Results 131 to 140 of about 182,783 (241)
ABSTRACT High‐fat diet (HFD)‐induced hepatic injury represents a pathology observed across vertebrates, yet the underlying mechanisms remain incompletely understood. Herein, the present study identifies phosphatidylethanolamine methyltransferase (Pemt), a key enzyme in phosphatidylcholine synthesis, as a critical regulator of mitochondrial homeostasis ...
Xianyong Bu +11 more
wiley +1 more source
Salvage prostate therapies for local pelvic recurrence after primary radiation for prostate cancer
Abstract Objectives The purpose of this study is to evaluate salvage treatment after primary radiation therapy (RT) for prostate cancer within our hospital system. Specifically, we aim to evaluate treatment patterns, oncologic outcomes and complications.
Jamie Michael +9 more
wiley +1 more source
ABSTRACT Balloon‐assisted transseptal puncture across a large atrial septal defect closure device can permit pulsed‐field ablation in selected patients with complex septal anatomy, achieving durable pulmonary vein isolation and sinus rhythm. A borderline residual left‐to‐right shunt developed post‐procedure but decreased on serial imaging without ...
Ahmed Abdelrazik +5 more
wiley +1 more source
This meta‐analysis compared pentaspline PFA and cryoballoon ablation for AF. PFA shortened procedure time, reduced phrenic nerve injury, and lowered arrhythmia recurrence in paroxysmal AF despite elevated troponin release. ABSTRACT Background Pulsed‐field ablation (PFA) is an emerging technology for atrial fibrillation (AF) ablation.
Yi Cai +3 more
wiley +1 more source
This review demonstrates essential quality assessment metrics for monitoring product stability and identifying the major causes of post‐harvest deterioration of seaweed. It evaluates common and advanced preservation techniques for their ability to extend shelf life while maintaining nutritional value, microbiological safety, and sensory quality.
Shanjida Islam Shikha +2 more
wiley +1 more source
Lithium for rechargeable batteries is increasingly extracted from brines in high‐Andean salars. Direct Lithium Extraction (DLE) technologies are promoted as sustainable alternatives to conventional evaporation ponds. This work explores how brine modification and reinjection may affect microbial communities and ecosystem functioning, highlighting the ...
Carolina F. Cubillos +2 more
wiley +1 more source
Engineering Extracellular Vesicles: Strategies for Functional Modification and Clinical Translation
The engineering modification strategies of extracellular vesicles (EVs). This figure presents the four core technical systems for the engineering modification of EVs, including direct modification strategies (physical and chemical methods), biological engineering methods, and hybrid and bionic strategies.
Zhouming Cheng +3 more
wiley +1 more source
Smart Design: Integrating Artificial Intelligence and Gene Editing for Advanced mRNA Therapeutics
The challenges of mRNA therapy and the application of artificial intelligence and gene editing in the field of mRNA drugs. ABSTRACT Artificial intelligence (AI) and gene editing are increasingly being applied to the design and evaluation of mRNA therapeutics.
Haixing Shi +11 more
wiley +1 more source
Abscopal Effect in Radiation Therapy: The Immune Mechanisms and Clinical Advances
The schematic outlines the key events of the abscopal effect. (Ignition) Local radiotherapy (RT) induces the release of immunogenic signals from the tumor, leading to dendritic cell (DC) activation. (Orchestration) In the tumor‐draining lymph node (TDLN), DCs prime naive T cells into cytotoxic T lymphocytes (CTLs), a process modulated by regulatory T ...
Yihong Dong +5 more
wiley +1 more source
Avoiding nerve stimulation in irreversible electroporation: a numerical modeling study
Electroporation based treatments consist in applying one or multiple high voltage pulses to the tissues to be treated. As an undesired side effect, these pulses cause electrical stimulation of excitable tissues such as nerves and muscles.
Mercadal, Borja +7 more
core +1 more source

