Results 131 to 140 of about 262,486 (214)

Tissue‐Resident Macrophage in Inflammation and Cancer

MedComm, Volume 7, Issue 9, September 2026.
Opposing macrophage functions in inflammation and cancer converge on shared mechanistic nodes, informing cross‐disease therapeutic strategies. ABSTRACT Tissue‐resident macrophages (TRMs) are long‐lived immune cells strategically distributed across organs, where their functional plasticity enables both homeostatic maintenance and pathological ...
Siyuan Huang, Jiangbo Fan, Wenyi Liu, Di Liu, Rui Wang, Yuanyang Wang, Jianhui Sun, Huacai Zhang, Qingli Cai, Zhe Xu, Fang Xu, Jianxin Jiang, Zhen Wang, Ling Zeng   +13 more
wiley   +1 more source

Identificación de nuevos biomarcadores en los síndromes coronarios agudos [PDF]

, 2012
[spa] La aterosclerosis, engrosamiento de la pared arterial, puede progresar gradualmente hasta complicarse con la aparición de un trombo ocasionando una obstrucción brusca de una arteria con obliteración del flujo en el órgano irrigado por dicha arteria.
Cubedo Ràfols, Judit
core  

Applications of Mesenchymal Stromal Cells for Treatment of Diseases

MedComm, Volume 7, Issue 9, September 2026.
This schematic summarizes the major therapeutic mechanisms of MSCs across different disease systems and highlights factors associated with MSCs dysfunction, together with current strategies to enhance MSCs function and therapeutic efficacy. This summary diagram illustrates that MSCs exert therapeutic effects in various diseases through multiple ...
Dongmei Xue, Yongsheng Li, Lei Wu
wiley   +1 more source

Experimental substantiation of an opportunity of the use of vardenafil for pharmacological preconditioning in surgery

Кубанский научный медицинский вестник, 2015
The possibility of vardenafil using for pharmacological preconditioning in surgery is studied. Experiment was carried out on Wistar rats. The influence of vardenafil on the survival of pedicled isolated skin flap and the state of the microvasculature in ...
I. M. Kolesnik, M. V. Pokrovskiy, V. A. Lasarenko   +2 more
doaj  

Pre‐Incision Time Intervals and Outcomes of Free Flap re‐Exploration: A Retrospective Single‐Center Study

Microsurgery, Volume 46, Issue 6, September 2026.
ABSTRACT Background Timely re‐exploration is critical when free flaps show vascular compromise. However, the relative contribution of modifiable pre‐incision delays after surgery registration and opportunities to shorten time to re‐exploration within the recognition‐to‐incision pathway after flap ischaemia recognition remain uncertain. This study aimed
Alexander Fiedler, Nesrin Ibrahim, Maria Füth, Tatjana Katharina Fricke, Sonja Verena Schmidt, Felix Reinkemeier, Flemming Puscz, Yonca Steubing, Marcus Lehnhardt, Christoph Wallner, Marius Drysch   +10 more
wiley   +1 more source

ISCHEMIC PRECONDITIONING AND ITS CARDIOPROTECTIVE EFFECT IN POST-INTERVENTION CARDIAC REHABILITATION PROGRAMMES FOR PATIENTS WITH CORONARY HEART DISEASE

Российский кардиологический журнал, 2012
In patients with coronary heart disease (CHD), ischemic preconditioning facilitates the mechanisms of cardioprotection and metabolic adaptation to non-fatal ischemia, which is particularly important for the individuals with reduced coronary flow reserve.
E. S. Karpova, E. V. Kotelnikova, N. P. Lyamina   +2 more
doaj  

New perspectives on VEGF signalling in Alzheimer's disease

Brain Pathology, Volume 36, Issue 5, September 2026.
Emery et al. bring together findings from recent multi‐omic studies, including single‐cell mRNA analysis of human post‐mortem brain tissue, and proteomic analysis of matched CSF and blood samples in large clinical studies. The authors present evidence of the involvement of altered VEGF signalling in vascular and immune dysfunction and neurodegeneration
Cherelle E. G. Emery, Seth Love, J. Scott Miners   +2 more
wiley   +1 more source

PRECONDITIONING AS PROTECTION AGAINST ISCHEMIC MYOCARDIAL INJURY

Acta Biomedica Scientifica, 2013
The article discusses the phenomenon of metabolic adaptation to ischemia after repeated episodes of transient reduction in myocardial perfusion. It is shown that the phenomenon of ischemic preconditioning is to significantly improve the stability of the ...
M. G. Shurygin, I. A. Shurygina, N. N. Dremina, O. V. Kanya   +3 more
doaj  

Priming with interleukin‐1α and chemical hypoxia modulates the mesenchymal stem cell secretome to dampen microglial inflammation and promote neuroprotection

British Journal of Pharmacology, Volume 183, Issue 17, Page 5355-5371, September 2026.
Abstract Background and Purpose We hypothesised that dual priming of human bone marrow‐derived human mesenchymal stem cells (hBMSCs) with interleukin‐1alpha (IL‐1α) and CoCl2 (a hypoxia mimetic) would modulate their therapeutic efficacy for hypoxic‐ischaemic conditions. Experimental Approach hBMSCs were primed individually or in combination.
Maryam Adenike Salaudeen, Stuart M. Allan, Emmanuel Pinteaux   +2 more
wiley   +1 more source

Therapeutic Potential of Gene‐Modified MSC‐Exos in Insulin Resistance: Mitochondrial Crosstalk and miRNA Regulation

Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.
ABSTRACT Insulin resistance (IR) is the key driver of type 2 diabetes mellitus, metabolic dysfunction‐associated steatotic liver disease, and cardiometabolic disorders. Mesenchymal stem cell‐derived exosomes (MSC‐Exos) as a potent cell‐free alternative can deliver miRNAs, proteins, and mitochondrial regulators to reactivate the IRS1/PI3K/Akt/GLUT4 axis.
Qinghua Jia, Bing Li, Yuan Xing, Yuanyuan Zhang, Baodong Gao, Xiangying Li, Xiaoqin Ha   +6 more
wiley   +1 more source