, likely by the iron exporter, ferroportin.
Tracey A, Rouault, Sharon, Cooperman
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Brain iron uptake is regulated by the expression of transferrin receptor 1 in endothelial cells of the blood-brain barrier. Transferrin-bound iron in the systemic circulation is endocytosed by brain endothelial cells, and elemental iron is released to brain interstitial fluid, likely by the iron exporter, ferroportin.
Tracey A, Rouault, Sharon, Cooperman
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Absorption and Metabolism of Iron
Science, 1956In the article "Absorption and metabolism of iron" [Science 123, 87 (20 Jan. 1955)], the wavelength of maximum absorption of the iron-siderophilin complex was incorrectly given as 520 millimicrons. On page 89, the first sentence in the second paragraph under the heading "Iron transport" should read "The Fe+++-B(1)-globulin complex has a characteristic ...
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