Results 21 to 30 of about 1,043,947 (356)

FK 506 pre-treatment is associated with reduced levels of tumor necrosis factor and interleukin 6 following hepatic ischemia/reperfusion [PDF]

, 1993
Using a rat model, the effect of pre-treatment with FK 506 on hepatic ischemia/reperfusion injury was investigated. All control animals died within 72 h of the ischemia/reperfusion injury.
Aarden, Billiau, Camussi, Chollet-Martin, Colletti, Colletti, Craig J. McClain, David H. Van Thiel, Farber, Ferrante, Fischer, Francavilla, Francavilla, Gamble, Gauldie, Giorgio M. Zetti, Hajjar, Harding, Hayashi, Hishinuma, Honchel, Howard, Jirik, Judith S. Gavaler, Kahan, Kahn, Kawakani, Kim, Kim, Kino, Kishimoto, Kishimoto, Kramer, Lotz, Magilavy, Mahmoud F. Sakr, Makowka, Makowka, Matuschak, Maury, Mazzaferro, Meer, Miyahara, Mizel, Nagakawa, Nagakawa, Nawroth, Nordan, Nordan, Pennica, Perez-Tamayo, Pohlman, Sakai, Sakr, Shalaby, Shaw, Siekierka, Starzl, Starzl, Strieter, Takahashi, Thomas E. Starzl, Van Snick, Wankowicz, Yushimira   +64 more
core   +1 more source

NOX1 promotes myocardial fibrosis and cardiac dysfunction via activating the TLR2/NF-κB pathway in diabetic cardiomyopathy

Frontiers in Pharmacology, 2022
Diabetic cardiomyopathy (DCM) is a prevalent complication in patients with diabetes, resulting in high morbidity and mortality. However, the molecular mechanisms of diabetic cardiomyopathy have yet to be fully elucidated. In this study, we investigated a
Dandan Zhang, Dandan Zhang, Yilan Li, Yilan Li, Weijie Wang, Weijie Wang, Xueyan Lang, Xueyan Lang, Yanxiu Zhang, Yanxiu Zhang, Qianqian Zhao, Qianqian Zhao, Jingru Yan, Jingru Yan, Yao Zhang, Yao Zhang   +15 more
doaj   +1 more source

Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat [PDF]

, 2004
Results from several studies indicate that cyclooxygenase-2 (COX-2) is involved ischemic brain injury. The purpose of this study was to evaluate the neuroprotective effects of the selective COX-2 inhibitor nimesulide on cerebral infarction and ...
Candelario-Jalil, Eduardo, Fiebich, Bernd L., García-Cabrera, Michel, González-Falcón, Armando, León, Olga S.   +4 more
core   +1 more source

Persistent Cigarette Smoking Attenuates Plaque Stabilization in Response to Lipid-Lowering Therapy: A Serial Optical Coherence Tomography Study

Frontiers in Cardiovascular Medicine, 2021
Objective: This study aimed to investigate the effect of smoking on morphological changes in non-culprit plaques in acute coronary syndrome (ACS) patients at 1 year after percutaneous coronary intervention (PCI), using optical coherence tomography (OCT ...
Xiling Zhang, Xiling Zhang, Xiang Peng, Xiang Peng, Lulu Li, Lulu Li, Huai Yu, Huai Yu, Bo Yu, Bo Yu   +9 more
doaj   +1 more source

Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission. [PDF]

, 2017
Linoleic acid (LA; 18:2 n-6), the most abundant polyunsaturated fatty acid in the US diet, is a precursor to oxidized metabolites that have unknown roles in the brain.
Bazinet, Richard P, Hammock, Bruce D, Hennebelle, Marie, Kitson, Alex P, Lee, Kin Sing Stephen, Metherel, Adam H, Otoki, Yurika, Richardson, Christine E, Taha, Ameer Y, Yang, Jun, Zhang, Liang, Zhang, Zhichao   +11 more
core   +1 more source

Artificial Intelligence—A Good Assistant to Multi-Modality Imaging in Managing Acute Coronary Syndrome

Frontiers in Cardiovascular Medicine, 2022
Acute coronary syndrome is the leading cause of cardiac death and has a significant impact on patient prognosis. Early identification and proper management are key to ensuring better outcomes and have improved significantly with the development of ...
Ming-hao Liu, Ming-hao Liu, Chen Zhao, Chen Zhao, Shengfang Wang, Shengfang Wang, Haibo Jia, Haibo Jia, Bo Yu, Bo Yu   +9 more
doaj   +1 more source

Modulation of Mitochondrial Bioenergetics in the Isolated Guinea Pig Beating Heart by Potassium and Lidocaine Cardioplegia: Implications for Cardioprotection [PDF]

, 2009
Mitochondria are damaged by cardiac ischemia/reperfusion (I/R) injury but can contribute to cardioprotection. We tested if hyperkalemic cardioplegia (CP) and lidocaine (LID) differently modulate mitochondrial (m) bioenergetics and protect hearts against ...
Aldakkak, Mohammed, Camara, Amadou K.S., Chen, Qun, Heisner, James S., Lesnefsky, Edward J., Stowe, David F.   +5 more
core   +2 more sources

Non-culprit plaque characteristics in acute coronary syndrome patients with raised hemoglobinA1c: an intravascular optical coherence tomography study

Cardiovascular Diabetology, 2018
Background Raised hemoglobinA1c (HbA1c) is an indicator of pre-diabetes, which is associated with increased risk of coronary artery disease. However, the detailed morphological characteristics of non-culprit plaques in acute coronary syndrome (ACS ...
Shaotao Zhang, Jiannan Dai, Haibo Jia, Sining Hu, Hongwei Du, Ning Li, Yongpeng Zou, Yanan Zou, Shenhong Jing, Yan Wang, Rong Sun, Bo Yu   +11 more
doaj   +1 more source

Neonatal hypoxia-ischemia in rat elicits a region-specific neurotrophic response in SVZ microglia

Journal of Neuroinflammation, 2020
Background Recent findings describe microglia as modulators of neurogenesis in the subventricular zone (SVZ). SVZ microglia in the adult rat are thought to adopt a neurotrophic phenotype after ischemic stroke.
Urs Fisch, Catherine Brégère, Florian Geier, Laurie Chicha, Raphael Guzman   +4 more
doaj   +1 more source

Predicting Diagnostic Gene Biomarkers Associated With Immune Checkpoints, N6-Methyladenosine, and Ferroptosis in Patients With Acute Myocardial Infarction

Frontiers in Cardiovascular Medicine, 2022
This study aimed to determine early diagnosis genes of acute myocardial infarction (AMI) and then validate their association with ferroptosis, immune checkpoints, and N6-methyladenosine (m6A), which may provide a potential method for the early diagnosis ...
Xiao Tong, Xiao Tong, Xinyi Zhao, Xinyi Zhao, Xuan Dang, Xuan Dang, Yan Kou, Yan Kou, Junjie Kou, Junjie Kou   +9 more
doaj   +1 more source