Results 71 to 80 of about 182,783 (241)

Electroporation in Clinical Applications—The Potential of Gene Electrotransfer and Electrochemotherapy

Applied Sciences, 2022
Electroporation (EP) allows for the transport of molecules into the cytoplasm with significant effectiveness by forming transient pores in the cell membrane using electric pulses. This can be used for cellular transport (RE—reversible electroporation) or
Katarzyna Rakoczy, Monika Kisielewska, Mikołaj Sędzik, Laura Jonderko, Julia Celińska, Natalia Sauer, Wojciech Szlasa, Jolanta Saczko, Vitalij Novickij, Julita Kulbacka   +9 more
doaj   +1 more source

Thermal Effects of Irreversible Electroporation

, 2017
Although irreversible electroporation (IRE) is thought to be a nonthermal technique for the ablation of soft tissue, objective temperature measurements and mathematical models have shown that temperature increase during treatment can be significant. The nonthermal mechanism is thought to be caused by a disturbance in the cell’s homeostasis through the ...
Eran van Veldhuisen, J. A. Vogel, J. H. Klaessens, R. M. Verdaasdonk   +3 more
openaire   +1 more source

Investigation of safety for electrochemotherapy and irreversible electroporation ablation therapies in patients with cardiac pacemakers

BioMedical Engineering OnLine, 2020
Background The effectiveness of electrochemotherapy of tumors (ECT) and of irreversible electroporation ablation (IRE) depends on different mechanisms and delivery protocols.
Tomaz Jarm, Tadej Krmac, Ratko Magjarevic, Bor Kos, Helena Cindric, Damijan Miklavcic   +5 more
doaj   +1 more source

Immunologic response to tumor ablation with irreversible electroporation. [PDF]

PLoS ONE, 2012
BACKGROUND: Irreversible electroporation (IRE) is a promising technique for the focal treatment of pathologic tissues, which involves placing minimally invasive electrodes within the targeted region.
Xiaoxiang Li, Kui Xu, Wei Li, Xiuchun Qiu, Baoan Ma, Qingyu Fan, Zhao Li   +6 more
doaj   +1 more source

Preparação de um arranjo experimental para a eletroporação de célula única [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Elétrica, Florianópolis, 2013.Este trabalho objetiva a preparação de um arranjo experimental para o estudo da eletroporação de ...
Chiea, Rafael Attili
core  

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

Animal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source

Design and Construction of a Programmable Electroporation system for Biological Applications

, 2007
Studies into electroporation have grown rapidly in biotechnology and medicine in recent years. This paper presents the design and construction of a low cost programmable electroporation system for biological applications. The system consists of a control
Beeby, Steve, Rodamporn, Somphop, Chad, John, Harris, Nick, Brown, Andrew   +4 more
core   +1 more source

Combination of irreversible and calcium electroporation to overcome heterogeneity-associated incomplete ablation in the pancreas

Scientific Reports
Irreversible electroporation (IRE) can be considered as an alternative therapy for pancreatic tumors. However, a previous study revealed that the difference in electrical conductivity between the liver parenchyma and vessels was reported to result in ...
Min-Jung Ko, Hun-Young Yoon
doaj   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

Chapter Irreversible electroporation in pancreatic cancer [PDF]

, 2018
Pancreatic cancer is the deadliest of the gastrointestinal tract with 5-year survival rates of less than 5%. Given common asymptomatic early disease course, most patients (50%) present with an already metastatic disease, while only 20% can undergo ...
Gloor, Beat, Holzgang, Melanie, Erdem, Suna, Worni, Mathias, Eigl, Benjamin   +4 more
core   +1 more source