Results 51 to 60 of about 195,259 (227)

NCLX Inhibition plus Ca2+ Delivery Potentiates Electroporation and Antitumor Immunity in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Electroporation combined with NCLX inhibition and Ca2+ delivery induces mitochondrial Ca2+ overload in PDAC cells, triggering pyroptosis, DAMP release, and antitumor immune activation. Simultaneously, suppression of tumor‐derived SPP1 weakens SPP1–CD44 signaling and remodels macrophages toward an antitumor phenotype, thereby enhancing CD8+ T‐cell ...
Chuanbing Zhao, Long He, Yu Lu, Zanglong Deng, Hongzhen Wei, Yunpeng Zhang, Ming Yang, Tao Yin   +7 more
wiley   +1 more source

Irreversible Electroporation of Liver Tumors

, 2017
The liver is a well-known site for tumors of benign as well as malignant origin. In the Western world, the most frequent hepatic malignancies encountered are liver metastases, especially but not solely from colorectal origin. Primary liver tumors, or the hepatocellular carcinoma (HCC), more frequently develop in people from Asian and Mediterranean ...
Nielsen, Karin, Scheffer, Hester J., Petrousjka van den Tol, M., Nilsson, Anders   +3 more
openaire   +2 more sources

Irreversible Electroporation for Inferior Turbinate Reduction Ablation in Adults

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Inferior turbinate hypertrophy is a common cause of nasal airway obstruction. An optimal surgical approach should provide effective volume reduction while preserving mucosal integrity and minimizing postoperative morbidity. Objective To evaluate the safety and efficacy of irreversible electroporation (IRE) for non‐thermal ablation ...
Narin Nard Carmel Neiderman, Codrut Sarafoleanu, Ionut Tanase, Mihai Alexandru Pascu, Desiderio Passali, Ulugbek Saidakramovich Khasanov, Ulugbek Nuridinovich Vokhidov, Eugenijus Lesinskas, Marius Polianskis, Avraham Abergel   +9 more
wiley   +1 more source

Preliminary study of steep pulse irreversible electroporation technology in human large cell lung cancer cell lines L9981 [PDF]

Archives of Biological Sciences, 2013
Our aim was to validate the effectiveness of steep pulse irreversible electroporation technology in human large cell lung cancer cells and to screen the optimal treatment of parameters for human large cell lung cancer cells.
Song Zuoqing, Pan Zhenhua, Xu Xiaohong, Wang Weiqiang, Zu Lingling, Wang Jing, Song Zhitao, Liu Hongyu, Li Zhigang, Li Chengxiang, Chen Jun, Yao Chenguo, Zhou Qinghua   +12 more
doaj   +1 more source

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

Animal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source

A statistical model describing combined irreversible electroporation and electroporation-induced blood-brain barrier disruption

Radiology and Oncology, 2016
Electroporation-based therapies such as electrochemotherapy (ECT) and irreversible electroporation (IRE) are emerging as promising tools for treatment of tumors.
Sharabi Shirley, Kos Bor, Last David, Guez David, Daniels Dianne, Harnof Sagi, Mardor Yael, Miklavcic Damijan   +7 more
doaj   +1 more source

The effects of irreversible electroporation (IRE) on nerves. [PDF]

PLoS ONE, 2011
BACKGROUND: If a critical nerve is circumferentially involved with tumor, radical surgery intended to cure the cancer must sacrifice the nerve. Loss of critical nerves may lead to serious consequences. In spite of the impressive technical advancements in
Wei Li, Qingyu Fan, Zhenwei Ji, Xiuchun Qiu, Zhao Li   +4 more
doaj   +1 more source

Irreversible electroporation for the treatment of cardiac arrhythmias [PDF]

Expert Review of Cardiovascular Therapy, 2018
Cardiac ablation is an established treatment modality for the management of patients with cardiac arrhythmias. Current approaches to cardiac ablation employ thermal based energy to achieve lesions (damage) within the heart. There are many shortcomings and limitations of thermal based approaches.
Sugrue, Alan, Maor, Elad, Ivorra Cano, Antoni, 1974-, Vaidya, Vaibhav, Witt, Chance, Kapa, Suraj, Asirvatham, Samuel   +6 more
openaire   +3 more sources

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

Research Progress on the Application of Irreversible Electroporation Ablation in Cancers [PDF]

Advanced Ultrasound in Diagnosis and Therapy
Irreversible electroporation (IRE) is an innovative non-thermal ablation technique increasingly utilized in cancer treatment due to its unique operational principles and clinical advantages.
Zhang Rong, Xie Liting, Jin Qijing, Zhang Chengyue, Guo Teng, Zhao Qiyu, Jiang Tian’an
doaj   +1 more source