Results 61 to 70 of about 10,834 (232)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Irreversible electroporation for the treatment of cardiac arrhythmias [PDF]

Expert Review of Cardiovascular Therapy, 2018
Cardiac ablation is an established treatment modality for the management of patients with cardiac arrhythmias. Current approaches to cardiac ablation employ thermal based energy to achieve lesions (damage) within the heart. There are many shortcomings and limitations of thermal based approaches.
Sugrue, Alan, Maor, Elad, Ivorra Cano, Antoni, 1974-, Vaidya, Vaibhav, Witt, Chance, Kapa, Suraj, Asirvatham, Samuel   +6 more
openaire   +3 more sources

Research Progress on the Application of Irreversible Electroporation Ablation in Cancers [PDF]

Advanced Ultrasound in Diagnosis and Therapy
Irreversible electroporation (IRE) is an innovative non-thermal ablation technique increasingly utilized in cancer treatment due to its unique operational principles and clinical advantages.
Zhang Rong, Xie Liting, Jin Qijing, Zhang Chengyue, Guo Teng, Zhao Qiyu, Jiang Tian’an
doaj   +1 more source

Immunologic response to tumor ablation with irreversible electroporation. [PDF]

PLoS ONE, 2012
BACKGROUND: Irreversible electroporation (IRE) is a promising technique for the focal treatment of pathologic tissues, which involves placing minimally invasive electrodes within the targeted region.
Xiaoxiang Li, Kui Xu, Wei Li, Xiuchun Qiu, Baoan Ma, Qingyu Fan, Zhao Li   +6 more
doaj   +1 more source

Sequential Irreversible Electroporation for Locally Advanced Pancreatic Cancer

Diagnostics, 2023
Pancreatic cancer is a lethal disease, with locally advanced pancreatic cancer (LAPC) having a dismal prognosis. For patients with LAPC, gemcitabine-based regimens, with or without radiation, have long been the standard of care.
Daniel Yuxuan Ong, Uei Pua
doaj   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

An update on irreversible electroporation of liver tumours [PDF]

Hong Kong Medical Journal, 2014
OBJECTIVE. To investigate the clinical efficacy and safety of irreversible electroporation for ablation of liver tumour in humans. DATA SOURCES. The PubMed and MEDLINE databases were systematically searched. STUDY SELECTION. Clinical research published in English in the last 10 years until October 2013 that address clinical issues related to ...
Wong, K, Yeung, ESL, So, ECT, Chan, ACY, Wong, CYK, Chung, MWY   +5 more
openaire   +4 more sources

Immunological effect of irreversible electroporation on hepatocellular carcinoma

BMC Cancer, 2021
Background This study intends to investigate the immunological effects of tumor ablation with irreversible electroporation (IRE). Methods We evaluated the systemic immune response in patients with hepatocellular carcinoma (HCC) after IRE treatment ...
Xiaoxia Guo, Fang Du, Qin Liu, Yan Guo, Qingbing Wang, Wei Huang, Zhongmin Wang, Xiaoyi Ding, Zhiyuan Wu   +8 more
doaj   +1 more source

Clinical course following irreversible electroporation (IRE).

, 2016
Clinical course following irreversible electroporation (IRE).
Jianhua Zhang (6347), Wenlong Zhang (283123), Wei Chai (403946), Kecheng Xu (3373754), Jiuping Wu (3373748), Xulong Zhou (3373757), Xiaomei Luo (502040), Jian Shi (141852), Jianying Zeng (3373751), Lizhi Niu (3373745), Xianjun Liang (3373760), Jiannan Li (1505440), Shuai Guo (1353816), Gang Fang (11785)   +13 more
core   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source