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Current Protein & Peptide Science, 2005
Hepcidin, which has been recently identified both by biochemical and genomic approaches, is a 25 amino acid polypeptide synthesized mainly by hepatocytes and secreted into the plasma. Besides its potential activity in antimicrobial defense, hepcidin plays a major role in iron metabolism. It controls two key steps of iron bioavailability, likely through
Olivier, Loréal +7 more
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Hepcidin, which has been recently identified both by biochemical and genomic approaches, is a 25 amino acid polypeptide synthesized mainly by hepatocytes and secreted into the plasma. Besides its potential activity in antimicrobial defense, hepcidin plays a major role in iron metabolism. It controls two key steps of iron bioavailability, likely through
Olivier, Loréal +7 more
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Metabolism of iron in the duck
American Journal of Physiology-Legacy Content, 1959In the duck, intravenously injected labeled iron, in amounts that did not exceed 0.1 of the plasma iron, mixed initially with about five times the amount of iron in plasma. The highest level of labeled iron in erythrocytes corresponded to about 0.75 of the injected iron.
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Molecular Aspects of Medicine, 2005
Iron and copper are essential nutrients, excesses or deficiencies of which cause impaired cellular functions and eventually cell death. The metabolic fates of copper and iron are intimately related. Systemic copper deficiency generates cellular iron deficiency, which in humans results in diminished work capacity, reduced intellectual capacity ...
Miguel, Arredondo, Marco T, Núñez
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Iron and copper are essential nutrients, excesses or deficiencies of which cause impaired cellular functions and eventually cell death. The metabolic fates of copper and iron are intimately related. Systemic copper deficiency generates cellular iron deficiency, which in humans results in diminished work capacity, reduced intellectual capacity ...
Miguel, Arredondo, Marco T, Núñez
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New England Journal of Medicine, 1999
Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe2+) and ferrous (Fe3+) forms.
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Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe2+) and ferrous (Fe3+) forms.
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Iron absorption and metabolism
Current Opinion in Gastroenterology, 2009Intestinal iron absorption is an essential physiological process that is regulated by the liver-derived peptide hepcidin. This review will describe recent advances in hepcidin biology and enterocyte iron transport.Hepcidin acts as a repressor of iron absorption and its expression in turn reflects a range of systemic cues, including iron status, hypoxia,
Anderson, Gregory J. +2 more
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Clinical Laboratory
The essential trace element iron, which can occur in various oxidation states, is required for many biochemical reactions and processes in the human body.This review summarizes the current knowledge about the physiology of iron metabolism.The physiological functions comprise oxygen transport in the blood, electron transport processes, DNA synthesis and
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The essential trace element iron, which can occur in various oxidation states, is required for many biochemical reactions and processes in the human body.This review summarizes the current knowledge about the physiology of iron metabolism.The physiological functions comprise oxygen transport in the blood, electron transport processes, DNA synthesis and
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Pediatric Clinics of North America, 2002
Diseases of iron metabolism are likely to be both more frequent than expected, and exhibit a wider range of clinic severity and effects. Some present without evidence of anemia. Unexplained diseases of end organs that are affected by iron (liver, heart, pancreas, kidney, adrenals, and cerebellum) should have an iron metabolism disorder considered ...
Ward, Hagar +2 more
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Diseases of iron metabolism are likely to be both more frequent than expected, and exhibit a wider range of clinic severity and effects. Some present without evidence of anemia. Unexplained diseases of end organs that are affected by iron (liver, heart, pancreas, kidney, adrenals, and cerebellum) should have an iron metabolism disorder considered ...
Ward, Hagar +2 more
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Iron Metabolism: Iron Deficiency and Iron Overload
Annual Review of Genomics and Human Genetics, 2000Iron is an essential cofactor in a variety of cellular processes. Except for a few unusual bacterial species, iron is indispensable for living organisms. However, free iron is toxic because of its propensity to induce the formation of dangerous free radicals. Consequently, iron balance is tightly regulated.
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Journal of Parenteral and Enteral Nutrition, 2012
Iron metabolism in man is a highly regulated process designed to provide iron for erythropoiesis, mitochondrial energy production, electron transport, and cell proliferation. The mechanisms of iron handling also protect cells from the deleterious effects of free iron, which can produce oxidative damage of membranes, proteins, and lipids.
Annette, von Drygalski, John W, Adamson
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Iron metabolism in man is a highly regulated process designed to provide iron for erythropoiesis, mitochondrial energy production, electron transport, and cell proliferation. The mechanisms of iron handling also protect cells from the deleterious effects of free iron, which can produce oxidative damage of membranes, proteins, and lipids.
Annette, von Drygalski, John W, Adamson
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Current Opinion in Hematology, 2004
Hepcidin is a recently discovered hepatic peptide that regulates intestinal iron absorption as well as maternal-fetal iron transport across the placenta. It probably also affects the release of iron from hepatic stores and from macrophages involved in the recycling of iron from hemoglobin.
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Hepcidin is a recently discovered hepatic peptide that regulates intestinal iron absorption as well as maternal-fetal iron transport across the placenta. It probably also affects the release of iron from hepatic stores and from macrophages involved in the recycling of iron from hemoglobin.
openaire +2 more sources