Results 121 to 130 of about 1,336,017 (348)

Anti-inflammatory and antioxidant activity of essential amino acid α-ketoacid analogues against renal ischemia–reperfusion damage in Wistar rats

Biomédica: revista del Instituto Nacional de Salud, 2020
Introduction: Essential amino acid α-keto acid analogs are used in the treatment of chronic kidney disease to delay the symptoms of uremia. However, it is unknown whether essential amino acid α-keto acid analogs affect the oxidative stress and the ...
Concepción Sánchez-Martínez, Liliana Torres-González, Gabriela Alarcón-Galván, Linda E. Muñoz-Espinosa, Homero Zapata-Chavira, Diana Patricia Moreno-Peña, Homero Náñez-Terreros, Edelmiro Pérez-Rodríguez, Lourdes Garza-Ocañas, Francisco Javier Guzmán-de la Garza, Paula Andrea Cordero   +10 more
doaj   +1 more source

Ischemia/Reperfusion Injury Revisited: An Overview of the Latest Pharmacological Strategies

International Journal of Molecular Sciences, 2019
Ischemia/reperfusion injury (IRI) permeates a variety of diseases and is a ubiquitous concern in every transplantation proceeding, from whole organs to modest grafts.
Ricardo O S Soares, D. M. Losada, M. C. Jordani, P. R. B. Évora, O. Castro-e-Silva   +4 more
semanticscholar   +1 more source

Therapeutic modulation of liver ischaemia reperfusion injury [PDF]

, 2011
Liver Ischaemia Reperfusion Injury (IRI) leads to production of reactive oxygen species and cytokines, which affects hepatocellular function following liver resection and transplantation.
Sheth, H.
core  

Prolonged low flow reduces reactive hyperemia and augments low flow mediated constriction in the brachial artery independent of the menstrual cycle [PDF]

, 2013
© 2013 Rakobowchuk et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Gibbins, Sarah E., Birch, KM, Sarah E Gibbins, Mark Rakobowchuk, Parsloe, Emily R., Emma Harris, Birch, Karen M., Parsloe, ER, Harris Emma, Gibbins, SE, Rakobowchuk Mark, Gibbins Sarah E., Harris, E, Rakobowchuk, Mark, Rakobowchuk, M, Parsloe Emily R., Birch Karen M., Karen M Birch, Harris, Emma, Emily R Parsloe   +19 more
core   +2 more sources

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Autophagy and Liver Ischemia-Reperfusion Injury [PDF]

BioMed Research International, 2015
Liver ischemia-reperfusion (I-R) injury occurs during liver resection, liver transplantation, and hemorrhagic shock. The main mode of liver cell death after warm and/or cold liver I-R is necrosis, but other modes of cell death, as apoptosis and autophagy, are also involved. Autophagy is an intracellular self-digesting pathway responsible for removal of
Raffaele Cursio, Pascal Colosetti, Jean Gugenheim   +2 more
openaire   +2 more sources

Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat [PDF]

, 2012
The main goal of adequate organ preservation is to avoid further cellular metabolism during the phase of ischemia. However, modern preservation solutions do rarely achieve this target.
Paulus, Patrick, Tacke Sabine, Johannes Holfeld, Karnowski Nora, Patrick Paulus, Holfeld, Johannes, Urbschat, Anja, Urbschat Anja, Zacharowski, Kai, Tacke, Sabine, Ockelmann, Pia, Nora Karnowski, Karnowski, Nora, Bertram Scheller, Scheller, Bertram, Pia Ockelmann, Ellinghaus, Peter, Paulus Patrick, Zacharowski Kai, Sabine Tacke, Ellinghaus Peter, Anja Urbschat, Kai Zacharowski, Peter Ellinghaus, Ockelmann Pia, Scheller Bertram, Holfeld Johannes   +26 more
core   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Salidroside Ameliorates Mitochondria-Dependent Neuronal Apoptosis after Spinal Cord Ischemia-Reperfusion Injury Partially through Inhibiting Oxidative Stress and Promoting Mitophagy

Oxidative Medicine and Cellular Longevity, 2020
Ischemia-reperfusion injury is the second most common injury of the spinal cord and has the risk of neurological dysfunction and paralysis, which can seriously affect patient quality of life. Salidroside (Sal) is an active ingredient extracted from Herba
Changjiang Gu, Lin-Wei Li, Yi-Fan Huang, Ding-Fei Qian, Wei Liu, Cheng-Liang Zhang, Yongjun Luo, Zheng Zhou, Fan-Qi Kong, Xuan Zhao, Hao Liu, Peng Gao, Jian Chen, Guo-Yong Yin   +13 more
semanticscholar   +1 more source

Postconditioning: a form of "modified reperfusion" protects the myocardium by activating the phosphatidylinositol 3-kinase-akt pathway [PDF]

, 2004
Brief intermittent episodes of ischemia and reperfusion, at the onset of reperfusion after a prolonged period of ischemia, confer cardioprotection, a phenomenon termed "ischemic postconditioning" (Postcond).
Tsang, A., Yellon, D.M., Hausenloy, D.J., Mocanu, M.M.   +3 more
core