Results 111 to 120 of about 25,118 (249)

Sorafenib Restores Pentose Phosphate Pathway‐Related Redox Homeostasis via the c‐Raf/HSP90/G6PD Axis in Hepatic Ischemia‐Reperfusion Injury

MedComm, Volume 7, Issue 7, July 2026.
Proposed mechanism of middle‐dose sorafenib modulates redox homeostasis via c‐Raf/HSP90/G6PD axis to attenuate hepatic IRI. This study demonstrates that middle‐dose sorafenib mitigates hepatic IRI through the c‐Raf/HSP90/G6PD axis to enhance pentose phosphate pathway‐mediated antioxidant defense and redox homeostasis, thereby alleviating inflammatory ...
Fengqiang Gao, Libin Dong, Yawen Tan, Zhen Zhang, Shengjun Xu, Zijian Lou, Yichao Wu, Siyu Chen, Li Zhuang, Zhengxing Lian, Shusen Zheng, Nasha Qiu, Kai Wang, Xiao Xu   +13 more
wiley   +1 more source

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang   +4 more
wiley   +1 more source

Aging-associated Alteration in the Cardiac MIF-AMPK Cascade in Response to Ischemic Stress

, 2008
An important role for a macrophage migration inhibitory factor (MIF)-AMP-activated protein kinase (AMPK) signaling pathway in ameliorating myocardial damage following ischemia/reperfusion has been described. An aging-associated reduction in AMPK activity
Lin Leng, Richard Bucala, Erin Lane, Heng Ma, Jingying Wang, Jun Ren, Wenkui Wang, Ji Li   +7 more
core  

MicroRNAs Induced During Ischemic Preconditioning

, 2010
Background and Purpose— MicroRNAs (miRNA) are single-stranded short RNA molecules that regulate gene expression by either degradation or translational repression of mRNA.
Kon Chu, Jae-Kyu Roh, Lee, Soon-Tae, Sang Kun Lee, Hye-Jin Yoon, Manho Kim, Ki-Ho Park, Jung, Keun-Hwa, Bae, Eun-Kee, Roh, Jae-Kyu, Kim, Manho, Daejong Jeon, Soon-Tae Lee, Keun-Hwa Jung, Kyoung-Mook Kang, Yoon, Hye-Jin, Park, Ki-Ho, Lee, Sang Kun, Jeon, Daejong, Eun-Kee Bae, Chu, Kon   +20 more
core   +1 more source

Endothelial Netrin‐4 regulates oligodendrocyte precursor cell proliferation and differentiation via ET‐1 signaling in preterm white matter injury

Brain Pathology, Volume 36, Issue 4, July 2026.
Our findings show early increased Netrin‐4 in mice with PWMI boosts angiogenesis and OPCs proliferation. Later, high levels hinder OPCs differentiation into mature cells, impairing myelination. It may act by stimulating ET‐1 secretion. Abstract Perinatal hypoxia–ischemia is a leading cause of preterm white matter injury (PWMI), yet mechanisms ...
Fuxing Dong, Weixing Yan, Qiqi Meng, Xueli Song, Bing Cheng, Yaping Liu, Yanan Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source

Biomarkers for Ischemic Preconditioning: Finding the Responders

, 2014
Ischemic preconditioning is emerging as an innovative and novel cytoprotective strategy to counter ischemic vascular disease. At the root of the preconditioning response is the upregulation of endogenous defense systems to achieve ischemic tolerance ...
Sacco, RL, Ralph L Sacco, Dave, KR, Kunjan R Dave, Miguel A Perez-Pinzon, Sebastian Koch, Koch, S, Della-Morte, David, David Della-Morte, Sacco, Ralph L, Perez-Pinzon, Miguel A, DELLA MORTE, DAVID, Koch, Sebastian, Perez Pinzon, MA, Dave, Kunjan R   +14 more
core   +1 more source

Remote ischemic preconditioning and its role in the prevention of new onset atrial fibrillation post‐cardiac surgery. A meta‐analysis of randomized control trials

Journal of Arrhythmia, 2019
Background The denouement of remote ischemic preconditioning on new onset atrial fibrillation (NOAF) post‐cardiac surgery is not well‐established.
Ashish Kumar, Harpreet Singh, Mariam Shariff   +2 more
doaj   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, Volume 13, Issue 33, 15 June 2026.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Postconditioning protects against endothelial ischemia-reperfusion injury in the human forearm

, 2006
Background: Hypoxic cell death follows interruption of blood supply to tissues. Although successful restoration of blood flow is mandatory for salvage of ischemic tissues, reperfusion can paradoxically place tissues at risk of further injury.
MacAllister, R.J., Loukogeorgakis, S.P., Panagiotido, A.T., Yellon, D.M., Deanfield, J.E.   +4 more
core  

Acute hyperglycemia abolishes ischemic preconditioning in vivo

, 1998
Ischemic preconditioning provides a powerful means to reduce myocardial infarct size in vivo and has been proposed to limit the extent of myocardial infarction in patients.
Paul S. Pagel, Judy R. Kersten, Todd J. Schmeling, Karl G. Orth, David C. Warltier   +4 more
core   +1 more source