Results 61 to 70 of about 968,316 (339)

Heat Shock Protein 70 Protects the Heart from Ischemia/Reperfusion Injury through Inhibition of p38 MAPK Signaling. [PDF]

, 2020
BackgroundHeat shock protein 70 (Hsp70) has been shown to exert cardioprotection. Intracellular calcium ([Ca2+]i) overload induced by p38 mitogen-activated protein kinase (p38 MAPK) activation contributes to cardiac ischemia/reperfusion (I/R) injury ...
Chen, Qing-Cai, Ji, Fu-Hai, Liu, Hong, Liu, Hua-Yue, Ma, Jiao, Meng, Xiao-Wen, Peng, Ke, Song, Nan, Song, Shao-Yong, Wang, Hui, Zhang, Juan   +10 more
core   +1 more source

CARDIAC ISCHEMIA

, 2022
Ischemic heart disease, or ischemic heart disease, is a chronic or acute disorder of the blood supply to the myocardium (the layer of muscle in the heart). This is because the heart does not get enough oxygen. This occurs when arterial blood is given to the heart muscle in limited amounts due to coronary artery injury.
openaire   +3 more sources

A DIA‐MS‐based proteomics approach to find potential serum prognostic biomarkers in glioblastoma patients

Molecular Oncology, EarlyView.
A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul, François Guillonneau, Odile Blanchet, Hamza Lasla, Audrey Rousseau, Catherine Guette, Alice Boissard, Cécile Henry, Morgan Dhondt, Pascal Jézéquel, Philippe Menei, Jean‐Michel Lemée   +11 more
wiley   +1 more source

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

FEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li, Yuwei Tang, Wenkang Liu, Fang Fang, Jiepeng Wang, Chaoyi Fang   +5 more
wiley   +1 more source

Combined analysis of single-cell and bulk transcriptome sequencing data identifies critical glycolysis genes in idiopathic pulmonary arterial hypertension

Journal of Translational Medicine
Background Abnormal glycolytic metabolism plays a significant role in pulmonary vascular remodeling in idiopathic pulmonary arterial hypertension (IPAH), yet the specific mechanisms remain unclear.
Xuan Gao, Youli Fan, Guijia Wang, Jiangjiang Xu, Runwei Deng, Jiangwei Song, Binfeng Sun, Yongbing Wang, Zixuan Wu, Ruyi Jia, Jing Huang, Huiyu He, Lei Gao, Yihao Zhang, Na Sun, Bingxiang Wu   +15 more
doaj   +1 more source

Variability of the Heart Rhythm as an Additional Marker for Determining Vegetative Functions in Patients with Chronic Cerebral Ischemia [PDF]

, 2018
Aim. Practical cardiology is in constant search for non-invasive vascular risk markers. Heart rhythm reflects the body\u27s response to various stimuli of the external and internal environment. Heart rate variability (HRV) has a prognostic and diagnostic
Inhula, N. (Nataliia)
core   +2 more sources

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Differential Expression and Bioinformatics Analysis of CircRNA in PDGF-BB-Induced Vascular Smooth Muscle Cells

Frontiers in Genetics, 2020
Atherosclerosis is mediated by various factors and plays an important pathological foundation for cardiovascular and cerebrovascular diseases.
Jiangtian Tian, Jiangtian Tian, Yahong Fu, Yahong Fu, Qi Li, Qi Li, Ying Xu, Ying Xu, Xiangwen Xi, Xiangwen Xi, Yuqi Zheng, Yuqi Zheng, Li Yu, Li Yu, Zhuozhong Wang, Zhuozhong Wang, Bo Yu, Jinwei Tian   +17 more
doaj   +1 more source

Diagnostic Challenge: The Case of a 70‐Year‐Old Man Who Presents With Progressive Vision Loss and Headaches

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 70‐year‐old presents with 6 weeks of progressive bilateral vision loss and headaches. He was also recently treated for presumed sciatica. His exam on admission is notable for poor visual acuity (no light perception), optic nerve atrophy bilaterally with swelling and disc hemorrhage on the left eye and left foot drop.
Malya Sahu, Rohini Samudralwar
wiley   +1 more source

Early markers of angiogenesis and ischemia during bowel conduit neovascularization [PDF]

, 2017
Background Bowel flaps are a good and reliable method to restore the continuity of the aerodigestive tract. Radiated fields, contaminated recipient sites, or depleted recipient vessels may increase the risk for ischemic injury after transfer.
Chen, Hung-chi, Chen, Pei-yu, Ciudad, Pedro, Li, Yun-fen, Lo Torto, Federico, Manrique, Oscar J., Nguyen, Doan-minh, Wong, Alex   +7 more
core   +1 more source