Results 91 to 100 of about 22,432 (259)

Irreversible electroporation: evolution of a laboratory technique in interventional oncology

Diagnostic and Interventional Radiology, 2014
Electroporation involves applying electric field pulses to cells, leading to the alteration or destruction of cell membranes. Irreversible electroporation (IRE) creates permanent defects in cell membranes and induces cell death. By directly targeting IRE
Amy R. Deipolyi,, Alexander Golberg,, Martin L. Yarmush,, Ronald S. Arellano,, Rahmi Oklu   +4 more
doaj   +1 more source

A numerical investigation of the electric and thermal cell kill distributions in electroporation-based therapies in tissue.

PLoS ONE, 2014
Electroporation-based therapies are powerful biotechnological tools for enhancing the delivery of exogeneous agents or killing tissue with pulsed electric fields (PEFs).
Paulo A Garcia, Rafael V Davalos, Damijan Miklavcic   +2 more
doaj   +1 more source

The Effects of Irreversible Electroporation on the Achilles Tendon: An Experimental Study in a Rabbit Model. [PDF]

PLoS ONE, 2015
To evaluate the potential effects of irreversible electroporation ablation on the Achilles tendon in a rabbit model and to compare the histopathological and biomechanical changes between specimens following electroporation ablation and radiofrequency ...
Yue Song, Jingjing Zheng, Mingwei Yan, Weidong Ding, Kui Xu, Qingyu Fan, Zhao Li   +6 more
doaj   +1 more source

Engineering of 2‐ketoacid Decarboxylases for Production of Isobutanol and Other Fusel Alcohols in Saccharomyces cerevisiae

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Isobutanol is a fusel alcohol that can be produced microbially for use as a biofuel or upgraded into sustainable aviation fuel (SAF). A key enzyme in the isobutanol biosynthetic pathway is 2‐ketoacid decarboxylase (KDC), which irreversibly decarboxylates 2‐ketoisovalerate (KIV) to yield isobutyraldehyde.
Joshua J. Dietrich, Maelia Dziedzic, Jia Sun, Sri Harsha Adusumilli, Carla Gonçalves, Chris Todd Hittinger, Brian F. Pfleger   +6 more
wiley   +1 more source

Irreversible electroporation for unresectable liver malignancies

Academia Oncology
Background: Irreversible electroporation (IRE) is a non-thermal ablation technique used for liver tumors that are unresectable due to their proximity to critical structures. This study evaluates outcomes for patients treated with IRE. Methods:
Zili Zhou, Chris Wall, Jeff Bird, Shahid Ahmed, Gavin Beck, John Shaw, Michael A. J. Moser   +6 more
doaj   +1 more source

Mutagenesis of Trichoderma reesei endoglucanase I: impact of expression host on activity and stability at elevated temperatures. [PDF]

, 2015
BackgroundTrichoderma reesei is a key cellulase source for economically saccharifying cellulosic biomass for the production of biofuels. Lignocellulose hydrolysis at temperatures above the optimum temperature of T. reesei cellulases (~50°C) could provide
Atreya, Meera E, Blanch, Harvey W, Chokhawala, Harshal A, Clark, Douglas S, Dana, Craig M, Kim, Tae-Wan, Roche, Christine M, Vegesna, Neeraja   +7 more
core   +3 more sources

Advancing design strategies in smart stimulus‐responsive liposomes for drug release and nanomedicine

BMEMat, EarlyView.
Schematic illustration of stimulus‐responsive liposomes designed for controlled drug release and nanomedicine. The innermost circle represents different liposomal structures, including unilamellar, multilamellar, and multivesicular liposomes. The middle layer illustrates the responsive phospholipid components.
Yuchen Guo, Nan Li, Daiwei Zhang, Jingya Gu, Zhihuan Liao, Zihao Teng, Xiangfu Du, Peter S. Timashev, Shipeng Chen, Shuaidong Huo   +9 more
wiley   +1 more source

Irreversible electroporation: state of the art

OncoTargets and Therapy, 2016
The field of focal ablative therapy for the treatment of cancer is characterized by abundance of thermal ablative techniques that provide a minimally invasive treatment option in selected tumors. However, the unselective destruction inflicted by thermal ablation modalities can result in damage to vital structures in the vicinity of the tumor ...
Wagstaff, Peter G. K., Buijs, Mara, van den Bos, Willemien, de Bruin, Daniel M., Zondervan, Patricia J., de La Rosette, Jean J. M. C. H., Laguna Pes, M. Pilar   +6 more
openaire   +4 more sources

Inhibition of glucocorticoid-induced apoptosis by targeting splice variants of \u3ci\u3eBIM\u3c/i\u3e mRNA with small interfering RNA and short hairpin RNA. [PDF]

, 2004
Glucocorticoids (GCs) induce apoptosis in lymphocytes and are effective agents for the treatment of leukemia. The activated glucocorticoid receptor (GR) initiates a transcriptional program leading to caspase activation and cell death, but the critical ...
Abrams, Marc T., Robertson, Noreen M., Wickstrom, Eric, Yoon, Kyonggeun   +3 more
core   +1 more source

Combination of electroporation delivered metabolic modulators with low-dose chemotherapy in osteosarcoma [PDF]

, 2018
Background: Osteosarcoma accounts for roughly 60% of all malignant bone tumors in children and young adults. The five-year survival rate for localized tumors after surgery and chemotherapy is approximately 70% whilst it drastically reduces to 15–30% in ...
Bird, Brian, Fernandes, Philana, Forde, Patrick F., Gill, Kheshwant S., Soden, Declan M.   +4 more
core   +1 more source