Results 61 to 70 of about 182,783 (241)

TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains

Advanced Science, EarlyView.
Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang, Xiao Wang, Hongyan Ma, Pengcheng Lyu, Shuangjie Tian, Ruojun Zong, Jiani Chen, Gang Ren, Yongjiang Yang, Zichen Yang, Guosong Qin, Naishi Li, Yanfang Wang, Jianwei Jiao, Jianguo Zhao   +14 more
wiley   +1 more source

Immunological effect of irreversible electroporation on hepatocellular carcinoma

BMC Cancer, 2021
Background This study intends to investigate the immunological effects of tumor ablation with irreversible electroporation (IRE). Methods We evaluated the systemic immune response in patients with hepatocellular carcinoma (HCC) after IRE treatment ...
Xiaoxia Guo, Fang Du, Qin Liu, Yan Guo, Qingbing Wang, Wei Huang, Zhongmin Wang, Xiaoyi Ding, Zhiyuan Wu   +8 more
doaj   +1 more source

Sequential Irreversible Electroporation for Locally Advanced Pancreatic Cancer

Diagnostics, 2023
Pancreatic cancer is a lethal disease, with locally advanced pancreatic cancer (LAPC) having a dismal prognosis. For patients with LAPC, gemcitabine-based regimens, with or without radiation, have long been the standard of care.
Daniel Yuxuan Ong, Uei Pua
doaj   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Research Progress on the Application of Irreversible Electroporation Ablation in Cancers [PDF]

Advanced Ultrasound in Diagnosis and Therapy
Irreversible electroporation (IRE) is an innovative non-thermal ablation technique increasingly utilized in cancer treatment due to its unique operational principles and clinical advantages.
Zhang Rong, Xie Liting, Jin Qijing, Zhang Chengyue, Guo Teng, Zhao Qiyu, Jiang Tian’an
doaj   +1 more source

Rat liver regeneration following ablation with irreversible electroporation [PDF]

PeerJ, 2016
During the past decade, irreversible electroporation (IRE) ablation has emerged as a promising tool for the treatment of multiple diseases including hepatic cancer.
Alexander Golberg, Bote G. Bruinsma, Maria Jaramillo, Martin L. Yarmush, Basak E. Uygun   +4 more
doaj   +2 more sources

Irreversible electroporation for the treatment of cardiac arrhythmias [PDF]

Expert Review of Cardiovascular Therapy, 2018
Cardiac ablation is an established treatment modality for the management of patients with cardiac arrhythmias. Current approaches to cardiac ablation employ thermal based energy to achieve lesions (damage) within the heart. There are many shortcomings and limitations of thermal based approaches.
Sugrue, Alan, Maor, Elad, Ivorra Cano, Antoni, 1974-, Vaidya, Vaibhav, Witt, Chance, Kapa, Suraj, Asirvatham, Samuel   +6 more
openaire   +3 more sources

Clinical course following irreversible electroporation (IRE).

, 2016
Clinical course following irreversible electroporation (IRE).
Jianhua Zhang (6347), Wenlong Zhang (283123), Wei Chai (403946), Kecheng Xu (3373754), Jiuping Wu (3373748), Xulong Zhou (3373757), Xiaomei Luo (502040), Jian Shi (141852), Jianying Zeng (3373751), Lizhi Niu (3373745), Xianjun Liang (3373760), Jiannan Li (1505440), Shuai Guo (1353816), Gang Fang (11785)   +13 more
core   +1 more source

Model of cell electrofusion Membrane electroporation, pore coalescence and percolation [PDF]

, 1987
Sugar IP, Förster W, Neumann E. Model of cell electrofusion Membrane electroporation, pore coalescence and percolation. Biophysical Chemistry.
Förster, Walter, Istvan P. Sugar, Eberhard Neumann, Sugar, Istvan P., Walter Förster, Neumann, Eberhard   +5 more
core   +1 more source

CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome

Advanced Science, EarlyView.
By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen, Zhiquan Liu, Wenmin Wang, Qing Wang, Tia J. Kowal, Fan Zhang, Grzegorz Walkiewicz, Faruk Hossen, Herbert M. Lachman, Jinqiong Zhou, Yiting Wang, Yang Sun   +11 more
wiley   +1 more source