Results 131 to 140 of about 4,322 (180)
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The Antibacterial Activity of Isatin Hybrids
Current Topics in Medicinal Chemistry, 2022Abstract:Bacterial infections, which cause a wide range of host immune disorders leading to local and systemic tissue damage, are still one of the main causes of patient morbidity and mortality worldwide. Treatment of bacterial infections is challenging, mainly attributed to the rapidly evolving resistance mechanisms, creating an urgent demand to ...
Bi, Liu, Dan, Jiang, Guowen, Hu
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Isatin‐1,2,3‐triazole‐isatin Scaffolds and Their Antibacterial Activity
Journal of Heterocyclic Chemistry, 2019Twelve novel isatin‐1,2,3‐triazole‐isatin scaffolds 5a–l were designed, synthesized, and assessed for their in vitro antibacterial activity in this paper. The preliminary results showed that all dimers only endowed with weak antibacterial activity, which was less active than the reference ciprofloxacin.
Ruijing Cheng, Xinjia Yan, Zhi Xu
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Chemistry – An Asian Journal, 2020
AbstractA general method for the construction of trifluoromethylated 2‐quinolinones has been established herein by using a trifluoromethylative ring expansion of isatin with trifluorodiazoethane. The strategy provides a platform for the rapid synthesis of a wide range of substituted 3‐hydroxy‐4‐trifluoromethyl‐2‐quinolinones.
Muhammad Fahad Jamali +4 more
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AbstractA general method for the construction of trifluoromethylated 2‐quinolinones has been established herein by using a trifluoromethylative ring expansion of isatin with trifluorodiazoethane. The strategy provides a platform for the rapid synthesis of a wide range of substituted 3‐hydroxy‐4‐trifluoromethyl‐2‐quinolinones.
Muhammad Fahad Jamali +4 more
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Isatin Hybrids and Their Pharmacological Investigations
Mini-Reviews in Medicinal Chemistry, 2021Hybridization is an important strategy to design molecules that can be effectively used to treat fatal diseases known to mankind. Molecular hybrids and their pharmacological investigations aided in discovering several potent isatin (Indole 2, 3 dione) derivatives with anti-HIV, antimalarial, antitubercular, antibacterial, and anticancer activities ...
Bhushan D. Varpe +4 more
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Isatin: A Scaffold with Immense Biodiversity
Mini-Reviews in Medicinal Chemistry, 2021Isatin is an endogenous and a significant category of fused heterocyclic components and has widely been a part of several potential biologically useful synthetics. Since its discovery, tons of research work has been conducted with respect to the synthesis, chemical properties, and biological and industrial applications.
Priyobrata Nath +5 more
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The loss of CO and HCN in the fragmentation of isatin and the methyl isatins
Organic Mass Spectrometry, 1971Abstract3‐13C‐Isatin has been shown to eliminate the 2‐carbonyl group as the initial fragment, followed predominantly by loss of HCN. In 4‐, 5‐and 6‐methyl‐isatin the loss of the second carbonyl group competes evenly with HCN loss, whilst the 7‐methyl isomer fragments almost exclusively by successive loss of two molecules of CO from the molecular ion.
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Reaction of Isatin with Thiocarbohydrazide: A Correction
Archiv der Pharmazie, 1991AbstractHeterocycles containing the indole ring system include some novel pharmacologically active compounds1–3). Isatin and its N‐acetylisatin are extremely versatile intermediates in the construction of a variety of heterocyclic systems when reacted with thiosemicarbazide derivatives.
M A, Badawy, S A, Abdel-Hady
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Reaction of ω-Vinyloxyalkylamines with Isatin
Russian Journal of Organic Chemistry, 20033-(ω-Vinyloxyalkylimino)-2,3-dihydroindol-2-ones and 3-(vinyloxyphenylimino)-2,3-dihydroindol-2-ones were synthesized in 34-93% yield by reactions of ω-aminoalkyl and aminophenyl vinyl ethers with isatin.
B. F. Kukharev +3 more
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Remote Activation of the Nucleophilicity of Isatin
Organic Letters, 2014The concept of the remote activation of reactivity was first applied in asymmetric organocatalysis. An isatin 3-phenylimine derivative acts as a donor in the thiourea catalyzed asymmetric addition to unsaturated 1,4-ketoesters, affording aza-Michael adducts in high enantiomeric purity and yield.
Sergei, Žari +4 more
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Reaction of (chloromethyl)thiirane with isatins
Russian Journal of Organic Chemistry, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A. N. Butkevich +3 more
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