Pharmacologic modulation of experimental postischemic hepatic function [PDF]
, 1989 The present study, evaluated and compared the effects of SRI 63-441, a potent platelet activating factor antagonist, superoxide dismutase (SOD), an oxygen free radical scavenger, and ibuprofen, a cyclooxygenase inhibitor on hepatic function after 90 ...
Makowka, L +5 more
core +2 more sources
Unsupervised Non Linear Dimensionality Reduction Machine Learning methods applied to Multiparametric MRI in cerebral ischemia: Preliminary Results [PDF]
Proceedings of the SPIE, Volume 9034, id. 90342O 9 pp. (2014), 2016 The evaluation and treatment of acute cerebral ischemia requires a technique that can determine the total area of tissue at risk for infarction using diagnostic magnetic resonance imaging (MRI) sequences. Typical MRI data sets consist of T1- and T2-weighted imaging (T1WI, T2WI) along with advanced MRI parameters of diffusion-weighted imaging (DWI) and ...
arxiv +1 more source
Damage to Mitochondrial Complex I During Cardiac Ischemia Reperfusion Injury is Reduced Indirectly by Anti-anginal Drug Ranolazine [PDF]
, 2012 Ranolazine, an anti-anginal drug, is a late Na+ channel current blocker that is also believed to attenuate fatty acid oxidation and mitochondrial respiratory complex I activity, especially during ischemia.
Antholine, William E. +4 more
core +2 more sources
Acta Neuropathologica Communications, 2018 The central nervous system (CNS) contains several types of immune cells located in specific anatomic compartments. Macrophages reside at the CNS borders surrounding the brain vessels, in leptomeningeal spaces and the choroid plexus, where they interact ...
Jordi Pedragosa +13 more
doaj +1 more source
Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia [PDF]
European Journal of Pharmacology 453(2-3): 189-195 (2002), 2007 Cyclooxygenase-2 is involved in the inflammatory component of the ischemic cascade, playing an important role in the delayed progression of the brain damage. The present study evaluated the pharmacological effects of the selective cyclooxygenase-2 inhibitor nimesulide on delayed neuronal death of hippocampal CA1 neurons following transient global ...
arxiv
Physiologically-Based Pharmacokinetic Modeling of Blood Clearance of Liver Fluorescent Markers for the Assessment of the Degree of Hepatic Ischemia-Reperfusion Injury [PDF]
arXiv, 2023 During liver transplantation, ischemia-reperfusion injury (IRI) is inevitable and decreases the overall success of the surgery. While guidelines exist, there is no reliable way to quantitatively assess the degree of IRI present in the liver. Our recent study has shown a correlation between the bile-to-plasma ratio of FDA-approved sodium fluorescein (SF)
arxiv
Bioresorbable Scaffolds: Contemporary Status and Future Directions
Frontiers in Cardiovascular Medicine, 2020 Percutaneous coronary intervention, which is safe, effective, and timely, has become an important treatment for coronary artery diseases and has been widely used in clinical practice. However, there are still some problems that urgently need to be solved.
Xiang Peng +12 more
doaj +1 more source
Cyclooxygenase inhibition in ischemic brain injury [PDF]
Current Pharmaceutical Design 2008; 14(14):1401-1418, 2008 Neuroinflammation is one of the key pathological events involved in the progression of brain damage caused by cerebral ischemia. Metabolism of arachidonic acid through cyclooxygenase (COX) enzymes is known to be actively involved in the neuroinflammatory events leading to neuronal death after ischemia.
arxiv
Comparison of Epilepsy Induced by Ischemic Hypoxic Brain Injury and Hypoglycemic Brain Injury using Multilevel Fusion of Data Features [PDF]
Fusion: Practice and Applications Volume 10 , Issue 1 , PP:
100-115, 2023The study aims to investigate the similarities and differences in the brain damage caused by Hypoxia-Ischemia (HI), Hypoglycemia, and Epilepsy. Hypoglycemia poses a significant challenge in improving glycemic regulation for insulin-treated patients, while HI brain disease in neonates is associated with low oxygen levels.
arxiv +1 more source
Intraoperative hyperglycemia augments ischemia reperfusion injury in renal transplantation: a prospective study. [PDF]
, 2011 Background. Diabetes is a risk factor for delayed graft function in kidney transplantation, and hyperglycemia increases ischemia reperfusion injury in animal models. Methods.
Dang, Kim +3 more
core +5 more sources