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Remote Ischemic Conditioning: Challenges and Opportunities
Stroke, 2023 Remote ischemic conditioning (RIC) has been investigated as a promising, safe, and well-tolerated nonpharmacological therapy for cardio-cerebrovascular disease over the past 3 decades; variable results have been found when it is used in cerebrovascular versus cardiovascular disease.
Wenbo Zhao +4 more
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Translational challenges of remote ischemic conditioning in ischemic stroke – a systematic review [PDF]
Annals of Clinical and Translational Neurology, 2021 AbstractRemote ischemic conditioning (RIC) has well‐established cardioprotective effects in preclinical studies and promising results in preclinical stroke research. Effective translation from preclinical studies to clinical trials has yet to be accomplished, perhaps because of the use of multiple applications of RIC (e.g., pre‐, per‐, or post ...
Line Fuglsang Hansen +3 more
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Ameliorative potential of conditioning on ischemia-reperfusion injury in diabetes
, 2018 Diabetes is a serious metabolic disease characterized by hyperglycemia. Diabetes also leads to several long-term secondary complications. Cardiovascular disease is an important complication of diabetes and is a major contributor to morbidity and ...
Rehni, Ashish K, Dave, Kunjan R
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Journal of the American College of Cardiology, 2015 In remote ischemic conditioning (RIC), brief, reversible episodes of ischemia with reperfusion in one vascular bed, tissue, or organ confer a global protective phenotype and render remote tissues and organs resistant to ischemia/reperfusion injury. The peripheral stimulus can be chemical, mechanical, or electrical and involves activation of peripheral ...
Heusch, Gerd +4 more
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Remote Ischemic Conditioning and Stroke Recovery
Neurorehabilitation and Neural Repair, 2021 Remote ischemic conditioning (RIC) is a noninvasive procedure whereby several periods of ischemia are induced in a limb. Although there is growing interest in using RIC to improve stroke recovery, preclinical RIC research has focused exclusively on neuroprotection, using male animals and the intraluminal suture stroke model, and delivered RIC at times ...
Matthew W. McDonald +7 more
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Cerebral conditioning: Mechanisms and potential clinical implications
Brain Hemorrhages, 2022 Cerebral conditioning is defined as the mild harmful stimuli applied to the brain before ischemia (preconditioning), during ischemia (perconditioning), immediately, a few hours or days after reperfusion (postconditioning).
Rui Sheng, Jia-Li Chen, Zheng-Hong Qin
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Ischemic Conditioning in Kidney Transplantation
Journal of Cardiovascular Pharmacology and Therapeutics, 2017 Ischemia–reperfusion injury is a composite of the injury sustained during a period of reduced or absent blood flow to a tissue or organ and the additional insult sustained on reperfusion, which limits the amount of tissue that can be salvaged. Ischemia–reperfusion injury is the predominant insult during kidney transplantation, contributing to graft ...
Veighey, K, MacAllister, R
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The application of remote ischemic conditioning in cardiac surgery [version 1; referees: 3 approved]
F1000Research, 2017 Perioperative myocardial ischemia and infarction are the leading causes of morbidity and mortality following anesthesia and surgery. The discovery of endogenous cardioprotective mechanisms has led to testing of new methods to protect the human heart ...
Zeljko J. Bosnjak, Zhi-Dong Ge
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PLoS ONE, 2012 BackgroundRemote ischemic conditioning is gaining interest as potential method to induce resistance against ischemia reperfusion injury in a variety of clinical settings.
Daniel Brevoord +5 more
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Decreased brain K(ATP) channel contributes to exacerbating ischemic brain injury and the failure of neuroprotection by sevoflurane post-conditioning in diabetic rats. [PDF]
PLoS ONE, 2013 Diabetes leads to exacerbating brain injury after ischemic stroke, but the underlying mechanisms and whether therapeutic intervention with anesthetic post-conditioning can induce neuroprotection in this population are not known.
Dongliang Li +4 more
doaj +1 more source