Results 51 to 60 of about 20,608 (192)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

A statistical model describing combined irreversible electroporation and electroporation-induced blood-brain barrier disruption

Radiology and Oncology, 2016
Electroporation-based therapies such as electrochemotherapy (ECT) and irreversible electroporation (IRE) are emerging as promising tools for treatment of tumors.
Sharabi Shirley, Kos Bor, Last David, Guez David, Daniels Dianne, Harnof Sagi, Mardor Yael, Miklavcic Damijan   +7 more
doaj   +1 more source

Immunological effect of irreversible electroporation on hepatocellular carcinoma

BMC Cancer, 2021
Background This study intends to investigate the immunological effects of tumor ablation with irreversible electroporation (IRE). Methods We evaluated the systemic immune response in patients with hepatocellular carcinoma (HCC) after IRE treatment ...
Xiaoxia Guo, Fang Du, Qin Liu, Yan Guo, Qingbing Wang, Wei Huang, Zhongmin Wang, Xiaoyi Ding, Zhiyuan Wu   +8 more
doaj   +1 more source

A Study on Nonthermal Irreversible Electroporation of the Thyroid. [PDF]

, 2019
BackgroundNonthermal irreversible electroporation is a minimally invasive surgery technology that employs high and brief electric fields to ablate undesirable tissues.
Huang, Jianwei, Lv, Yanpeng, Rubinsky, Boris, Wang, Yunlong, Zhang, Yanfang   +4 more
core  

Initial assessment of safety and clinical feasibility of irreversible electroporation in the focal treatment of prostate cancer. [PDF]

, 2014
BACKGROUND: To evaluate the safety and clinical feasibility of focal irreversible electroporation (IRE) of the prostate. METHODS: We assessed the toxicity profile and functional outcomes of consecutive patients undergoing focal IRE for localised prostate
Ahmed, H.U., Allen, C., Dickinson, L., Emberton, M., Ponsky, L., Shnier, R., Stricker, P.D., Valerio, M.   +7 more
core   +2 more sources

Context‐Dependent Role of GDF15: GDF15+ Tumor‐Associated Macrophages Suppress OSCC Progression by Enhancing Phagocytosis

Advanced Science, EarlyView.
This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.
Xinyu Zhou, Zhihang Zhou, Houyu Ju, Chaoyang Guo, Fangxing Zhu, Yiyi Zhang, Xu Chen, Tongchao Zhao, Laiping Zhong, Jingzhou Hu   +9 more
wiley   +1 more source

Research Progress on the Application of Irreversible Electroporation Ablation in Cancers [PDF]

Advanced Ultrasound in Diagnosis and Therapy
Irreversible electroporation (IRE) is an innovative non-thermal ablation technique increasingly utilized in cancer treatment due to its unique operational principles and clinical advantages.
Zhang Rong, Xie Liting, Jin Qijing, Zhang Chengyue, Guo Teng, Zhao Qiyu, Jiang Tian’an
doaj   +1 more source

Rat liver regeneration following ablation with irreversible electroporation [PDF]

PeerJ, 2016
During the past decade, irreversible electroporation (IRE) ablation has emerged as a promising tool for the treatment of multiple diseases including hepatic cancer.
Alexander Golberg, Bote G. Bruinsma, Maria Jaramillo, Martin L. Yarmush, Basak E. Uygun   +4 more
doaj   +2 more sources

Sequential Irreversible Electroporation for Locally Advanced Pancreatic Cancer

Diagnostics, 2023
Pancreatic cancer is a lethal disease, with locally advanced pancreatic cancer (LAPC) having a dismal prognosis. For patients with LAPC, gemcitabine-based regimens, with or without radiation, have long been the standard of care.
Daniel Yuxuan Ong, Uei Pua
doaj   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source