Results 71 to 80 of about 20,608 (192)

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Improving Prediction of the Potential Distribution Induced by Cylindrical Electrodes within a Homogeneous Rectangular Grid during Irreversible Electroporation

Applied Sciences, 2022
Background: Irreversible electroporation (IRE) is an ablation technique based on the application of short, high-voltage pulses between needle electrodes (diameter: ~1.0 × 10−3 m). A Finite Difference-based software simulating IRE treatment generally uses
Pierre Agnass, Krijn P. van Lienden, Thomas M. van Gulik, Marc G. Besselink, Johannes Crezee, H. Petra Kok   +5 more
doaj   +1 more source

Cell-Penetrating Peptides, Electroporation, and Drug Delivery

, 2010
Certain short polycations, such as TAT and oligoarginine, rapidly pass through the plasma membranes of mammalian cells by a mechanism called transduction, as well as by endocytosis and macropinocytosis.
Cahill, Kevin
core   +1 more source

Specific CT 3D rendering of the treatment zone after Irreversible Electroporation (IRE) in a pig liver model: the “Chebyshev Center Concept” to define the maximum treatable tumor size [PDF]

, 2014
Background: Size and shape of the treatment zone after Irreversible electroporation (IRE) can be difficult to depict due to the use of multiple applicators with complex spatial configuration.
Bellemann, Nadine, Fritz, Stefan, Gnutzmann, Daniel, Kauczor, Hans U., Knapp, Jürgen, Pereira, Philippe L., Radeleff, Boris A., Schmitz, Anne, Sommer, Christof M., Stampfl, Ulrike, Vollherbst, Dominik, Wachter, Miguel F., Werner, Jens, Wolf, Maya B, Zelzer, Sascha   +14 more
core   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Irreversible electroporation for prostate cancer using PSMA PET-CT

Prostate International, 2023
Background: To demonstrate the clinical usefulness of prostate-specific membrane antigen (PSMA) positron emission tomography (PET) computerized tomography (CT) for irreversible electroporation (IRE) in prostate cancer patients.
Dongho Shin, Chang Eil Yoon, Hyeok Jae Kwon, Hyong Woo Moon, Yong Hyun Park, Hyuk Jin Cho, U-syn Ha, Sung-Hoo Hong, Sonya Youngju Park, Seunggyun Ha, Joo Hyun O, Ie Ryung Yoo, Chansoo Park, Dae Yoon Chi, Ji Youl Lee   +14 more
doaj   +1 more source

Simple Model of the Transduction of Cell-Penetrating Peptides

, 2010
Cell-penetrating peptides (CPPs) such as HIV's trans-activating transcriptional activator (TAT) and polyarginine rapidly pass through the plasma membranes of mammalian cells by an unknown mechanism called transduction.
Andrews, Bevers, Chen, Datta, Dom, Duchardt, Fischer, Frankel, Grandmaison, Green, Haase, Harbour, Herce, Hosotani, Jiang, K. Cahill, Kuge, Lipinski, Mai, Melikov, Mendoza, O'Shaughnessy, Parsegian, Prochiantz, Rostovtseva, Rothbard, Rothbard, Saito, Snyder, Snyder, Stone, Tang, Tünnemann, Tünnemann, Tünnemann, Tyagi, Voelker, Wadia, Willam, Zhou, Ziegler   +40 more
core   +1 more source

The Faraday Scalpel: Electrochemical Nerve Lesioning Mechanisms Studied in Invertebrate Models

Advanced Science, EarlyView.
Direct‐current produces nerve lesioning through discrete electrochemical reactions. Using hypoxia‐sensitive locust nerves and hypoxia‐tolerant leech nerves, we map three injury pathways: cathodic oxygen reduction, cathodic alkalization, and anodic chloride oxidation. These findings establish electrochemical lesioning—the “Faraday Scalpel”—as a precise,
Petra Ondráčková, Jan Švec, Marie Jakešová, Jiří Ehlich, Imrich Gablech, Eric Daniel Głowacki   +5 more
wiley   +1 more source

Concurrently Achieving 4.6 W/M2 and 120,000 Cyclability Enabled by Extendable Swing Arms in Rotational Triboelectric Nanogenerator

Advanced Science, EarlyView.
A rotational energy harvesting device that successfully reconciles high power density with mechanical durability through a hybrid sliding‐and‐bouncing kinematic mechanism is reported. The success reported in our paper includes addressing a dilemma where enhanced electrical output comes at the cost of increased friction and wear, limiting the practical ...
Yihong Lin, Jiaming Zhou, In‐Yong Suh, Eunjong Kim, Kin Chiu Yip, Dae‐jin Kim, Jang‐Mook Jeong, Young‐Jun Kim, Jinyoung Jeon, Ju‐Hyuck Lee, Yoon‐Hwae Hwang, Sang‐Woo Kim, Dong‐Myeong Shin   +12 more
wiley   +1 more source

Illuminating the Intracellular World: Breakthroughs in Nanoscale Optoelectronics

Advanced Electronic Materials, EarlyView.
This perspective explores optoelectronic biointerfaces spanning macroscale flexible devices to nanoscale intracellular systems, emphasizing their integration across dimensions. It examines capacitive, Faradaic, and photothermal mechanisms that enable light‐driven control of cellular activity and highlights key material and design challenges in ...
Tania Assaf, Menahem Y. Rotenberg
wiley   +1 more source