Results 111 to 120 of about 182,783 (241)

A characterization of the reversibly electroporated penumbra during irreversible electroporation

Cancer Treatment and Research Communications
Irreversible electroporation (IRE) is a novel anticancer ablative treatment, which has been proposed to enhance the efficacy of chemotherapy in the periphery of the ablated area by capturing chemotherapy intracellularly. The aim of the current trial was to characterize the ablated lesion to get spatial information about the distribution of captured ...
Rasmus Virenfeldt Flak, Jonatan Riber Granborg, Christian Janfelt, Martin Skovmos Nielsen, Benedict Kjærgaard, Ole Thorlacius-Ussing   +5 more
openaire   +3 more sources

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

A live‐cell autophagy reporter reveals reversible vacuolation in naked mole‐rat skin fibroblasts under lysosomal stress

The FEBS Journal, EarlyView.
A tandem fluorescent mCherry–EGFP–LC3 reporter enables live‐cell visualisation of autophagy–lysosome dynamics in naked mole‐rat skin fibroblasts. Chloroquine‐induced lysosomal stress promotes accumulation of neutral LC3‐positive compartments and triggers pronounced LC3‐associated vacuolation.
Fangze Tong, Mateo P. Hoare, Laura J. Grundy, Filomena Gallo, Karin H. Müller, Ewan St. John Smith, Janet R. Kumita   +6 more
wiley   +1 more source

Catheter Ablation: Evolution and Efficiencies

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT The present review includes a discussion the goals and pitfalls of efficiency in the medical profession, a historical perspective on the evolution of catheter ablation in the field of electrophysiology (EP), and the data regarding the relationship between efficiency and outcomes in the EP lab. Focus on efficacy is critical to maximize resource
Aravind G. Kalluri, Bradley P. Knight
wiley   +1 more source

166 Radiation Therapy and IRreversible Electroporation (RTIRE) for Intermediate Risk Prostate Cancer

Journal of Clinical and Translational Science
OBJECTIVES/GOALS: Prostate cancer treatment is associated with significant genitourinary side effects. There is a critical need for treatment with decreased morbidity.
Timothy McClure, Francesca Khani, Brian Robinson, Ariel E Marciscano, Christopher Barbieri, Joseph Osborne, Himanshu Nagar   +6 more
doaj   +1 more source

Feasibility, Safety, and Efficacy of Pulsed Field Ablation for Ventricular Arrhythmias: Insights From a Large Health System Registry in the United States

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background Pulsed field ablation (PFA) is an emerging non‐thermal ablation modality with proven safety in atrial arrhythmia ablation. However, data on its performance for ventricular arrhythmias (VA) remain limited. Objective To evaluate the feasibility, safety, and efficacy of PFA for complex VA in a multicenter real‐world US registry ...
Narut Prasitlumkum, Juan F. Rodriguez‐Riascos, Hema Vemulapalli, Aakash Somappa, Camilo A. Estrada‐Vargas, Olubadewa A. Fatunde, Carlos A. Rojas, Poojan Prajapati, Keerthika Vijayakumar, Suraj Kapa, Duy Nguyen, Samuel Asirvatham, Malini Madhavan, Christopher McLeod, Hicham Z. El Masry, Abhishek J. Deshmukh, Danesh K. Kella, Ammar M. Killu, Siva K. Mulpuru, Mayank Sardana, Luis R. Scott, Alan M. Sugrue, Komandoor Srivathsan   +22 more
wiley   +1 more source

Power-Driven Electroporation Is Predictive of Treatment Outcomes in a Conductivity-Independent Manner

BME Frontiers
Objective: This study characterizes the effects of external conductivity on electroporation to develop methods to overcome potential patient-to-patient variability.
Edward J. Jacobs, Julio P. Arroyo, Manali Powar, Pedro P. Santos, Irving Allen, Rafael Davalos   +5 more
doaj   +1 more source

Cryoballoon Versus Radiofrequency Ablation for Persistent Atrial Fibrillation: Meta‐Analysis of Randomized Trials

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Introduction Pulmonary vein isolation (PVI) alone achieves modest arrhythmia freedom in persistent atrial fibrillation (PeAF). Cryoballoon ablation (CBA) offers a single‐shot alternative to radiofrequency ablation (RFA) that streamlines procedural workflow.
Harroop Bola, Aksaan Arif, Joshua J. Hon, Gayathri Giritharan, Prachur Khandelwal, Rodrick Avakian, Amar Rai, Kiran Haresh Kumar Patel, Fu Siong Ng   +8 more
wiley   +1 more source

Effects of Irreversible Electroporation and High-Frequency Irreversible Electroporation for the Treatment of Breast Cancer

, 2023
Breast cancer (BC) is the second most common cause of cancer-related deaths for women in the United States, estimated to affect 1 in 8 women. Difficulties arise in BC treatment due to the hormone sensitivity and heterogeneity of the malignancies, and the
Saunier, Sofie Milou
core  

Knocking Out Two Polyphenol Oxidase Genes Significantly Improves Recombinant Protein Purification in Nicotiana benthamiana

Plant Biotechnology Journal, EarlyView.
ABSTRACT Efficient purification remains a key technical challenge affecting the recovery efficiency of recombinant proteins in plant‐based systems. Complex metabolites, particularly polyphenols, often cause recombinant protein aggregation during purification.
Hai‐Ping Diao, Hui‐Xin Meng, Xue‐Jiao Xu, Zeng‐Lin Zhang, Jian‐Feng Zhang, Yong‐Feng Guo, Inhwan Hwang, Shi‐Jian Song   +7 more
wiley   +1 more source