Results 61 to 70 of about 258,774 (251)

Risk of Non‐Arteritic Anterior Ischemic Optic Neuropathy in Idiopathic Intracranial Hypertension Patients Treated with GLP‐1 Receptor Agonists

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have demonstrated significant weight‐reducing effects and may offer benefits in idiopathic intracranial hypertension (IIH); however, recent concerns about the risk of non‐arteritic anterior ischemic optic neuropathy (NAION) have emerged.
Faisal A. Al‐Harbi, Mohanad A. Alkuwaiti, Yazeed B. Alaql, Ahmed K. Alsaif, Ahmed A. Alessa, Meshari Ayed Alharbi, Mohammed Alfalah, Saud A. Alnaaim, Sajjad M. AlHaddad, Ahmed Y. Azzam   +9 more
wiley   +1 more source

PHD2 regulates arteriogenic macrophages through TIE2 signalling

EMBO Molecular Medicine, 2013
Occlusion of the main arterial route redirects blood flow to the collateral circulation. We previously reported that macrophages genetically modified to express low levels of prolyl hydroxylase domain protein 2 (PHD2) display an arteriogenic phenotype ...
Alexander Hamm, Lorenzo Veschini, Yukiji Takeda, Sandra Costa, Estelle Delamarre, Mario Leonardo Squadrito, Anne‐Theres Henze, Mathias Wenes, Jens Serneels, Ferdinando Pucci, Carmen Roncal, Andrey Anisimov, Kari Alitalo, Michele De Palma, Massimiliano Mazzone   +14 more
doaj   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Toll-Like Receptors in Ischaemia and Its Potential Role in the Pathophysiology of Muscle Damage in Critical Limb Ischaemia [PDF]

, 2012
Toll-like receptors (TLRs) are key receptors of the innate immune system which are expressed on immune and nonimmune cells. They are activated by both pathogen-associated molecular patterns and endogenous ligands.
Hemanshu Patel, Janice C. S. Tsui, Xu Shi-Wen, Shaw, SG, Shi-Wen, Xu, Abraham, David, Patel, H, Tsui, Janice C. S., Patel, Hemanshu, Baker, Daryll M., Tsui, JC, Sidney G. Shaw, Baker, DM, David Abraham, Shi-Wen, X, Abraham, D, Daryll M. Baker, Shaw, Sidney G.   +17 more
core   +2 more sources

Amphiregulin is overexpressed in human cardiac tissue in hypothermia deaths; associations between the transcript and stress hormone levels in cardiac deaths

Annals of Medicine
Background Amphiregulin (AREG) is a growth factor linked to cardioprotection and heart pathology during myocardial stress. Our aim was to investigate cardiac AREG expression, its potential as a postmortem hypothermia marker and its possible stress ...
Katja Porvari, Kie Horioka, Helena Kaija, Lasse Pakanen   +3 more
doaj   +1 more source

Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon, Hugues Chabriat, Dominique Hervé, Stéphanie Guey, Sophie Tezenas Du Montcel, Juliette Ortholand   +5 more
wiley   +1 more source

Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation [PDF]

, 2009
CsA (cyclosporin A) is a hydrophobic undecapeptide that inhibits CyPs (cyclophilins), a family of PPIases (peptidylprolyl cis–trans isomerases). In some experimental models, CsA offers partial protection against lethal cell injury brought about by ...
Crompton, M., Henry Dube, Malouitre, S., Sylvanie Malouitre, Selwood, D., Martin Crompton, Dube, H., David Selwood   +7 more
core   +1 more source

Delayed hypothermia prevents decreases in N-acetylaspartate and reduced glutathione in the cerebral cortex of the neonatal pig following transient hypoxia-ischaemia

, 2013
The effects of normothermia and delayed hypothermia on the levels of N-acetylaspartate (NAA), reduced glutathione (GSH) and the activities of mitochondrial complex I, II-III, IV and citrate synthase were measured in brain homogenates obtained from ...
Martina Noone (17251171), Yasuko Sakata (17251177), Ernest Cady (17251159), Keith J Brooks (17251165), Francis O'Brien (17251162), Iain Hargreaves (49266), Roger Ordidge (17185633), Quyen Nguyen (1312230), Matthew Clemence (17251174), Timothy Bates (17153641), John Thornton (539603), John Wyatt (233278), Kishore Bhakoo (7552550), Mark Sellwood (17251168), Marzena Wylezinska (2609704)   +14 more
core   +5 more sources

Neuroprotective Effect of Sweet Potato Petiole and Leaf Dry‐Powder in a Gerbil Model of Transient Cerebral Ischaemia

Veterinary Medicine and Science
Objectives This study aimed to investigate the neuroprotective effects of sweet potato petioles and leaves (PL), which are rich in polyphenols with antioxidant and anti‐inflammatory properties, using a gerbil model of transient cerebral ischaemia.
Kazuhisa Sugai, Asahi Oda, Yuka Maeda, Yuzuki Murakami, Masahiko Fujisawa, Masahiro Shibata, Toshiyuki Murakoshi, Shou Kobayashi, Hisanobu Hirano, Sadahiko Iwamoto, Eiji Kobayashi, Yoji Hakamata   +11 more
doaj   +1 more source

Acute ischaemia and gap junction modulation modify propagation patterns across Purkinje-myocardial junctions

Frontiers in Physiology
BackgroundThe Purkinje network is essential for normal electrical impulse propagation in the heart but has also been implicated in ventricular arrhythmias.
Richard J. Jabbour, Elham Behradfar, Elham Behradfar, Michael Debney, Anders Nygren, Anders Nygren, Adam Hartley, Igor Efimov, Mélèze Hocini, Mélèze Hocini, Nicholas S. Peters, Fu Siong Ng, Edward J. Vigmond, Edward J. Vigmond, Edward J. Vigmond   +14 more
doaj   +1 more source